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Omics approaches have emerged as indispensable tools in unravelling the intricate molecular landscape of cardiovascular disease (CVD) by providing comprehensive insights into the underlying mechanisms driving CVD pathogenesis, progression, and response to therapy. Integrative omics …
Read PDFCancer nanomedicine has emerged as a transformative approach in oncology, providing targeted therapeutic strategies with enhanced efficacy and reduced systemic toxicity. The integration of multi-omics technologies has further revolutionized this field.This review was conducted based …
Read PDFLong non-coding RNAs (lncRNAs) are receiving increasing attention as biomarkers for cancer diagnosis and therapy. Although there are many computational methods to identify cancer lncRNAs, they do not comprehensively integrate multi-omics features for predictions or …
Read PDF<b>The</b> World Health Organization identifies environmental pollution as a primary global health threat, and its role in the onset and progression of neurological diseases is becoming increasingly clear. In the era of precision medicine, understanding …
Read PDFWhen using traditional approaches, such as pharmacokinetics and pharmacodynamics, the entire cellular or molecular response to drugs in the body cannot be fully ascertained or established. The oral medication process involves pharmacokinetics, followed by oral …
Read PDFChromatin immunoprecipitation sequencing (ChIP-seq) is a widely used technique for identifying transcription-factor binding and histone modifications across the genome. Peaks in ChIP-seq data vary in length depending on the biological context, from narrow transcription factor …
Read PDFTrees are long-lived plants characterized by the development of highly branched shoot systems. Along these structures, somatic mutations arise and may become fixed in reproductive tissues such as flowers and fruits. Because mature trees produce …
Read PDFRecent advances in multi-omics and spatial proteomics are reshaping our understanding of Alzheimer's disease. Guo et al.<sup>1</sup> applied integrative multi-omics to stratify mild cognitive impairment into biologically distinct subtypes with divergent progression trajectories: one metabolically …
Read PDFCrop improvement remains central in addressing global challenges related to food security, climate change, and sustainable agriculture [...].
Read PDFGenomic imprinting is an epigenetic occurrence that results in the expression of alleles specific to the parent of origin, plays pivotal roles in plant development, stress adaptation, and agronomic trait regulation. While imprinting has been …
Read PDF[This corrects the article DOI: 10.1016/j.gendis.2022.11.024.].
Read PDFColorectal cancer (CRC) remains a heterogeneous disease for which improved molecular stratification is needed across the clinical pathway. Multi-omics technologies have expanded insight into CRC biology, and artificial intelligence (AI) has created new possibilities for …
Read PDFWeight stigma remains a major public health issue that negatively impacts individuals living with obesity. This study explores its prevalence in the Spanish adult population and examines whether viewing obesity as a disease influences societal …
Read PDFThere is no immunohistochemical or molecular marker to confirm the histologic diagnosis of pancreatic ductal adenocarcinoma (PDAC). This is particularly important in a scenario of unknown primary. Molecularly, PDAC is characterized by a limited set …
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Read PDFHistone modifications (HMs) and transcription factors (TFs) are central to chromatin dynamics and transcriptional regulation. Conventional bulk approaches like ChIP-seq require large cell populations, limiting applicability to heterogeneous studies and tissue samples. In contrast, single-cell …
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