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<h4>Background</h4>Natural killer (NK) cells are core components of innate antitumor immunity, the dysfunction of NK cells in the tumor microenvironment is a major obstacle to the antitumor efficacy. Runt-related transcription factor 3 (RUNX3) acts as …
Read PDF<h4>Background</h4>Previous studies have integrated genome-wide association studies with expression quantitative trait locus (eQTL) data from bulk tissues to identify stroke susceptibility genes. However, eQTL data exhibit high cell-type specificity, and genetic variants may have distinct …
Read PDF<h4>Background</h4>Developmental dysplasia of the hip (DDH) is a common pediatric orthopedic disorder that predisposes affected children to early-onset osteoarthritis (OA), yet the cellular heterogeneity and fibrotic remodeling of acetabular cartilage are poorly understood.<h4>Methods</h4>We performed single-cell …
Read PDF<h4>Background</h4>Cirrhosis is a severe liver disease characterized by inflammation, fibrosis, and immune dysregulation. This study exploits publicly available single-cell sequencing datasets to decipher disease-relevant specific immune cell subtypes, their gene expression profiles and altered transcription …
Read PDF<h4>Background</h4>Clear cell renal cell carcinoma (ccRCC) is the most common histological subtype of kidney cancer and shows marked heterogeneity in progression, metastasis, and therapeutic response. Sphingolipid metabolism has emerged as an important regulator of tumor …
Read PDF<h4>Background</h4>Endometriosis is a chronic estrogen-dependent inflammatory disease that shares epidemiological and pathological features with endometrial cancer. However, the cellular and genetic mechanisms underlying this association remain unclear.<h4>Aim</h4>To investigate the immunological mechanisms underlying endometriosis and endometrial …
Read PDFLung cancer in smokers (LCIS) and lung cancer in never-smokers (LCINS) are different entities with distinct molecular features. However, their cellular heterogeneity still requires further investigation. Through an integrated analysis of single-cell RNA sequencing and …
Read PDFClustering is commonly used in single-cell RNA sequencing (scRNA-seq) to assess cellular heterogeneity, but standard methods often require user-specified heuristics and rely on post-selective differential expression analyses, which often lead to inflated false discovery rates. …
Read PDFThe 5-year overall survival rate for hepatocellular carcinoma (HCC) patients remains below 20%. Alterations in the extracellular matrix (ECM) are increasingly recognized as central drivers of HCC initiation and progression. This study applied a system …
Read PDFDiabetic foot ulcers (DFU) is severe complications of diabetes mellitus, affecting 15–25% of diabetic patients and imposing substantial healthcare burdens. Lactylation has emerged as a critical regulator in inflammation and wound healing processes. However, the …
Read PDF<h4>Background</h4>Low-density lipoprotein (LDL) is a critical regulator of lipid metabolism and has been implicated in the development and progression of various malignancies. However, its specific roles and mechanisms in the ovarian cancer tumor microenvironment (TME) …
Read PDFSkeletal stem cells (SSCs) are well characterized in humans and mice, providing valuable insights into bone development and regeneration. However, their identification in poultry, particularly in chicken embryos, remains limited. In the present study, we …
Read PDFIschemic stroke is a cerebrovascular disease that can cause long-term neurological impairment, dementia, or death. It is the third most common cause of disability and the second leading cause of death worldwide. The aim of …
Read PDFBenign prostatic hyperplasia (BPH) is an age-related prostate disorder with incompletely defined mechanisms. We integrated laser capture microdissection RNA sequencing, public single-cell RNA sequencing, public spatial transcriptomics, human tissue validation, mouse-model analyses, and <i>in vitro</i> …
Read PDF<h4>Background</h4>Microsatellite stable (MSS) gastric cancer (GC) responds poorly to immunotherapy and exhibits heterogeneous outcomes. Histone lactylation plays a critical role in cancer progression. However, the prognostic and therapeutic potential of a lactylation-related gene signature (LRGS) …
Read PDFPURPOSE: Dysregulated cholesterol metabolism has emerged as a crucial driver of hepatocellular carcinoma (HCC) progression and immunotherapy resistance. This study aimed to delineate the single-cell landscape of cholesterol metabolism in HCC and identify key molecular …
Read PDF<h4>Background</h4>Type 1 diabetes (T1DM) is a T cell-mediated autoimmune disease. The sphingosine-1-phosphate (S1P) signaling pathway regulates lymphocyte trafficking, but its status in T1DM remains poorly characterized. This study investigated S1P and sphingosine-1-phosphate receptor 1(S1PR1) alterations …
Read PDFCell-cell interactions influence gene expression in the tumor microenvironment, yet despite advances in spatial transcriptomics that enable in situ expression profiling, current computational tools remain limited in quantitatively resolving single-cell and multicellular interaction effects across …
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