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<b>Background/Objectives</b>: MSS-CRC comprises a heterogeneous group of tumors generally considered "immune cold" due to limited neoantigen generation and T-cell exclusion or inactivation. Current evidence indicates that the composition of T and B immune cells within …
Read PDFThe body's circadian rhythm is coordinated by core clock proteins [period (PER), cryptochrome circadian regulator (CRY), circadian locomotor output cycles kaput (CLOCK), and basic helix-loop-helix ARNT-like protein 1 (BMAL1)] that function in both the central …
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Read PDFDiscovery of phenotype-associated subpopulations is critical for targeted therapies and prognostic biomarker discovery, which requires multi-scale gene expression. Deep learning advancements have enabled cost-effective genetic alteration inference from whole-slide images (WSIs), but most methods operate …
Read PDFUnderstanding tissue complexity requires spatially resolved multi-omics data at single-cell resolution. Here, we present a workflow integrating high-resolution matrix-assisted laser desorption ionization mass spectrometry imaging (MALDI-MSI) with Xenium spatial transcriptomics (SPT) on a single tissue …
Read PDF<h4>Background</h4>Chronic lung allograft dysfunction (CLAD) significantly limits long-term survival of lung transplant recipients, with viral infections acting as critical contributors to its pathogenesis. The mechanisms linking viral infections to CLAD-associated airway fibrosis remain incompletely understood. …
Read PDFThe neocortex, a layered structure unique to mammals, supports higher-order functions, including perception, learning, and decision-making. While its laminar architecture is broadly conserved, the cell type-specific organization of the cortical column has not been compared …
Read PDFIntraoperative frozen section pathological diagnosis of lung adenocarcinoma serves as the gold standard for determining the extent of surgical resection. Due to the dual constraints of intraoperative time limitations and the challenge of manually assessing …
Read PDFBACKGROUND: OSR2 plays a key role in various physiological processes and cancer development. Although interest in OSR2’s role in cancer is increasing, its mechanisms and clinical importance are not fully understood. This study thoroughly examines …
Read PDF<b>Background:</b> Cognitive and psychiatric disorders are caused by a complex interplay between genetic predisposition, environmental exposures, and dynamic molecular regulation in the brain. Animal models provide a controlled environment for examining these mechanisms, and advances …
Read PDFIntermicrobial and host-microbial interactions are critical for the functioning of the gut microbiome, but few tools are available to measure these interactions in situ. Here we report a method for broad spatial sampling of microbiome-host …
Read PDFRotator cuff tear (RCT) is a prevalent age-related condition whose underlying mechanisms remain poorly understood. This study employed spatial transcriptomics and multiplex immunofluorescence (mIF) to investigate gene expression and spatial heterogeneity in rotator cuff tissues …
Read PDFThe rise of single-cell transcriptomics and comprehensive reference atlases promised a unifying molecular framework to classify cell identity. Yet transcriptomic identities are often interpreted outside the environmental contexts in which they arise. Here, we analyzed …
Read PDF<h4>Introduction</h4>Hereditary α-tryptasemia (HαT), defined by increased <i>TPSAB1</i> copy number and elevated basal serum tryptase, is associated with mast cell (MC)-mediated symptoms. However, its role in gastrointestinal disease remains unclear. Because intestinal MCs express the non-IgE-dependent …
Read PDFSpatial transcriptomics (ST) measures gene expression while preserving spatial context within tissues. One of the key tasks in ST analysis is spatial domain detection, which remains challenging due to the complex structure of ST data …
Read PDFColorectal cancer (CRC) remains a significant global health challenge, ranking among the leading causes of cancer-related morbidity and mortality. Accumulating evidence indicates that disease progression and therapeutic resistance in CRC are not solely tumor cells …
Read PDF<h4>Background</h4>Congenital heart disease (CHD) affects approximately 1% of live births worldwide and remains the leading cause of infant mortality from congenital anomalies. Despite advances in diagnosis and therapeutics, the molecular mechanisms underlying CHD pathogenesis remain …
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