Search the literature by keyword, topic, or author. Filter to articles with full text available.
3689 results
The escalating global threat of multidrug-resistant (MDR) <i>Pseudomonas aeruginosa</i>, designated by the WHO as a critical-priority pathogen, necessitates urgent development of alternative therapeutics. We present <i>Pseudomonas</i> phage Arefeen1, isolated from Bangladeshi wastewater, as a clinically …
Read PDF[This corrects the article DOI: 10.1016/j.ekir.2025.06.017.].
Read PDF<h4>Purpose</h4>HER2DX is a validated genomic assay used to support treatment decisions in early-stage HER2-positive (HER2+) breast cancer. It provides three scores: relapse risk, likelihood of pathologic complete response (pCR), and ERBB2 mRNA expression. This study …
Read PDF<h4>Motivation</h4>The world of agriculture is rapidly changing with advances in artificial intelligence and demands for greater feed and food security considering environmental and sustainability challenges. The 30th Conference on Intelligent Systems in Molecular Biology (ISMB) …
Read PDFPolycystic ovary syndrome (PCOS) is one of the most prevalent and heterogeneous disorders in reproductive endocrinology, contributing to substantial reproductive, metabolic, and psychological morbidity. Despite major advances in genomics, neuroendocrinology, and systems biology, translation into …
Read PDFPharmacogenomic (PGx) information has the potential to support the safe and effective use of medicines, yet there is uncertainty about how this information can be best communicated to patients. Summaries of product characteristics (SmPCs) and …
Read PDF<h4>Background</h4>Gaucher disease exhibits substantial genetic heterogeneity across populations. Asian populations remain understudied despite representing diverse genetic backgrounds. The systematic review was conducted to identify GBA1 mutations and genotype-phenotype correlations in Asian populations.<h4>Methods</h4>Following PRISMA guidelines, three …
Read PDFPlasmodium vivax is a major cause of malaria globally and has recently been transmitted locally in the USA. P. vivax produces homologs of host proteins, including cytokines such as macrophage migration inhibitory factor (MIF). MIF …
Read PDFAcute myeloid leukemia (AML) is a heterogeneous hematological malignancy characterized by extensive genomic alterations and molecular diversity, posing significant therapeutic challenges. Current treatment strategies lack precise predictive biomarkers for chemotherapy response, highlighting the need for …
Read PDFVascular malformations of the head and neck carry high morbidity because of their proximity to the airway, cranial nerves, sensory organs, and cerebral vasculature. Although the ISSVA classification of vascular anomalies has standardized diagnostic terminology, …
Read PDF<h4>Background</h4>D²EFT (Dolutegravir and Darunavir Evaluation in Adults Failing Therapy) was a phase 3b/4 randomized clinical trial designed to assess second-line treatment options systematically. This substudy evaluated the distribution of drug resistance mutations (DRMs) before treatment …
Read PDFBACKGROUND: Endometriosis (EMs) is a prevalent gynecologic disorder that often causes severe chronic pelvic pain and infertility. Although genome-wide association studies have identified common variants of EMs, the contribution of rare variants remains unclear. RESULTS: …
Read PDFArchaic introgression has shaped the modern human immune system, particularly components involved in RNA virus responses. In contrast, its contribution to DNA virus defense remains poorly understood. Here, we investigate the contribution of Neandertal- and …
Read PDFBACKGROUND: Wild emmer wheat (Triticum turgidum subsp. dicoccoides, WEW) was one of the first crops domesticated in the Neolithic revolution that shifted humanity to agrarian societies. Understanding its population genomics has both evolutionary significance and …
Read PDF<i>Calanthe aristulifera</i> is a critically endangered orchid species of profound horticultural and ecological significance. However, establishing its species integrity is complicated by frequent natural introgression with sympatric relatives, such as <i>C. sieboldii</i> and <i>C. discolor</i>. …
Read PDFBACKGROUND: The Fagaceae family includes key forestry species in temperate and Mediterranean ecosystems, many of which are increasingly impacted by drought stress and high temperatures, exacerbated by climate change. HSP90 proteins play a crucial role …
Read PDFNo abstract available.
Read PDF