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<h4>Background</h4>Metabolic dysfunction-associated steatohepatitis (MASH), the progressive phenotype of metabolic dysfunction-associated steatotic liver disease (MASLD), is well recognized for its increased risk of progressing to cirrhosis and hepatocellular carcinoma (HCC). However, early diagnosis and identification of …
Read PDFBreast cancer stem cells (BCSCs) have been proposed as the cause of resistance to conventional treatments and of breast cancer recurrence and metastasis. This study provides compelling evidence for the role of the transcription factor …
Read PDFAutophagy is an evolutionarily conserved catabolic process. In a process requiring a cascade of over 35 autophagy-related genes (Atg), a cupped phagophore membrane expands to surround cytoplasmic material, and seals itself to form an autophagosome, …
Read PDF<h4>Background</h4>Histidine (His) ammonia Lyase (HAL) is a key rate-limiting enzyme that catalyzes the first reaction in the metabolism of histidine. Deficiencies in HAL lead to histidinemia, characterized by elevated levels of His in the blood …
Read PDFRNA molecules localize to specific subcellular compartments to perform their biological functions correctly. However, the mechanisms underlying RNA transport and subcellular localization remain poorly understood. In this study, we introduced SRLE-seq (Screening RNA Localization Elements …
Read PDFAn emerging hallmark of many human diseases is transcription of typically silenced repetitive DNA containing pathogen-associated molecular patterns (PAMPs). These PAMPs engage the innate immune system via pattern recognition receptors (PRRs)-a phenomenon known as viral …
Read PDFIntestinal epithelial cells (IECs) are capable of mounting an adequate antimicrobial inflammatory response to pathogens while tolerating commensals. The underlying regulatory mechanisms of immune sensitivity remain incompletely understood, particularly in the context of human IECs. …
Read PDFClonal hematopoiesis (CH) increases with age and is associated with severe outcome in the course of infections or tumor development. Understanding the environmental conditions that favor mutant clones and the CH immune system response to …
Read PDFCoronary vascularization and sympathetic innervation are tightly coordinated during heart development and are essential for normal cardiac function. Here, we present a self-organized human iPSC-derived epicardium-myocardium organoid (EMO) that mimics heart vascular plexus development and …
Read PDFDehydration-responsive element-binding (DREB) transcription factors play an important role in plant responses to drought. DREB subfamily A4 contains a subgroup named TINY. Previous studies in Arabidopsis suggest that TINYs suppress plant growth and mediate abscisic …
Read PDFThe fungus <i>Aspergillus melleus</i> is an important biosynthesis host for varied commercial applications. Gene annotation of a previously published genome produced 12,841 protein-coding genes and identified 102 biosynthetic gene clusters.
Read PDFThyroid tumors represent 1-4% of cancers in both dogs and humans. Most canine tumors are follicular (FTC) or medullary carcinomas (MTC), unlike humans, where only 10-15% are FTC and 2% are MTC, with BRAF/NRAS or …
Read PDFNonsense-mediated mRNA decay (NMD) is an RNA quality control pathway that degrades transcripts containing premature termination codons (PTCs). While the role of NMD in modulating tumor antigenicity and immune evasion is increasingly appreciated, its interaction …
Read PDFThe intestinal epithelium is a highly regenerative tissue organized along the crypt-villus axis, where spatially compartmentalized gene expression governs stem cell renewal, proliferation, and differentiation. Super-enhancers (SEs) are large clusters of regulatory elements densely bound …
Read PDFPremenopausal women preferentially store fat in subcutaneous depots, which provides protection against cardiometabolic disease. Their white adipose tissue also exhibits a more thermogenic, brown-like profile compared with that of men, yet the mechanisms underlying this …
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