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Pre-implantation mammalian development culminates in the blastocyst, where embryonic and extra-embryonic tissue founders reside. However, species variations in the underlying mechanisms, starting from zygotic genome activation (ZGA), remain underexplored. In this issue of Cell Genomics, …
Read PDFSpatial multi-omics enables the exploration of tissue microenvironments and heterogeneity from the perspective of different omics modalities across distinct spatial domains within tissues. To jointly analyze the spatial multi-omics data, computational methods are desired to …
Read PDFMini-livestock refers to small vertebrates and invertebrates used as human food, animal feed, or for other beneficial purposes. They represent sustainable alternatives to conventional livestock, whose potential is now being revealed through advances in omics …
Read PDFThe scPrediXcan framework enables cell-type-specific transcriptome-wide association studies (TWASs) by integrating deep learning-based prediction of gene expression from DNA sequence and epigenetic features. We present a protocol for scPrediXcan: training cell-type-specific models for expression prediction, …
Read PDFRheumatoid arthritis (RA) is a heterogeneous autoimmune disease characterized by variable clinical manifestations and a complex, often unpredictable disease trajectory, which hinders early diagnosis and personalized treatment. This review highlights recent breakthroughs in biomarker discovery, …
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Read PDFRheumatoid arthritis (RA) is a multifaceted autoimmune disease that is marked by a complex molecular profile influenced by an array of factors, including genetic, epigenetic, and environmental elements. Despite significant advancements in research, the precise …
Read PDFBipolar affective disorder (BD) is a severe mental illness characterized by recurrent episodes of mania, hypomania, and depression, accompanied by progressive neurobiological changes that go beyond the classical concepts of neurotransmitter dysregulation. Increasing evidence points …
Read PDFRuminant livestock-cattle, sheep, and goats-are cornerstones of global food security, collectively providing meat, milk, fiber, and other essential products that sustain the livelihoods of hundreds of millions of people across diverse agro-ecological zones [...].
Read PDFToxicology is shifting toward predictive, mechanism-based approaches that support quicker, more human-relevant risk assessments and reduce reliance on animal testing. Central to this shift are short-term in vivo studies enriched with omics endpoints, which provide …
Read PDFAccurate diagnosis of PM and precise histologic subtyping are critical for optimal therapeutic decision-making, as treatment strategies-including chemotherapy, immunotherapy, or multimodality approaches-are largely subtype-dependent. Because of the several-decade latency between fiber inhalation and symptom onset, …
Read PDFThe therapeutic landscape of lung cancer treatment is moving from a one-size-fits-all approach to a more personalized one [...].
Read PDF<h4>Background</h4>Lung cancer remains the leading cause of cancer-related mortality worldwide, highlighting the urgent need for earlier detection within real-world screening and patient management pathways. Recent advances in multi-omics technologies have created new opportunities for identifying …
Read PDFHow can we effectively integrate and represent heterogeneous multi-omics data to better understand complex biological systems and support the development of personalized digital models? The growing availability of high-dimensional omics data across different molecular scales …
Read PDFExpression quantitative trait loci (eQTLs) are regulatory variants that affect the expression level of their target genes and have significant impact on disease biology. However, eQTL mapping has been done mostly in one tissue at …
Read PDFThe integration of multi-omics data has become crucial in understanding the complexity of biological systems and disease mechanisms. However, the high dimensionality and heterogeneity of such data present significant analytical challenges. This review investigates the …
Read PDFThis review provides a representative overview of public biomedical databases and their use in biomedical research. These resources are categorized into four major types according to their dominant data content: public health databases, clinical databases, …
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