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Skin aging is a complex, multifactorial process driven by intrinsic biological mechanisms and environmental exposures, resulting in progressive functional and structural decline. Chronological age does not adequately capture this variability, highlighting the need for molecular …
Read PDF<h4>Introduction</h4>Long COVID affects hundreds of millions of individuals worldwide, yet its underlying biological mechanisms remain incompletely understood, and the absence of validated biomarkers continues to limit diagnosis and clinical management. Most biomarker studies have focused …
Read PDF<h4>Background</h4>Lung adenocarcinoma (LUAD) exhibits marked heterogeneity. Organelle stress-adaptive programs that tumor cells develop under hypoxia, nutrient limitation, and proteostasis pressure may drive functional reprogramming of tumor biology, remodel the immune microenvironment, and ultimately influence the …
Read PDF<h4>Background</h4>POU5F1 (OCT4), a core regulator of pluripotency, plays an important role in tumor stemness and immune microenvironment remodeling, yet its systematic function and mechanisms in lung adenocarcinoma (LUAD) remain incompletely elucidated.<h4>Methods</h4>This study integrated genetic causality …
Read PDF<h4>Objective</h4>This study aims to explore how the tumour microenvironment influences the aggressiveness, malignancy, and recurrence of ameloblastoma. By employing a spatial omics approach, we will examine the characteristics of the invasive front of ameloblastoma.<h4>Methods</h4>We systematically …
Read PDFSpatial transcriptomics (ST) enables genome-wide gene expression profiling while preserving tissue architecture, bridging the gap between bulk, single-cell, and histological analyses. Originating in 2016 and rapidly evolving since, ST has transformed infectious disease research by …
Read PDFBACKGROUND: Spatial and temporal intratumoral heterogeneity (ITH) remains a major challenge in the diagnosis, prognosis, and treatment of breast cancer. Recent advances in single-cell and spatial omics technologies have enabled unprecedented resolution of subclonal architectures, …
Read PDFThe traditional paradigm of linking single genes to individual phenotypes is being replaced by a systems-level framework to understand the complexity of the tumor microenvironment. In this context, in silico knockout has emerged as a …
Read PDFCelcomen leverages a mathematical causality framework to disentangle intra- and inter-cellular gene regulation programs in spatial transcriptomics data through a generative graph neural network. It is a first step towards perturbation models of Virtual Tissues …
Read PDFThe lung tumour microenvironment is a complex and evolving ecosystem in which immune, stromal and malignant cells interact across both space and time. Spatial organisation determines whether immune cells can access and induce immune responses …
Read PDFThe life sciences are currently undergoing a serious transition from the reductive biochemical analysis of dissociated tissues to non-destructive "spatial forensics". In addition to discovering new molecules, we are moving towards finding out their precise …
Read PDFSpatial transcriptomics technologies profile gene expression across tissue sections while retaining spatial information, yet most platforms capture signals from multiple cells per measurement location, requiring computational methods to determine the underlying cellular composition. Current deconvolution …
Read PDFBrain metastases occur in up to 40% of patients with stage IV breast cancer, and the cerebellum is a common site for metastases in HER2-positive breast cancer. We developed a syngeneic, immunocompetent mouse model of …
Read PDFCereals form complex, highly ordered inflorescences composed of grain-producing florets that form within spikelets. Wheat spikelets are arranged in alternating rows along a central rachis, in a pattern determined during early development. While several genes …
Read PDFLinking spatial transcriptomic data to clinically relevant phenotypes is essential for advancing spatially informed precision oncology. Here, we present SpaPheno, an interpretable machine learning framework that integrates spatial transcriptomics with clinically annotated bulk RNA-seq to …
Read PDF<b>Background:</b> Microplastics and lead are ubiquitous pollutants in the environment, frequently found in soil, water and food. Although the toxicity of individual exposure to microplastics and lead has been well studied, research on their co-exposure …
Read PDF<h4>Background</h4>Although immune checkpoint blockade (ICB) therapy has improved clinical outcomes for some patients with lung adenocarcinoma (LUAD), only a subset of cases can achieve durable benefits, and primary resistance is often associated with an immune-excluded …
Read PDFColon adenocarcinoma (COAD) exhibits substantial molecular and microenvironmental heterogeneity, limiting the reliability and clinical application of single-omics biomarkers. Post-translational modifications (PTMs) play a pivotal role in connecting genotype to phenotype, yet prognostic models informed by …
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