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High-conflict parental divorce can result in parental alienation (PA), leading to chronic psychological stress in children that adversely affects their mental and physical health. This stress may manifest as anxiety, depression, eating disorders, immune dysfunction, …
Read PDF<h4>Background</h4>Chemoradiotherapy (CRT) remains the standard practice for patients with nonsurgical esophageal squamous cell carcinoma (ESCC). However, the impact of radiation duration is poorly understood. We aimed to determine the effect of CRT duration on the …
Read PDFGliomas are among the most malignant and aggressive tumors of the central nervous system, characterized by the absence of early diagnostic markers, poor prognosis, and a lack of effective treatments. Advances in high-throughput technologies have …
Read PDFRecent breakthroughs in spatial multi-omics enable simultaneous profiling of different modalities while preserving tissue architecture, providing unprecedented opportunities to explore tissue complexity. However, due to the sparse and noisy nature of the data, interpreting these …
Read PDF<h4>Background</h4>Gastric cancer remains a major cause of cancer-related morbidity and mortality. Despite advances in surgical and perioperative care, prolonged hospitalization continues to strain healthcare systems. Predicting postoperative length of stay (LOS) could support personalized care …
Read PDFThe term "epigenetics" comes from the union of the words "epigenesis" and "genetics", coined by the British embryologist Conrad Waddington in 1942 [...].
Read PDFAlzheimer’s Disease (AD) is a progressive and ultimately fatal neurodegenerative disorder, representing the most common form of dementia and affecting nearly 7 million people in the United States. For over a century, research has centered …
Read PDFArtificial intelligence (AI) is transforming many fields, including healthcare and medicine. In biomarker discovery, AI algorithms have had a profound impact, thanks to their ability to derive insights from complex high-dimensional datasets and integrate multi-modal …
Read PDFThis commentary highlights a study revealing that stomatal lineage precursor cells can be reprogrammed into somatic embryos through a LEC2-SPCH-YUC auxin regulatory circuit. This study uncovers a developmental route to plant totipotency and offers promising …
Read PDFIn recent years, the integration of genetic and epigenetic insights has significantly enriched our understanding of dementia's complex neurobiology [...].
Read PDFA proposed mechanism of how early life microbiota predisposes to later metabolic syndrome.
Read PDF<b>Background:</b> Serum concentrations of 25-hydroxyvitamin D [25(OH)D] are associated with the risk of several chronic and acute diseases. However, updated data on vitamin D status in Mediterranean countries, including Italy, remain limited, hindering effective public …
Read PDF<h4>Introduction</h4>This study analysed the opinions and perceptions of Spanish physicians towards the management of people newly diagnosed with type 2 diabetes (T2D) aged ≤ 65 years.<h4>Methods</h4>Online survey targeting primary care physicians (PCPs) and endocrinologists (members …
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