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Integrating Artificial Intelligence in Next-Generation Sequencing: Advances, Challenges, and Future Directions
The integration of artificial intelligence (AI) into next-generation sequencing (NGS) has revolutionized genomics, offering unprecedented advancements in data analysis, accuracy, and scalability. This review explores the synergistic relationship between AI and NGS, highlighting its transformative …
Read PDFEpigenomics coverage data extraction and aggregation in R with tidyCoverage
<h4>Summary</h4>The tidyCoverage R package provides a framework for intuitive investigation of collections of genomic tracks over genomic features, relying on the principle of tidy data manipulation. It defines two data structures, CoverageExperiment and AggregatedCoverage classes, …
Read PDFDeep learning-driven multi-omics analysis: enhancing cancer diagnostics and therapeutics
Artificial intelligence (AI) excels at efficiently processing large volumes of data and extracting valuable insights. Deep Learning (DL), a subfield of AI, utilizes multi-layer neural network algorithms to analyze various types of data, mimicking the …
Read PDFDNA methylation biomarkers for the diagnosis and treatment management of breast cancer: where are we now?
Breast cancer is one of the most commonly diagnosed cancers worldwide and is a significant contributor to the global cancer burden. It is a clinically heterogeneous disease and reliable tools are needed to support treatment …
Read PDFRegenerative Approaches to Enhance the Skin Microenvironment and Boost Aesthetic Efficacy: A Narrative Review
Aesthetic medicine is shifting from symptomatic correction to biological structural restoration. Regenerative aesthetics represents a frontier in dermatology, focusing on the restoration of the skin microenvironment to enhance cellular vitality and tissue resilience. Central to …
Read PDFEZH2 inhibition enhances the activity of Carboplatin in aggressive-variant prostate cancer cell lines
<h4>Background</h4>Aggressive Variant Prostate Cancers (AVPCs) are incurable malignancies. Platinum-based chemotherapies are used for the palliative treatment of AVPC. The Polycomb Repressive Complex 2 (PRC2) promotes prostate cancer progression <i>via</i> histone H3 Lysine 27 tri-methylation (H3K27me3). …
Read PDFMulti-omics in immunotherapy research for HNSCC: present situation and future perspectives
Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer worldwide, significantly impacting patient survival and quality of life. The recent emergence of immunotherapy has provided new hope for HNSCC patients, improving …
Read PDFTumor derived adiponectin induces immunosuppressive macrophages in upper tract urothelial carcinoma
Upper tract urothelial carcinoma (UTUC) is a rare urologic cancer that is more aggressive and has a poorer survival rate compared to bladder cancer. Previously, we linked the UTUC derived factors with tumor-infiltrating immune cells. …
Read PDFBeyond Labels: Can Biomarkers and Treatable Traits Revolutionize Interstitial Lung Disease Care?
The classification of interstitial lung disease (ILD)s has traditionally relied on well-defined diagnostic labels, such as idiopathic pulmonary fibrosis (IPF), nonspecific interstitial pneumonia (NSIP), and hypersensitivity pneumonitis (HP) [...].
Read PDFOmics Sciences in Regular Physical Activity
The multiple health benefits of regular physical activity are well known and are the results of exercise adaptations. The study of physical training biology is not straightforward since it involves organ crosstalk and depends on …
Read PDFDevelopment and validation of a novel cell type estimation method for targeted bisulfite sequencing data
<h4>Aims</h4>Epidemiological studies of DNA methylation often use buccal swabs, which contain mixtures of cell types, but no low-cost methods exist for statistical correction in candidate gene studies using targeted bisulfite sequencing. This study aims to …
Read PDFVariant-to-Biomarker Pathways in Peripheral Artery Disease: Multiomics Integration and Clinical Translation
Peripheral artery disease (PAD) is a prevalent, disabling manifestation of systemic atherosclerosis that carries high risks of major adverse cardiovascular and limb events, yet remains incompletely explained by conventional risk factors and haemodynamic indices. Although …
Read PDFRetraction: Circular RNA circ-0016068 promotes the growth, migration, and invasion of prostate cancer cells by regulating the miR-330-3p/BMI-1 axis as a competing endogenous RNA
[This retracts the article DOI: 10.3389/fcell.2020.00827.].
Read PDFArtificial Intelligence and Multi-Omics in Pharmacogenomics: A New Era of Precision Medicine
Pharmacogenomics is entering a transformative phase as high-throughput "omics" techniques become increasingly integrated with state-of-the-art artificial intelligence (AI) methods. Although early successes in single-gene pharmacogenetics reported clear clinical benefits, many drug response phenotypes are governed …
Read PDFAn optimal workflow scheduling in IoT-fog-cloud system for minimizing time and energy
Today, with the increasing use of the Internet of Things (IoT) in the world, various workflows that need to be stored and processed on the computing platforms. But this issue, causes an increase in costs …
Read PDFDeep Learning-Enabled Multi-Omics Integration: A New Frontier in Precise Drug Target Discovery
Precise drug target discovery is pivotal to mitigating the escalating costs and high attrition rates that characterize pharmaceutical research and development. Given that traditional single-omics methods often fail to elucidate the systemic complexity of human …
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