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Apicomplexans are a diverse phylum of single-celled protists that are all obligate animal symbionts. The most well-studied members are severe pathogens of humans and livestock, such as the causative agents of malaria, cryptosporidiosis, toxoplasmosis, and …
Read PDFSorghum [Sorghum bicolor (L.) Moench], a C₄ cereal crop, is the fifth most widely cultivated cereal globally and is cultivated in over 100 countries for food, fodder, and biofuel production. Its exceptional resilience to abiotic …
Read PDFEvolution is often uneven in its pace and outcomes, with long periods of stasis interrupted by abrupt increases in morphological and ecological disparity. With thousands of gene histories, phylogenomics can uncover the genomic signatures of …
Read PDFPhylogenomics is a transformative approach in systematics, conservation biology, and biomedical research, enabling the inference of evolutionary relationships by leveraging hundreds to thousands of genes from genomic or transcriptomic data. However, acquiring high-quality genomes and …
Read PDFHere we present a time-calibrated phylogeny of 346 cycad accessions, covering ≈86% of the 380 accepted species, across all 10 extant genera, inferred from 1,409 single-copy nuclear loci (411,345 amino acid sites) derived from transcriptome …
Read PDFUltraconserved elements (UCEs) have become a powerful tool for phylogenomics, but probe sets optimized for one lineage often perform inconsistently when applied in others. Here, we designed and tested new UCE probe sets derived from …
Read PDFLeafhoppers of the genus Nephotettix (Hemiptera: Cicadellidae) are major vectors of rice tungro disease in Southeast Asia. Despite their economic significance, their evolutionary history, genomic adaptations, and associations with microbial symbionts remain poorly understood. Here, …
Read PDFUnderstanding the genomic toolkit that enabled animal terrestrialization, the shift from aquatic to terrestrial habitats, is key to uncovering the evolutionary origins of land biodiversity. Yet, the genomic basis of the physiological and metabolic adaptations …
Read PDFSternorrhyncha, one of the four major suborders of Hemiptera, represents a phytophagous insect clade comprising nearly 18,000 described species. While recent phylogenomic studies have made significant efforts to elucidate the internal phylogenetic relationships within this …
Read PDFAdvances in phylogenomics have greatly clarified fern evolutionary relationships, yet significant gaps remain. In this study, we performed phylogenetic and phylogenomic analyses of Polypodiineae, one of the most species-rich suborders of Polypodiales, and found that …
Read PDFThe Zingiberaceae family represents one of the most diverse monocot lineages in tropical Asia; however, the species delimitation of <i>Amomum</i> s.l. remains challenging due to morphological convergence and limited molecular evidence. This study analyzed transcriptomic …
Read PDFAtopic dermatitis (AD) is a complex chronic inflammatory skin disease driven by skin barrier dysfunction, immune dysregulation, and microbial imbalance. Traditional sampling methods, such as biopsies and blood collection, have provided valuable pathophysiological insights. However, …
Read PDFThyroid cancer comprises a heterogeneous group of malignancies with distinct clinical outcomes and molecular features, including papillary thyroid carcinoma (PTC), poorly differentiated thyroid carcinoma (PDTC), and anaplastic thyroid carcinoma (ATC). This study aimed to delineate …
Read PDFFragilariopsis cylindrus is a key diatom in the Southern Ocean, where low iron and manganese availability constrain primary production and biogeochemical activity. The molecular mechanisms used by polar diatoms, including F. cylindrus, to cope with …
Read PDFThe continuous risk of antibiotic resistance development underscores the demand for new agents with mechanisms distinct from existing antibacterial drugs. Here, we investigated HSI#6, a small-molecule antibacterial previously identified as a SecA activator, using integrated …
Read PDFUnderstanding neuronal differentiation and function requires precise proteomic characterization of distinct neuron types, yet existing methods face challenges in specificity and sensitivity. Here, we combine Methionine Analog-based Cell-Specific Proteomics and Interactomics (MACSPI) and SILAC to …
Read PDFIntermittent fasting (IF) has emerged as a powerful dietary intervention with profound metabolic benefits, yet the tissue-specific molecular mechanisms underlying these effects remain poorly understood. In this study, we employed comprehensive proteomics and transcriptomics analysis …
Read PDFMicroglia are implicated in the progression of Alzheimer's disease (AD) pathology from its earliest stages, suggesting that cerebrospinal fluid (CSF) microglia profiling across clinical AD stages can aid in treatment development and monitoring. We analyzed …
Read PDFProteins exist as multiple chemical and sequence-specific proteoforms, each of which may serve as a critical mediator of physiological or pathological signalling. This diversity arises from processes such as alternative splicing of gene transcripts, translation …
Read PDF<h4>Background</h4>Brain metastasis (BrM) is a leading cause of mortality in patients with lung adenocarcinoma (LUAD). Extracellular vesicles (EVs), which carry bioactive molecules, play a critical role in tumor microenvironment remodeling and exhibit metastatic organotropism, holding …
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