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Nonfunctioning pituitary adenomas (NFPAs) are common intracranial tumors that, despite being histologically benign, can exhibit invasive growth, as well as postoperative tumor progression. Surgical resection is the primary treatment of choice; however, residual tumor tissue …
Read PDFThe impact that single-cell and spatial genomic technologies have had on the scientific community since their advent has been widespread and profound. The field of spinal cord injury (SCI) is one such area that has …
Read PDFThe thymus is the primary site for T cell maturation. While transcriptional profiling of human thymi has been reported, a high-resolution spatial atlas is needed. Here we use Stereo-seq spatial transcriptomics to generate a spatial …
Read PDFIntrahepatic cholangiocarcinoma (ICC) is an aggressive liver malignancy with a rising global incidence and limited therapeutic options. Vascular invasion (VI) is a hallmark of advanced disease, correlating with early recurrence and dismal prognosis, yet its …
Read PDFThe immunoregulatory architecture of human oral tissues remains poorly defined. We present an integrated single-cell and spatial proteotranscriptomic atlas profiling >250,000 single-cell transcriptomes and >4 million spatially resolved cells across 13 niches. Using our AI-enabled …
Read PDFPlasma transcriptomic profiling has emerged as a promising non-invasive strategy for cancer biomarker discovery, offering a dynamic change in gene expression profiles associated with carcinogenesis. Plasma-based transcriptomic profiling offers a less-invasive alternative for detecting cancer …
Read PDFRetinal ischemia–reperfusion (I/R) injury is a key pathological process in retinal-associated diseases such as glaucoma. However, the spatiotemporal dynamics and cell interactions during this injury are not fully understood. This study integrated single-cell RNA sequencing …
Read PDF<h4>Background</h4>Gliomas exhibit substantial intratumoral heterogeneity, which limits prognostic precision and therapeutic efficacy. Selenoproteins are key regulators of redox homeostasis, but their role in glioma progression remains insufficiently defined. This study aimed to characterize glioma cells …
Read PDFDiffuse large B-cell Lymphoma (DLBCL) is the most prevalent subtype of non-Hodgkin's lymphoma for which current therapeutic strategies remain insufficient, in part owing to heterogeneity in tumor biology and the immune microenvironment. The diffuse nature …
Read PDFDystrophinopathies are caused by pathogenic variants in the DMD gene, resulting in partial (Becker) or complete loss (Duchenne) of dystrophin. Becker (BMD) and Duchenne muscular dystrophy (DMD) are characterized by progressive muscle wasting, fatty replacement, …
Read PDFPancreatic ductal adenocarcinoma (PDAC) is the most complex and aggressive disease with the worst rates of unresectable or metastatic disease at diagnosis, resistance to systemic therapy, and case fatality rate (CFR) among leading cancers. In …
Read PDF<b>Background/Objectives</b>: Environmental conditions in natural and cultivation-managed habitats strongly influence plant physiology and medicinal quality. However, the molecular mechanisms underlying metabolic differentiation in <i>Anoectochilus roxburghii</i> remain poorly understood. This study aimed to elucidate the metabolic …
Read PDFDamage to long myelinated axons of white matter tracts is a hallmark pathology resulting from traumatic brain injury (TBI) forces and secondary injury processes. 4-aminopyridine (4-AP) is an FDA-approved Kv1 potassium channel inhibitor designed to …
Read PDF<h4>Background</h4>Allergic rhinitis (AR) is a common chronic nasal mucosal inflammatory disorder driven by type 2 immunity, but the spatial stromal-immune cell interactions underlying its pathogenesis remain unclear.<h4>Methods</h4>We used 10x Genomics Xenium <i>In Situ</i> spatial transcriptomics …
Read PDFGastric cancer (GC) remains a major global health burden, with its unfavorable prognosis primarily driven by extensive tumor heterogeneity. Traditional bulk omics, while informative, are inherently limited by the averaging effect of diverse cell populations …
Read PDFWhite adipose tissue (WAT) is a remarkably plastic organ integrating metabolic, endocrine and immune functions. In humans, perturbations in adipocyte turnover, size regulation and cellular heterogeneity underpin the transition from metabolic health to obesity-related disease. …
Read PDFMacrophages are central players of inflammation, lipid metabolism, and remodeling in atherosclerotic plaques. Historically simplified into "M1" and "M2" polarization states, their biology has been fundamentally redefined by single-cell and spatial transcriptomic technologies. Over the …
Read PDF<b>Background:</b><i>Rhodopseudomonas palustris</i> is a metabolically versatile bacterium with significant biotechnological potential, including the ability to catabolize lignin and its heterogeneous breakdown products. Understanding the molecular determinants of growth on lignin-derived compounds is essential for advancing …
Read PDFSpatial transcriptomics (ST) technologies enable the profiling of gene expression while preserving spatial context, offering unprecedented insights into tissue organization. However, traditional spatial domain identification methods primarily rely on gene expression matrices and spatial coordinates …
Read PDFThe spatial transcriptomics technique provides an unprecedented perspective for analyzing the distribution patterns of cells within tissues and their functional tissue structures. To enhance the accuracy and robustness of spatial domain identification, we propose Joint …
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