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<h4>Background</h4>Silicosis is a work-related condition resulting from breathing in crystalline silica particles, marked by persistent inflammation and abnormal healing mechanisms in the lungs. Our previous studies demonstrated that inhibition of Cxcr4 with Plerixafor (AMD3100) markedly …
Read PDFRecent advances in single-cell transcriptomics and CRISPR-based genome editing have enabled large-scale perturbation experiments with genome-wide expression readouts. Single-cell CRISPR screens offer the opportunity to move beyond correlation and estimate causal effects of genetic perturbations …
Read PDFChronic obstructive pulmonary disease (COPD) is a common and complex heterogeneous chronic inflammatory airway disorder characterized by multifactorial pathogenesis and limited therapeutic options. It remains one of the leading causes of morbidity and mortality worldwide, …
Read PDF<b>Background/Objectives:</b> Cardiac embryonic development is a highly coordinated and dynamic process governed by precise spatiotemporal gene regulation. Increasing evidence indicates that cellular heterogeneity and lineage specification during heart development are tightly controlled by complex gene …
Read PDFEdible coatings (ECs) derived from natural biopolymers represent an effective preservation strategy for fruits and vegetables and a promising postharvest approach aligned with the increasing demand for sustainable agricultural practices. These Generally Recognized As Safe …
Read PDFThe tumor microenvironment (TME) is crucial for tumor formation and progression, but its specific impact on NF2-related tumors has not been well described. The aim of this study was to analyze the differences in the …
Read PDFSpatial omics technologies enable high-resolution mapping of transcriptomic, proteomic, and metabolic profiles within intact tissues, revealing how immune, stromal, and parenchymal cells interact in situ during inflammation. Chronic inflammation in skeletal muscle and the central …
Read PDF<h4>Purpose</h4>Due to the structural complexity of the human cornea as well as the characteristic histopathological changes occurring in keratoconus (KTCN) cornea, there is a need to identify the associated cellular and molecular layer-specific alterations in …
Read PDFChronic liver disease (CLD) represents a major global public health challenge, necessitating a systematic understanding of its complex immunopathological mechanisms. This review comprehensively summarizes the groundbreaking applications of cutting-edge technologies-including single-cell sequencing, spatial transcriptomics, and …
Read PDFAdvances in transcriptomic technologies have progressively transformed the questions we can ask and answer about muscle stem cells (MuSCs) during aging. Early microarray and bulk RNA sequencing studies established foundational population-level signatures of aged MuSCs, …
Read PDFBreast cancer is a heterogeneous disease composed of distinct molecular subtypes that influence prognosis and treatment response, with subtype discordance between primary and metastatic tumors contributing to therapeutic failure. Using GeoMx spatial transcriptomics, we profiled …
Read PDFBACKGROUND: Spatial transcriptomics has rapidly advanced the study of tissue architecture by integrating gene expression profiles, spatial coordinates, and high-resolution histology images. However, accurately identifying spatial domains with coherent transcriptomic and morphological patterns remains challenging. …
Read PDFGenome-scale gene expression analysis has become a standard approach for discovering biomarkers and understanding molecular mechanisms. Recent advances in omics technologies now enable investigations beyond conventional case-control comparison and standard gene-centric differential expression (DE) analyses. …
Read PDFTemporomandibular joint osteoarthritis (TMJ-OA), the most common degenerative disease of the TMJ, is influenced by various adaptive, inflammatory, and mechanical stressors. In this study, we describe molecular alterations of the synovium of the articular disk …
Read PDFDiabetic nephropathy (DN) pathogenesis remains elusive due to the lack of comprehensive spatial molecular characterization related to tissue pathological signatures. Here, we construct the spatial single-cell atlas of human DN kidneys using clinical formalin-fixed paraffin-embedded …
Read PDFColon cancer is one of the most prevalent malignant tumors. Accurate evaluation of patient prognosis and optimization of treatment strategies continue to be major research focuses in colon cancer. Based on The Cancer Genome Atlas …
Read PDF<h4>Background</h4>Graph Convolutional Networks (GCNs) are widely applied for spatial domain identification in spatial transcriptomics (ST), where node representations are learned by aggregating information from neighboring spots. However, most ST workflows construct spatial graphs by assigning …
Read PDFGastrointestinal (GI) cancers remain a leading cause of cancer-related morbidity and mortality worldwide, largely due to their molecular heterogeneity, complex tumor microenvironment (TME), and variable treatment responses. In recent years, the emergence of spatially resolved …
Read PDFAdenomyosis is a common gynecological condition characterized by ectopic endometrial-like tissue deep within the myometrium, causing debilitating symptoms. Treatment options are limited to hormones that primarily focus on symptom management only or invasive hysterectomy. Despite …
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