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<h4>Motivation</h4>Millions of high-throughput, molecular datasets have been shared in public repositories. Researchers can reuse such data to validate their own findings and explore novel questions. A frequent goal is to find multiple datasets that address …
Read PDF<h4>Motivation</h4>We introduce Empirical Genotype Generalizer for Samples (EGGS) which accepts empirical genotypes with missing data and replicates the distribution of missing genotypes along the empirical segment in other replicates. The empirical segment must have a …
Read PDF[This corrects the article DOI: 10.1371/journal.pone.0315582.].
Read PDFSteroid-induced osteonecrosis of the femoral head (SONFH) is a debilitating disease caused by glucocorticoid abuse, characterized by complex pathogenesis and unclear molecular mechanisms. Dysfunction of bone marrow mesenchymal stem cells (BMSCs) and their exosome-mediated signalling …
Read PDFThe rise of digital health (DH) has sparked debates about its relationship with the long-established field of biomedical and health informatics (BMHI), with some questioning the need for new academic programmes in DH since much …
Read PDFAtrial fibrillation (AF) is a common arrhythmia associated with immune dysregulation and complex molecular mechanisms. This observational bioinformatics study aimed to identify key genes involved in AF, explore their functional roles, and uncover potential therapeutic …
Read PDFThis study aimed to identify pyroptosis-related hub genes and investigate immune cell infiltration in IgA nephropathy (IgAN) using bioinformatics and experimental validation. Gene expression data from the GEO database (GSE93798) were analyzed, and differential expression …
Read PDF<h4>Motivation</h4>There are many diseases with established genetic factors, such as Huntington's disease (HD), that are characterized by variable rates of progression. However, beyond the contribution of the known genetic factors - in this case the …
Read PDFThis dataset arises from a multilingual survey of AI use among participants and community members in the DBCLS BioHackathon 2025 in Japan. The questionnaire, offered in English, Japanese, and Thai, asked about how often respondents …
Read PDF<h4>Summary</h4>We report the second version of the R package "seraphim", a toolbox developed to process and analyze the output of spatially explicit phylogeographic reconstructions. This approach - also known as continuous phylogeographic inference - is …
Read PDFObesity is a multifactorial disease associated with a chronic imbalance between energy intake and energy consumption, as well as the ingestion of high-fat foods. It is widely reported that the Mediterranean Diet (MD), a dietary …
Read PDFAortic dissection (AD) is a vascular surgical disease that seriously threatens human health. Due to a high misdiagnosis rate and unclear pathogenesis, it brings greater challenges to AD patients and vascular surgeons. This study aimed …
Read PDFThe Protein Data Bank (PDB) archives 3D structures of macromolecules determined experimentally using various methods. It is jointly managed by the Worldwide Protein Data Bank (wwPDB) consortium. Research Collaboratory for Structural Bioinformatics (RCSB) PDB, the …
Read PDF<h4>Motivation</h4>Predicting synergistic cancer drug combinations through computational methods offers a scalable approach to creating therapies that are more effective and less toxic. However, most algorithms focus solely on synergy without considering toxicity when selecting optimal …
Read PDFThe integration of multi-omics data has become increasingly important in advancing precision medicine and systems biology. However, the reliability and trustworthiness of artificial intelligence (AI) models applied to such data remain critical concerns. This review …
Read PDF<h4>Motivation</h4>Forensic genetic genealogy (FGG) requires building and interpreting complex family trees that integrate genetic, genealogical, and contextual metadata to associate unknown donors of forensic evidence with reference samples of potential relatives. Existing genealogy platforms are …
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