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Phosphate deficiency reduces nodule formation in various legumes, which hinders nitrogen fixation and crop yield. We previously showed that phosphate deficiency reduces nodule formation by activating the autoregulation of nodulation (AON) pathway. We also observed …
Read PDF<b>Background</b><b>/Objectives</b>: Pest management strategies rely on insecticides such as deltamethrin (DM), a commonly applied type II pyrethroid. As a natural component of food-associated microflora, <i>Saccharomyces cerevisiae</i> inevitably encounters DM residues in crops used for fermentation …
Read PDFLipophagy is a form of selective autophagy that targets the lipid droplets for lysosomal decay and has been implicated in the onset and progression of metabolic dysfunction-associated steatotic liver disease (MASLD). Factors that augment lipophagy …
Read PDFFacioscapulohumeral muscular dystrophy (FSHD) is an autosomal dominant muscular disease in which genetic mutations activate DUX4 expression in skeletal muscle. Currently, there are no approved therapies for FSHD. We developed Delpacibart braxlosiran (del-brax, also known …
Read PDFSweet potato (Ipomoea batatas) exhibits diversity in pigmentation and leaf morphology, yet the genetic architecture and regulatory organisation underlying these traits remain poorly resolved, particularly with respect to organ-specific control. We hypothesised that phenotypic variation …
Read PDFThe polarization of naive CD4+ T cells into Th2 cells is initiated in lymphoid organs and completed as the cells become tissue resident, where they express ST2, the receptor for the alarmin interleukin (IL)-33, which …
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Read PDFCancer immunotherapy aims to boost T cell responses against tumor cells. However, a large fraction of patients with cancer exhibit intrinsic or acquired resistance to immunotherapy. To better understand resistance mechanisms in tumor cells, we …
Read PDFPatients diagnosed with cancer of unknown primary (CUP) have poor prognoses, highlighting the need to identify primary sites for targeted therapeutic intervention. Here, we present a protocol to predict the primary sites of CUP based …
Read PDFItaconate is produced by inflammatory macrophages and promotes negative feedback on inflammation. It is synthesized by aconitate decarboxylase 1 (ACOD1) from cis-aconitate, a metabolite of the tricarboxylic acid cycle. Here, we focused on the role …
Read PDFLamin B1 is a structural component of the nuclear lamina that participates in genome organization and transcriptional control. During adaptive immune responses, B lymphocytes in germinal centers (GCs) undergo clonal expansion and programmed DNA damage …
Read PDF<h4>Background</h4>Diabetic foot ulcer (DFU), a condition marked by high rates of recurrence, amputation, and mortality, represents one of the major challenges in diabetes management. RNA-binding proteins (RBPs) are pivotal for post-transcriptional regulation in diabetic complications. …
Read PDFThe advent of comprehensive genomic sequencing has catalysed the emergence of paediatric precision medicine platforms globally. These have established the feasibility of profiling tumours at scale, enhancing our understanding of the genetic landscape of paediatric …
Read PDFThe <i>Plasmodium</i> ookinete is a unique invasive stage which is formed following the fertilization of gametes in mosquito midguts after ingestion of infected mammalian blood. Unlike merozoites and sporozoites, ookinetes do not differentiate and proliferate …
Read PDFCAR-T cell therapy is effective in hematologic malignancies but remains challenging in solid tumors owing to antigen heterogeneity and tumor microenvironment-induced exhaustion. Here, gene editing of the nuclear receptor NR2F6 restores CAR-T cell functionality, sustaining …
Read PDF<h4>Background</h4>Invasive lobular carcinoma (ILC) is the second most common histological subtype of breast cancer after invasive ductal carcinoma of no special type (NST), accounting for 10-15% of diagnoses. Despite the myriad molecular, histological and clinical …
Read PDFIL-1β-expressing macrophages have been described in rheumatoid arthritis (RA), immune checkpoint inhibitor-induced inflammatory arthritis (ICI-arthritis), and pancreatic cancer and proposed to be pathogenic. IL-1β+ macrophages express genes cooperatively induced by PGE2 and TNF signaling, but …
Read PDFCilia are microtubule-based structures lining epithelial surfaces of many organs and play an essential role in diverse metabolic and developmental processes. Structural or functional disruptions of cilia can lead to ciliopathies affecting multiple organs. Knocking …
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