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The NEAT1/miR-124-3p/CCL2 axis in chronic kidney disease progression: integrated bioinformatics analysis and experimental validation
<h4>Background</h4>Chronickidney disease (CKD) is a major global health burden lacking effectivetherapies. Renal interstitial fibrosis (RIF) is a key pathological driver ofCKD progression. This study aimed to identify novel diagnostic biomarkers and therapeutictargets.<h4>Research design and methods</h4>Weanalyzed …
Read PDFThe Future of Interventional Keratoconus Management: Perspectives on Integrating Epithelium-on Oxygen-Enriched Cross-Linking into Comprehensive Care Pathways
This perspective presents a new conceptual framework for the comprehensive care of patients with keratoconus. Keratoconus is an ectatic degeneration of the cornea associated with progressive vision loss and diminished quality of life. Until recently, …
Read PDFCurrent Bioinformatics Tools in Precision Oncology
Integrating bioinformatics tools has profoundly transformed precision oncology by identifying essential molecular targets for personalized treatment. The rapid development of high-throughput sequencing and multiomics technologies creates complex datasets that require robust computational methods to extract …
Read PDFPlant MIR2911 in honeysuckle is effective against SARS-CoV-2 variant
The COVID-19 pandemic remains a global health challenge, with the emergence of new SARS-CoV-2 variants complicating treatment and prevention efforts. MIR2911, a plant-derived microRNA from honeysuckle, has shown antiviral activity against the original strain of …
Read PDFMapping Genetic Regulation of Transcription to Identify Functional Variants and Genes Associated with Pancreatic Cancer Risk
Pancreatic cancer is one of the most lethal malignancies. Genome-wide association studies (GWAS) identify multiple susceptibility loci, but most map to noncoding regions, leaving variant-to-gene links unresolved. In this study, a genome-wide regulatory map is …
Read PDFNew Insights into the Clinical Characterization of SDHAF2-related Familial Paraganglioma Syndrome
<h4>Background</h4>The clinical characterization of SDHAF2-related familial paraganglioma syndrome remains elusive. The aim of this study is to contribute to the knowledge of this syndrome with valuable new information.<h4>Methods</h4>A total of 56 individuals with the p.(Gly78Arg) …
Read PDFMachine Learning for Predicting Stroke Risk Stratification Using Multiomics Data: Systematic Review
<h4>Background</h4>Stroke is a complex, multidimensional disorder influenced by interacting inflammatory, immune, coagulation, endothelial, and metabolic pathways. Single-omics approaches seldom capture this complexity, whereas multiomics techniques provide complementary insights but generate high-dimensional and correlated feature spaces. …
Read PDFFunctional genomic analysis reveals HAVCR1 as the key regulator of 5q33.3 locus linked to hyperlipidemia
Hyperlipidemia is a major risk factor for atherosclerosis and other serious cardiovascular diseases, yet it often presents without obvious symptoms in the absence of comorbidities, complicating early detection and management. Given the high heritability of …
Read PDFPerspectives on emerging challenges and training needs for the Laboratory Medicine specialist of the future
Laboratory Medicine has undergone a radical transformation since its early 20th-century origins, evolving from rudimentary hospital laboratories into a technologically advanced discipline. Laboratory Medicine specialists now play multifaceted roles that extend beyond traditional analytical tasks …
Read PDFBeyond single biomarkers: multi-omics strategies to predict immunotherapy outcomes in blood cancers
Immunotherapy has revolutionized hematologic cancer treatment, yet responses remain unpredictable due to primary resistance, relapse, and life-threatening toxicities. Conventional biomarkers fail to capture the complexity of tumor-immune interactions, necessitating integrative approaches. This review explores how …
Read PDFLiraglutide prevents lupus-associated diffuse alveolar hemorrhage via inhibiting lymphocyte infiltration and promoting macrophage M2 polarization
<h4>Objectives</h4>This study aimed to explore the prophylactic and therapeutic role of liraglutide for lupus-associated diffuse alveolar hemorrhage (DAH).<h4>Methods</h4>A lupus-associated DAH model was established in 6-8-week-old female C57BL/6 mice via intraperitoneal injection of 0.5 mL pristane. …
Read PDFObestatin: canonical and unexpected functions
The functions of appetite-regulating hormones have been studied for decades with the aim of finding a solution to the problem of obesity. Among these molecules, a small peptide called obestatin has emerged as an anorexigenic …
Read PDFBTS: a scalable Bayesian Tissue Score for prioritizing GWAS variants and their functional contexts across >1000s of omics datasets
<h4>Motivation</h4>statistics from genome-wide association studies (GWAS) are widely used in fine-mapping and colocalization analyses to identify causal variants and their enrichment in functional contexts, such as affected cell types and genomic features. With the expansion …
Read PDFSpecial Issue: Latest Research on Plant Genomics and Genome Editing
Over the past ten years, plant science has undergone a remarkable transformation driven by the convergence of next-generation sequencing, increasingly sophisticated bioinformatics tools, and the rise of targeted genome editing platforms [...].
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