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<h4>Summary</h4>SyntenyQC is a data pre-processing tool for the construction of synteny plots. It supports genomic data collection, annotation and dereplication to facilitate (and in some cases fundamentally enable) the construction of informative synteny plots.<h4>Availability and …
Read PDFCarbapenem-resistant <i>Escherichia coli</i> (CREC) represent a major clinical threat because of limited treatment options and frequent multidrug resistance. While rapid molecular diagnostics improve treatment outcomes, the detection of carbapenemase genes, such as <i>bla</i> <sub>OXA-48</sub>-like, does …
Read PDF<h4>Background</h4>Silica nanoparticles (SiNPs) are extensively produced and utilized, leading to regular human exposure in both living environmental and occupational settings. Numerous studies have confirmed the detrimental effects of SiNPs on respiratory health. Neutrophil extracellular traps …
Read PDF<h4>Motivation</h4>DNA-encoded library (DEL) technology has been developed as a powerful platform for drug development. Live cell-based selection methodologies were recently developed to expedite drug candidate discovery with higher biological relevance. Nevertheless, hit characterization is challenged …
Read PDFBACKGROUND: Remote homology detection is critical for inferring evolutionary and functional relationships among proteins, but divergence below 30% identity often hinders standard sequence-based searches. Profile-based methods and HMMs improve sensitivity, yet many distant homologues remain …
Read PDFBACKGROUND: Guillain-Barré syndrome (GBS) is a acute immune-mediated peripheral neuropathy with scarce incidence, yet its molecular mechanisms remain incompletely elucidated. This study aims to systematically identify key hub genes and signaling pathways in GBS to …
Read PDFOral Squamous Cell Carcinoma (OSCC) is one of the most occurred cancer types with yearly 377,713 cases and 177,000 deaths. Traditional risk factors of OSCC include smoking, alcohol consumption, excessive sun exposure, family history of …
Read PDFDigital health (DH) has emerged as the dominant terminology for technology-enabled healthcare, reshaping institutional discourse, educational programmes and policy agendas. DH is often portrayed as a novel discipline that could supersede Biomedical and Health Informatics …
Read PDFLung cancer poses a marked threat to global health, with lung adenocarcinoma (LUAD) being a predominant subtype. Despite their availability, treatment options often fall short of expectations. In this context, Traditional Chinese Medicine, known for …
Read PDF<h4>Objective</h4><i>Mycobacterium leprae</i> causes leprosy, an infectious disease that has persisted over centuries and is still an issue in public health in many nations. Diverse bioinformatics techniques have been effectively employed to annotate the functions of …
Read PDF<h4>Motivation</h4>Prediction of Compound-Protein Interactions (CPI) in bacteria is crucial to advance various pharmaceutical and chemical engineering fields, including biocatalysis, drug discovery, and industrial processing. However, current CPI models cannot be applied for bacterial CPI prediction …
Read PDF<h4>Purpose</h4>Accumulating evidence implicates macrophage polarization in the pathogenesis of epilepsy. This study integrated bioinformatics and experimental approaches to identify macrophage polarization-related genes (MPRGs) as potential biomarkers and to elucidate their putative causal roles and immune …
Read PDF<h4>Summary</h4>Rapid development of genomic technologies in recent years enables personalised medicine to become an essential part of healthcare. Advanced computational methods are required to extract relevant insights that can be applied in clinical settings. This …
Read PDFThis review explores the role of bioinformatics in identifying novel biomarkers for immune cell exhaustion (ICE), a dysfunction state in T cells during chronic infections and cancer. ICE, marked by upregulation of inhibitory receptors such …
Read PDFAccording to FlyBase, the <i>Drosophila melanogaster</i> (fruit fly) <i>Neprilysin-like 15 (Nepl15)</i> gene has only one annotated transcript and a 686-amino acid-long protein. However, <i>Nepl15</i> transcripts exhibit organ- and sex-specific differential expression, and <i>Nepl15</i> knock-out mutation …
Read PDFtRNA-derived small RNAs (tsRNAs) are a class of noncoding RNAs (ncRNAs) generated via the site-specific enzymatic cleavage of mature or precursor tRNAs. They are ubiquitously expressed across diverse species and are detectable in numerous cell …
Read PDFCognitive effects of breast cancer antiestrogen endocrine therapy are a salient concern for survivors, given the growing evidence that estrogen plays a role in late-life dementia risk. The APOE4 genotype has been linked with risk …
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