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Scientific literature is being published at an exponential rate, including in the field of mammalian cell bioprocessing. At the same time, the research landscape is becoming more diverse, with the emergence of multiple specialised subfields. …
Read PDFUp to one-third of patients with localized colorectal cancer (CRC) relapse after curative-intent resection, as conventional markers like carcinoembryonic antigen (CEA) and scheduled CT/MRI often fail to detect micro-metastatic disease early. Advanced imaging, particularly radiomics, …
Read PDF<h4>Background</h4>Chronic interpersonal stress has been linked to accelerated biological aging, but questions remain about which relationship stress domains may be most consequential during midlife.<h4>Research design and methods</h4>Linear regression models quantified the cross-sectional associations between domain-specific …
Read PDFPresbycusis, or age-related hearing loss (ARHL), is a multifactorial disorder characterized by a gradual, bilateral sensorineural decline in hearing sensitivity, predominantly affecting high-frequency sounds. It is one of the most common chronic conditions in the …
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Read PDFAlthough vaccination remains one of the most impactful interventions in contemporary public health, with consistent and widely documented reductions in morbidity and mortality, the traditional empirical development of vaccines-largely based on trial-and-error strategies-still reflects an …
Read PDFDNA methylation is a widely studied epigenetic mark and a powerful biomarker of cell type, age, environmental exposures, and disease. Whole-genome sequencing following selective conversion of unmethylated cytosines into thymines via bisulfite treatment or enzymatic …
Read PDF<h4>Objectives</h4>FAM83H is a critical gene implicated in amelogenesis imperfecta type IIIA (AI type IIIA), but its precise role in enamel formation remains poorly understood. Fragmented datasets, inconsistent terminology, and limited integrative analyses hinder functional interpretation. …
Read PDFThe elevated mortality associated with colorectal cancer is largely due to delayed diagnosis and post-treatment disease recurrence, highlighting the urgent clinical need for molecular markers with exceptional sensitivity and specificity to support early detection and …
Read PDFUnderstanding the dysregulation of complex biological pathways is essential for uncovering molecular mechanisms and identifying novel therapeutic opportunities for complex diseases. In recent years, deep learning (DL) models have shown great potential in modeling biological …
Read PDFAutism spectrum disorder (ASD) encompasses a wide and diverse range of neurodevelopmental conditions, characterized by difficulties with social communication along with restricted and repetitive patterns of behavior [...].
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