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BACKGROUND: Predicting the binding affinity between drugs and proteins is crucial for accelerating drug discovery. However, traditional research methods typically treat binding site detection and affinity prediction as two separate tasks, lacking solutions that integrate …
Read PDFThis study aimed to identify tumor-associated autoantibodies (TAAbs) with diagnostic potential for the early detection of oral squamous cell carcinoma (OSCC). Bioinformatics analyses were used to screen candidate genes. The candidate tumor-associated antigens (TAAs) were …
Read PDFBreast carcinoma ranks among the most prevalent malignant tumors affecting women worldwide. The discovery of biomarkers is important in the diagnosis of breast cancer and the prediction of clinical outcomes in afflicted patients. Heterogeneous nuclear …
Read PDF<h4>Background</h4>An increasing number of studies have shown that ferroptosis is related to the initiation and development of small cell lung cancer (SCLC). The systematic review aimed to summarize the characteristics of ferroptosis from its pathogenetic …
Read PDF<h4>Motivation</h4>Antibiotic resistance is predicted to become the leading cause of human mortality by 2050. Despite this, no other major antibiotic class has been approved for medical use since 1987. Nevertheless, phage tail proteins offer a …
Read PDF<h4>Motivation</h4>Sequence motif identification is crucial for understanding molecular recognition, particularly in immune responses involving peptide binding to major histocompatibility complex (MHC) Class I molecules for antigen presentation to T cells. Traditionally, MHC Class I binding …
Read PDF<h4>Introduction</h4>Obesity and non-alcoholic fatty liver disease (NAFLD) are known to be closely interlinked; however, the mechanism of their interaction is unclear. This study sought to explore the causal relationship and shared biomarkers in obesity and …
Read PDFWe present CBR-db, a database with detailed chemical properties data for biochemical compounds and reactions. We provide the first chemically consistent analyses and detailed chemical property data for a biologically relevant set of 148,673 reactions …
Read PDF<h4>Background</h4>Infected bone defects are difficult to treat due to bacterial biofilms and chronic inflammation. Systemic antibiotics often fail and cause severe side effects. A dual-drug delivery system that combines antibacterial and osteo-immunomodulatory actions may offer …
Read PDFBreast cancer is a prevalent malignancy among women worldwide. Understanding its molecular mechanisms is crucial for prevention, early diagnosis, and treatment. Using a dataset of intraoperative radiotherapy (IORT) for breast cancer, we analyzed 21 breast …
Read PDFBACKGROUND: Small nucleolar RNAs (snoRNAs) are increasingly recognized for their involvement in human diseases. Accurate and robust prediction of disease-associated snoRNAs is crucial for accelerating drug discovery and disease treatment. However, the limited availability of …
Read PDFParkinson's disease (PD) is a complex neurodegenerative disorder for which current treatments are often symptomatic and lack disease-modifying effects. The traditional Chinese medicine herb pair Tianma-Gouteng, composed of <i>Gastrodia elata</i> Bl (Tianma) and <i>Uncaria rhynchophylla</i>(Miq.) …
Read PDF<h4>Background</h4>The incidence of papillary thyroid cancer (PTC) has risen sharply over the past several decades. Early identification of high-risk PTC is crucial to mitigate the societal burden associated with its overdiagnosis. ER-phagy, a selective form …
Read PDF<h4>Background</h4>Regulated cell death (RCD) maintains cellular homeostasis and tissue integrity, playing a pivotal role in both health and disease. A variety of RCD subroutines have been identified, each characterized by distinct molecular and morphological features. …
Read PDFThe present study aims to identify key genes and elucidate the molecular mechanisms underlying osteonecrosis of the femoral head (ONFH), with the goal of discovering effective diagnostic and therapeutic targets. Microarray data were sourced from …
Read PDFThe rise of mRNA vaccines highlights the pivotal role of T-cell antigen identification in modern vaccinology and personalized medicine. T-cell recognition relies on the sophisticated ternary interaction between the T-cell receptor (TCR), the major histocompatibility …
Read PDFBACKGROUND: Diabetic nephropathy (DN) has been pathophysiologically associated with macrophage activity; however, the molecular mechanisms underlying this relationship remain unclear. This study aimed to explore the regulatory mechanisms linking DN and macrophages using integrated bioinformatics …
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Read PDF<h4>Ethnopharmacological relevance</h4><i>Fritillariae Cirrhosae Bulbus</i> is a traditional herb with diverse activities, yet its active metabolites against type 2 diabetes (T2D) remain unclear.<h4>Objective</h4>This study aimed to identify key bioactive metabolites from <i>Fritillariae Cirrhosae Bulbus</i> through database …
Read PDF<h4>Background</h4>Lumbrokinase is a novel antithrombotic drug isolated and purified from earthworms and used in the treatment of stroke and cardiovascular disease. However, to date, there has been no systematic classification of lumbrokinase genes.<h4>Methods</h4>In this study, …
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