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<h4>Background/objectives</h4>Melanoma is one of the deadliest types of skin cancer due to its ability to metastasize if not treated early. While targeted- and immune- therapies have significantly improved melanoma treatment outcomes, acquired drug resistance even …
Read PDFThe management of inflammatory bowel disease (IBD) is challenged by significant patient diversity and a lack of effective profiling tools. This review evaluates the potential of archived formalin-fixed, paraffin-embedded (FFPE) gut biopsies as a resource …
Read PDFA Disintegrin And Metalloproteinase 9 (ADAM9) is a cell-surface protease that can shed the ectodomain of membrane protein substrates. Dysregulated ADAM9 activity has been implicated in several diseases, such as solid tumors, autoimmunity, inflammatory diseases, …
Read PDFThis perspective article examines the integration of traditional phytotherapy into precision medicine for cardiovascular remodeling associated with cardiometabolic syndrome (CMS). Herbal medicine, with its intrinsic multi-target action, aligns well with the complex network pathology of …
Read PDFThe molecular correlates of Alzheimer's disease (AD) are increasingly being defined by multi-omics. However, findings from different data types are often difficult to reconcile. Here, we apply a data-driven multi-omics framework integrating seven omics layers …
Read PDFLimited proteomic evidence makes it unclear to what extent alternative splicing (AS) isoforms are translated and functionally relevant in eukaryotes. Here, we present a comprehensive proteomic analysis in plants using large-scale data mining, extensive fractionation …
Read PDFThe National Cancer Institute's Clinical Proteomic Tumor Analysis Consortium (CPTAC) recently generated harmonized genomic, transcriptomic, proteomic, and clinical data for over 1,000 tumors across 10 cohorts to facilitate pan-cancer discovery research. However, protein expression comparison …
Read PDFBACKGROUND: Proteins represent the dynamic downstream products of genes, and have the potential to substantially increase understanding of the complexities of cancer biology. Undifferentiated pleomorphic sarcoma (UPS) is a rare disease, the proteomic landscape of …
Read PDF<h4>Background</h4>The molecular determinants for lung graft-<i>versus</i>-host disease-associated bronchiolitis obliterans syndrome (BOS) are poorly understood, and biomarkers in children following haematopoietic stem cell transplant do not exist. To address this gap, we analysed plasma samples from …
Read PDFTherapy resistance is the leading cause of cancer-related deaths. Polyploid cancer cells mediate resistance through adaptive cell states transitions that promote survival and tumor recurrence. Here, we investigate metabolic differences between cisplatin-surviving polyploid cells and …
Read PDFHuoshou black pig (HS) is a well-known indigenous Chinese breed distinguished by superior meat quality compared to Western breeds. To investigate the molecular mechanisms underlying these differences, we performed Data-Independent Acquisition(DIA) proteomic analysis on the …
Read PDF<h4>Introduction</h4>The effects of aerobic physical activity on proteolysis-related markers of cardiovascular, kidney, and endothelial dysfunction, such as asymmetric dimethylarginine (ADMA) and symmetric dimethylarginine (SDMA), have not been well studied. Our goal was to investigate the …
Read PDF<h4>Background</h4>Glutamate decarboxylase-like 1 (GADL1) decarboxylates aspartic acid to β-alanine in several mammalian tissues, particularly in the brain and skeletal muscle. β-alanine is a precursor to the antioxidant and osmoregulatory dipeptide carnosine (β-alanyl-l-histidine), as well as …
Read PDFObjective. Myelofibrosis (MF) represents a hallmark of the advanced stage of myeloproliferative neoplasms (MPNs), and anemia serves as an independent factor for poor prognosis. Our study aimed to explore the gene and protein profile in …
Read PDF<h4>Background</h4>Multi-omics technologies have increasingly been applied to systemic autoimmune rheumatic diseases (SARDs), yet the global research landscape and thematic evolution of this field remain unclear.<h4>Objective</h4>This study intends to systematically review the application status and development …
Read PDFSystemic therapies for advanced hepatocellular carcinoma (HCC) have expanded considerably with the advent of tyrosine kinase inhibitors, immune checkpoint inhibitors and immunotherapy-anti-angiogenic combinations. However, despite this therapeutic diversification, first-line treatment selection remains largely empirical, as …
Read PDFThe interferon system, first discovered in chicken embryonated eggs, plays a pivotal role in defending vertebrates against pathogens, yet comprehensive multi-omics analyses of immune responses in avian species remain scarce. In this study, we employed …
Read PDF<h4>Background</h4>Necrotizing enterocolitis (NEC) is a life-threatening gastrointestinal disorder in neonates, and its early diagnosis remains challenging. RPS29, a ribosomal protein associated with cellular stress and inflammation, was identified as significantly differentially expressed in the discovery …
Read PDFBACKGROUND: Recently acquired Mycobacterium tuberculosis (M.tb) infection is associated with a higher risk of progression to active tuberculosis (TB), yet current diagnostic tools cannot distinguish recent from remote latent TB infection (LTBI). METHODS: Plasma samples …
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