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'Huizao' is a leading jujube (Ziziphus jujuba Mill.) variety valued for its high-quality dry fruit. Using PacBio HiFi long reads and Hi-C data, we generated a high-quality, chromosome-level, haplotype-resolved genome assembly for this cultivar, with …
Read PDFThe increasing availability of reference genomes for non-traditional model species is enhancing research in ecology and evolution. Here, we present a high-quality chromosome-level genome assembly and annotation for the bank vole Clethrionomys glareolus, an emerging …
Read PDFThe cellular origin and molecular mechanisms underlying therapeutic resistance in colorectal cancer remain largely unclear.This study integrates single-cell transcriptomics, spatial transcriptomics, molecular docking, and multi-cohort public databases to systematically elucidate the epithelial cell-driven drug resistance …
Read PDF<h4>Introduction</h4>Hereditary α-tryptasemia (HαT), defined by increased <i>TPSAB1</i> copy number and elevated basal serum tryptase, is associated with mast cell (MC)-mediated symptoms. However, its role in gastrointestinal disease remains unclear. Because intestinal MCs express the non-IgE-dependent …
Read PDFMillets are a diverse group of small seeded grasses that have long served as vital staple foods and forage crops across a wide range of agro-ecological regions. Known for their exceptional adaptability to marginal and …
Read PDFSome patients suspected of infection may have potential causes, such as tumors, but conventional examination methods are negative. Copy number variation (CNV) analysis based on metagenomics next generation sequencing (mNGS) can simultaneously detect pathogenic microorganisms …
Read PDFLong-read whole-genome sequencing (LR-WGS) technologies enhance the discovery of structural variants (SVs) and tandem repeats (TRs). We performed LR-WGS on 267 individuals from 63 autism spectrum disorder (ASD) families and generated an integrated call set …
Read PDFBACKGROUND: Toxoplasma gondii is an important pathogen and model organism for studying mechanisms of immune evasion and defense. Within the same strain, model organisms are typically assumed to be isogenic; for T. gondii, within-strain genetic …
Read PDFClinical pharmacogenomics (PGx) testing strategies are mainly based on targeted PCR, microarrays, or short-read sequencing. These methods perform well for detecting known single-nucleotide variants (SNVs), small insertions/deletions (indels), and certain copy number variants (CNVs), but …
Read PDFLong-read sequencing (LRS) is rapidly advancing and demonstrates considerable promise in hematological malignancies. At the 2025 ASH meeting, numerous studies highlighted advances in applying LRS across diverse hematological malignancies. Rapid LRS-based whole-genome sequencing and adaptive …
Read PDF<h4>Objectives</h4>Central nervous system (CNS) metastasis is a major driver of morbidity in metastatic breast cancer, yet the molecular determinants of CNS tropism remain incompletely defined. LYN, a Src-family kinase integrating receptor tyrosine kinase and integrin …
Read PDF<b>Background</b>: Familial hemiplegic migraine (FHM) is a rare and severe form of migraine disorder featuring aura symptoms that include hemiplegia during attacks. While pathogenic missense variants in <i>CACNA1A</i>, <i>ATP1A2</i>, and <i>SCN1A</i> can cause FHM or …
Read PDFRoses are economically important ornamental plants, with widespread applications in the cut flowers, garden and cosmetics industries. The genomic evolution and diversity of the subgenus Rosa remain understudied, limiting exploitation of its diversity in breeding. …
Read PDFThe mechanisms driving rapid plant diversification-often referred to as Darwin's "abominable mystery"-remain a central question in evolutionary biology. Elucidating the genomic basis of rapid speciation and morphological innovation, such as those observed in the Brassicaceae, …
Read PDFThe comparison of chromosome-level genomes allows biologists to investigate new axes of organismal evolution. Spiders comprise a significant proportion of known arachnid diversity, with many complex morphologies and unique natural histories, yet comparative genomics in …
Read PDFAdvances in genomics have facilitated the delineation of fisheries management units, which can be challenging in systems such as large lakes, in which high gene flow tends to limit genetic structure. In Great Slave Lake, …
Read PDFBACKGROUND: Kelch repeat F-box (KFB) proteins are substrate-recognition components of SCF (SKP1-CULLIN1-F-box) E3 ubiquitin ligases and play important roles in protein turnover, specialized metabolism, and stress responses in plants. However, the evolutionary history of the …
Read PDFBreeding root, tuber, and cereal crops faces the critical challenge of unlocking extensive genetic variation and addressing complex gene-environment interplays to boost yield, quality, and resilience. Recent technological advances in pangenomics, multi-omics data integration, and …
Read PDFRainbow trout (Oncorhynchus mykiss) exhibit extensive genomic diversity shaped by domestication, life history and geographic origin. To advance the development of a comprehensive pangenome reference, we present new de novo genome assemblies of two genetically …
Read PDFBACKGROUND: Duchenne muscular dystrophy (DMD) is an X-linked disorder caused by mutations in the DMD gene. Reports of DMD resulting from complex structural variants involving the DMD gene are rare, partly because such variants are …
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