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Clear cell renal cell carcinoma (ccRCC) is the most prevalent histological subtype of renal cancer, with both incidence and mortality rates on the rise in recent years. This underscores the urgent need for precise diagnostic …
Read PDFPancreatic neuroendocrine tumors (PNETs) represent a biologically heterogeneous group of neoplasms shaped by both intrinsic genomic alterations and dynamic interactions with the tumor microenvironment (TME). Conventional analytical approaches offered limited insight into these complex mechanisms. …
Read PDF<h4>Background</h4>Breast cancer brain metastasis (BCBM) is a lethal complication of advanced disease, facilitated by a specialized neuro-immune microenvironment, whereas its molecular regulators and spatial dynamics remain poorly understood. This study aimed to resolve cellular heterogeneity …
Read PDFTriple-negative breast cancer is defined by the absence of druggable receptor targets and by a biologically dynamic phenotype that renders static, single-timepoint biomarker strategies fundamentally inadequate. Current predictive markers, including PD-L1 expression, tumor mutational burden, …
Read PDFResistance to systemic therapy remains the defining challenge in the management of gastric cancer (GC) and esophageal adenocarcinoma (EAC). While genomic drivers of resistance are well characterized, traditional bulk profiling has failed to capture the …
Read PDFNeuroblastoma is the most common extracranial solid tumor in children, presenting significant challenges in diagnosis and treatment due to its highly heterogeneous clinical manifestations and complex genetic background. In recent years, advances in transcriptomics have …
Read PDFMental disorders refer to abnormal states that affect an individual's thinking, emotion, behavior, and perception, and are generally associated with dysregulation of brain function. They exhibit genetic heterogeneity as well as multi-level structural and functional …
Read PDFSynthesizing recent literature from 2025 to 2026, this mini-review critically evaluates the methodological evolution of artificial intelligence (AI) in hepatocellular carcinoma (HCC) from static pattern recognition to mechanism-driven spatial and imaging diagnostics. We expose a …
Read PDFCommensal bacteria play a crucial role in modulating human immune responses in the intestine. Under homeostatic conditions, the gut microbiota is tightly regulated by interactions with the mucosal immune system. However, colorectal cancer (CRC) is …
Read PDFSpatial transcriptomics enables in situ gene expression profiling, yet precise spatial domain identification and marker gene detection remain challenging. We present HarveST, a heterogeneous graph-based framework that integrates spatial, transcriptomic, and gene-gene interaction data through …
Read PDFLeveraging advanced materials is an increasingly important direction in immune engineering, which aims to reprogram immune responses to treat disease. Once implanted, biomaterials rapidly become sites where immune cells assemble, interact, and collectively shape material …
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Read PDFOsteosarcoma (OS), the most frequent primary malignant bone tumor in children and adolescents, is characterized by substantial inter- and intra-tumoral heterogeneity and an immunosuppressive tumor microenvironment (TME), constraining the efficacy of both standard chemotherapy and …
Read PDFChina has rich bamboo resources, with Moso bamboo (<i>Phyllostachys edulis</i>) being the most economically important species. Bamboo shoot bud development directly determines the eating quality of the shoots and the properties of bamboo materials; however, …
Read PDFAlthough DNA has built the framework for molecular insights from museum collections, the utility of archival RNA remains largely unexplored. Likely a consequence of the known instability of RNA relative to DNA, this has effectively …
Read PDF<h4>Motivation</h4>Characterizing the neuronal connectomes provides route to understand the basis of neural circuit in brains, one of the central missions in neuroscience, but the mapped connectivity is absent of molecular information, obscuring the understanding on …
Read PDFWith emerging single-cell transcriptomics data, deep learning approaches have enabled the diagnosis of neurodegenerative disorders such as Parkinson's disease(PD). Based on whole-blood RNA sequencing data, the graph neural network has predicted Parkinson's disease(PD) progression trajectories …
Read PDFSubcellular RNA localization, including nuclear retention and apical-basal compartmentalization in polarized epithelia plays a central role in post-transcriptional regulation. However, methods for high-throughput mapping of mRNA localization within intact tissue sections remain limited. Here, we …
Read PDFImmune checkpoint blockade has transformed cancer therapy, achieving lasting responses in some patients, yet most still encounter primary or acquired resistance. Recent evidence demonstrates that this resistance is driven not only by intrinsic cellular features …
Read PDFNucleotide metabolism significantly influences tumor cell proliferation, yet its specific profile in pancreatic cancer remains inadequately understood. This study was aimed at characterizing the nucleotide metabolic profile in pancreatic cancer and assessing the contribution of …
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