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<h4>Motivation</h4>Genome-wide association studies (GWAS) at biobank scale are computationally intensive, especially for admixed populations requiring robust statistical models. SAIGE is a widely used method for generalized linear mixed-model GWAS but is limited by its CPU-based …
Read PDF<h4>Background</h4>Benzo[a]pyrene (BaP) is a recognized mutagen and carcinogen, yet epidemiological links to breast cancer (BC) remain inconclusive.<h4>Methods</h4>We integrated network toxicology, machine learning, and bioinformatics. BaP targets (ChEMBL, PharmMapper, SEA, GeneCards, OMIM) were intersected with BC …
Read PDF<h4>Background</h4>MiR-224-5p has been proven to play an important role in regulating cell differentiation. This study aimed to clarify the regulatory role and mechanism of miR-224-5p in the osteogenic differentiation of human dental pulp stem cells …
Read PDF<h4>Introduction</h4>Systemic cervical cancer management continues to be challenging. Numerous chemotherapies have been approved, but predicting response is difficult due to the lack of biomarkers. Here, we analyze the genetic and protein profiles of 20 cervical …
Read PDF[This corrects the article DOI: 10.1097/TXD.0000000000001829.].
Read PDFThe European Molecular Biology Laboratory's European Bioinformatics Institute (EMBL-EBI) is one of the world's leading sources of public biomolecular data. Based at the Wellcome Genome Campus in Hinxton, UK, EMBL-EBI is one of six sites …
Read PDF<h4>Summary</h4>Fluorosequencing generates millions of single peptide reads, yet a principled route to quantitative protein abundances has been lacking. We present a probabilistic framework that adapts expectation-maximization (EM) to the fluorosequencing measurement process, using posterior peptide …
Read PDF<h4>Background</h4>Targeted drugs are medications designed to treat diseases by targeting specific sites on cancerous or diseased cells. Multi-target drugs can target multiple protein sites to treat diseases, improving therapeutic efficiency, but are more challenging to …
Read PDFINTRODUCTION: Cervical cancer is the fourth most common cancer in women and remains a major global health issue. Long non-coding RNAs (lncRNAs) play a crucial role in tumor biology regulation. This study investigates the role …
Read PDF<h4>Background</h4>Cholangiocarcinoma (CCA) is a highly heterogeneous biliary malignancy with a poor prognosis. Finding early diagnosis and therapeutic targets for CCA is of great importance. The aim of this study was to screen for key genes …
Read PDF<h4>Motivation</h4>Predicting immunoglobulin-antigen (Ig-Ag) binding remains a significant challenge due to the paucity of experimentally resolved complexes and the limited accuracy of de novo Ig structure prediction.<h4>Results</h4>We introduce IgPose, a generalizable framework for Ig-Ag pose identification …
Read PDF<h4>Summary</h4>Mixtum is a Python-based code that estimates ancestry contributions in a process of two-way admixture based on bi-allelic genotype data. The outcomes of Mixtum come from the geometric interpretation of the f-statistics formalism. Designed with …
Read PDFBACKGROUND: Indole-3-acetic acid (IAA) is a crucial plant hormone for growth and development. Among bacteria capable of IAA synthesis, tryptophan-dependent pathways are the primary pathway for IAA production. Identifying IAA-producing bacteria is essential for understanding …
Read PDFModern poultry breeding requires integrated genomic and phenotypic data to optimize production traits, yet comprehensive resources remain fragmented and often inaccessible. We developed a comprehensive electronic Genome-Wide Association Studies (GWAS) Atlas for chicken breeds that …
Read PDFThe increasing research confirms the function of microRNAs (miRNAs) play a vital role in the diagnosis, treatment, and prognosis of diseases. Screening the potential candidate miRNAs related to the diseases by the computational methods may …
Read PDFThe samples were under the influence of the treatment with pyrrolizine. Salinity adversely impacts oilseed production by leading to excessive salt accumulation and degrading soil structure. In rapeseed, salinity specifically hinders germination and the growth …
Read PDF<h4>Background</h4>Endometriosis is a complex gynecological disorder lacking reliable biomarkers. This study aimed to identify core diagnostic genes through integrated computational approaches. Multiple endometriosis transcriptomic datasets were analyzed.<h4>Methods</h4>Differential expression analysis and Weighted Gene Co-expression Network Analysis …
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