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<h4>Motivation</h4>Knowledge graphs and structural causal models have each proven valuable for organizing biomedical knowledge and estimating causal effects, but remain largely disconnected: knowledge graphs encode qualitative relationships focusing on facts and deductive reasoning without formal …
Read PDFBACKGROUND: Nasopharyngeal carcinoma (NPC) continues to represent a significant therapeutic challenge. Despite the substantial success of radiotherapy, chemotherapy, and immunotherapy, their effectiveness remains limited in recurrent or advanced NPC. Hence, the urgent identification of new …
Read PDF<h4>Objective</h4>This study aimed to identify key molecular signatures and therapeutic targets in early sepsis through integrated bioinformatics analysis.<h4>Methods</h4>We analyzed three independent blood transcriptomic datasets (GSE95233, GSE137340, GSE57065) from the Gene Expression Omnibus. Differential expression, functional …
Read PDF<h4>Background</h4>Prostatic hyperplasia is a common condition among aging males characterized by excessive prostate cell proliferation, and while it is a benign process, it involves significant metabolic reprogramming and immune infiltration-features typically associated with malignant tumors. …
Read PDF<h4>Motivation</h4>Accurate in silico identification of B-cell epitope residues is crucial for antibody design and structure-guided vaccine development. Although recent protein language models and structure-aware methods can capture spatial information of tertiary structure when generating residue …
Read PDF<h4>Objective</h4>This study investigates the role and underlying mechanism of FABP4 in RA secondary OP by examining its correlation with the condition.<h4>Methods</h4>DEGs related to RA and OP were identified using GEO datasets (GSE17755 and GSE230665), focusing …
Read PDFPrompt and accurate identification of Listeria monocytogenes at the whole-genome level is essential for food safety surveillance and outbreak prevention, yet existing culture-based, PCR, and next-generation sequencing (NGS) workflows are either slow, labor-intensive, or rely …
Read PDFData Science can revolutionize biomedical sciences, and ultimately, health. However, this relies on core elements, including computing infrastructure, data science skills, and well-curated contextually relevant data, which are limited in low- and middle-income countries. Many …
Read PDF<h4>Motivation</h4>Single-cell technologies enable high-resolution cellular studies but face challenges in identifying differential features due to data complexity.<h4>Results</h4>We present OTMODE, a non-parametric method using unbalanced Sinkhorn algorithm and Wald test to improve differential feature identification in …
Read PDF<h4>Objective</h4>This investigation reports on a Shwachman-Diamond syndrome (SDS) case arising from compound heterozygous genetic variations affecting the EFL1 locus. A systematic review of published literature was undertaken to compile data on clinical manifestations, management strategies, …
Read PDFHuman leukocyte antigen (HLA) molecules play a pivotal role in antigen presentation. Tumor cells present neoantigens on the cell surface via HLA molecules, thereby activating cytotoxic T cells and eliciting immune responses. This process offers …
Read PDFTo investigate the role of small ubiquitin-like modification (SUMO) in Alzheimer's disease (AD) and its pathogenesis, this study employed bioinformatics methods to identify diagnostic biomarkers for AD based on SUMO-related genes (SRGs). It further conducted …
Read PDFFerroptosis, an iron‑dependent form of regulated cell death driven by lipid peroxidation, has emerged as a key mechanism underlying tissue degeneration and impaired regeneration in musculoskeletal disorders. Although ferroptosis is associated with conditions such as …
Read PDF<h4>Purpose</h4>To investigate trends in surgical experience performing pelvic and paraaortic lymphadenectomies by gynecologic oncology (GO) fellows in the U.S.<h4>Methods</h4>Summary statistics for ACGME GO training programs were obtained from the ACGME public reporting system. The ACGME …
Read PDF<h4>Objective</h4>Myocardial infarction leads to heart failure greatly increasing the risk of adverse cardiovascular events. Empagliflozin (EMPA), a sodium-dependent glucose transporters 2 (SGLT2) inhibitor, has been demonstrated to provide effective cardiovascular protection, while the underlying metabolic …
Read PDFBACKGROUND: Organoid image segmentation is essential for quantitative analysis in disease modeling and drug screening, yet remains highly challenging due to substantial morphological variability and blurred boundaries in organoid images. Existing approaches often struggle to …
Read PDF<h4>Objective</h4>To investigate the effects of exercise on bone marrow stem cells (BMSCs) and determine underlying molecular network mechanisms through bioinformatics analysis combined experimental validation.<h4>Methods</h4>Target genes related to exercise and BMSCs were retrieved from the Gene …
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