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<h4>Background</h4>Stomach adenocarcinoma (STAD) is a common malignant tumor within the digestive system, characterized by significant morbidity and mortality rates. The identification of innovative biomarkers or therapeutic targets for STAD is of utmost importance. A deeper …
Read PDFAndrogenetic alopecia (AGA) is associated with follicular miniaturization, oxidative stress, and microinflammation. Hydroxytyrosol (HT) has antioxidant and anti-inflammatory activities, but its mechanisms in AGA remain unclear. Differentially expressed genes (DEGs) from GSE212301 were intersected with …
Read PDF<h4>Motivation</h4>Low-complexity (LC) DNA sequences are compositionally repetitive sequences that are often associated with spurious homologous matches and variant calling artifacts. While algorithms for identifying LC sequences exist, they either lack concise mathematical definition of complexity …
Read PDFMinimal residual disease (MRD) is the most robust independent prognostic biomarker for pediatric acute lymphoblastic leukemia (ALL). Conventional MRD detection assays suffer from insufficient sensitivity and inherent technical limitations, failing to identify ultra-low-level leukemic blasts …
Read PDF<h4>Background</h4>Breast cancer continues to be the leading global health concern and cause of cancer-related deaths among women, with about 20 million new cases and 9.7 million deaths estimated globally based on GLOBOCAN 2022 data. Breast …
Read PDFThe traditional paradigm of pharmaceutical research is characterized by substantial inefficiency, requiring extensive timelines and billions of dollars while suffering from high clinical attrition rates. The integration of generative artificial intelligence (AI) is driving a …
Read PDFCancer immunotherapy, which leverages the immune system to combat tumor cells, has made significant advancements in oncology treatment in recent years. Yet significant challenges remain in predicting treatment responses and understanding mechanisms of resistance. Artificial …
Read PDFComplex traits in plants are typically governed by multiple genes, making their genetic analysis a long-standing challenge in plant research [...].
Read PDFThe knowledge accumulated over the past two decades has revealed that the natural history of metabolic dysfunction-associated steatotic liver disease (MASLD) and the drivers of the disease severity are not only complex but also exhibit …
Read PDF<h4>Aims</h4>This research aims to establish a chromatin regulator (CR) signature to provide new epigenetic insights into the pathogenesis of primary open-angle glaucoma (POAG).<h4>Materials & methods</h4>The expression profile of CRs in trabecular meshwork (TM) tissues was …
Read PDFCardiovascular disease (CVD) is the leading cause of illness and death worldwide. Numerous studies have been conducted into the underlying mechanisms and molecular characteristics of CVD using various omics approaches. However, there is still a …
Read PDFDecades of advances unfolding in parallel across diverse domains have delivered to science rapid rises in the scale of multiplexing, population-level cohort sizes, global computational capacity, massive-scale artificial intelligence (AI) models, and advanced human cellular …
Read PDFTranscriptional regulation is a central and finely orchestrated process through which cells control gene expression in a spatially and temporally coordinated manner [...].
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