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<h4>Motivation</h4>Understanding the role of transcription factors (TFs) in plants is essential for the study of gene regulation and various biological processes. However, both TF detection and classification remain challenging due to the great diversity and …
Read PDFHere, we present quickARSC, a command-line tool computing elemental composition per amino acid residue side chain (ARSC) from amino acid sequences. We also provide the web interface to enable users to access, filter, visualize, and …
Read PDF<h4>Summary</h4>Accurately predicting protein-ligand interactions and binding affinities is essential for advancing structural biology. Despite recent advancements in deep learning, achieving rapid and precise predictions remains a challenging task. Our approach, Protein-Ligand Cross-Modal Fusion Predictor (PLXFPred), …
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Read PDFThe subcellular localization of mRNAs determines the spatial context of protein translation and plays a critical role in the precise regulation of protein function. However, existing computational approaches for predicting eukaryotic mRNA localization are often …
Read PDFDysregulation of signaling pathways contributes substantially to the initiation and progression of laryngeal squamous cell carcinoma (LSCC). This study aimed to elucidate the mTOR and S6 kinase (S6K) gene expression levels, clinical significance, interplay of …
Read PDF<h4>Motivation</h4>Cyclic immunofluorescence (IF) techniques enable deep phenotyping of cells and help quantify tissue organization at high resolution. Due to its high dimensionality, workflows typically rely on unsupervised clustering, followed by cell type annotation at a …
Read PDFFollowing the submission of application GMFF-2023-21236 under Regulation (EC) No 1829/2003 from Bayer CropScience LP, the Panel on Genetically Modified Organisms of the European Food Safety Authority was asked to deliver a scientific risk assessment …
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Read PDF<h4>Motivation</h4>High-throughput multi-omics technologies produce increasingly large and heterogeneous datasets that are difficult to analyze without advanced computational expertise. Existing bioinformatics tools are often fragmented or limited to specific omics types, hindering reproducibility and accessibility. There …
Read PDF<h4>Summary</h4>Marker assisted breeding (MAB) supports breeding by identifying individuals or molecular markers associated with important traits. MAB methods include genome-wide association studies (GWAS) and genomic selection (GS). Local haplotypes are regions of DNA that are …
Read PDF<h4>Background</h4>Ovarian cancer exhibits the highest mortality rate among gynecologic malignancies. Platinum resistance remains a key determinant of poor clinical outcomes. Early prediction of platinum resistance is critical for personalized treatment. This study aimed to identify …
Read PDF[This corrects the article DOI: 10.3389/fbinf.2025.1599098.].
Read PDFThe fungus <i>Rhizomucor pusillus</i> CBS 143028 is the source of a novel food called Fermotein®, a whole fungal biomass rich in proteins, fibres, and micronutrients. To enable Fermotein® to enter the food market, the safety …
Read PDFTracking object instances, such as individual living cells or molecular accumulations, and their behavior is a common challenge in 2D and 3D volumetric biomedical imaging. Combined with dynamic environments caused by unintentional camera misalignment over …
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