Editorial for the Special Issue “Genomics of Extremophiles and Archaea”
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Complete genome and functional insights into Microbacterium sp. strain FBCC-B4120, a novel freshwater isolate with diverse biotechnological traits
The genus Microbacterium encompasses a diverse group of Actinobacteria with broad ecological distribution and functional versatility. Here, we report the complete genome sequence of Microbacterium sp. FBCC-B4120, a novel strain isolated from a freshwater ecosystem …
Read PDFEquitable inclusion of racialised communities in genomic research: a scoping review
<h4>Objectives</h4>Genome Canada has committed significant resources to ensure that racialised groups are included in its initiatives; however, specific equity considerations related to engaging these communities in human genomic research continue to require deeper attention and …
Read PDFThe yeast genome at 30: a blueprint written by a collaborative and consilient community
Completion of the Saccharomyces cerevisiae genome sequence three decades ago marked a defining moment in eukaryotic genomics. Beyond a technical milestone, it established a shared reference that transformed how yeast biology is studied, interpreted, and …
Read PDFRelational work in implementation: a qualitative analysis of intra- and inter- professional strategies leveraged in genomic multidisciplinary teams
<h4>Background</h4>Relationships are foundational to successful implementation of innovations in healthcare. In genomic medicine, multidisciplinary teams with good communication are most effective to provide safe genomic care; however, working together could be challenging due to the …
Read PDFA novel m7G RNA methylation-related signature associated with MAPK signaling pathways in acute ischemic stroke
<h4>Objectives</h4>Ischemic stroke represents a major global cause of disability and death. Timely recanalization of occluded vessels to salvage the ischemic penumbra is the cornerstone of acute ischemic stroke (AIS) treatment. Nevertheless, the molecular mechanisms driving …
Read PDFA Cross-Tissue Multiomics Analysis Reveals the Protective Role of TGFBR3 in Postmenopausal Osteoporosis
<h4>Background</h4>Postmenopausal osteoporosis (PMO) develops as a result of pathological cross-tissue interactions. However, current experimental paradigms are constrained by their single-tissue focus, hindering efforts to discover systemwide regulatory genes.<h4>Objective</h4>We aimed to discover conserved genetic regulators of …
Read PDFIGD: a multi-omics database for Ipomoea pes-caprae genomic and biological research
Ipomoea pes-caprae (IPC) is a perennial halophytic vine with remarkable salt and drought tolerance, playing a critical ecological and medicinal role in tropical and subtropical coastal ecosystems. Despite the availability of a high-quality chromosome-level reference …
Read PDFIdentification and validation of stable reference genes via transcriptome analysis for studying sex differentiation in tung tree (Vernicia fordii)
Tung oil, obtained from the seeds of the tung tree (Vernicia fordii), holds significant economic value. Nevertheless, the low proportion of female flowers in tung trees limits tung oil yield. Studying the expression of genes …
Read PDFACMG Medical Directors' Special Interest Group survey: Current challenges for medical genetics clinics
<h4>Purpose</h4>The American College of Medical Genetics and Genomics Medical Directors' Special Interest Group (SIG) began in 2021 as a forum for directors of medical genetics clinical groups to share questions, concerns, current practices, and solutions …
Read PDFPrenatal diagnosis and clinical evaluation of fetuses with structural X chromosome abnormalities: a ten-year single-center retrospective study
BACKGROUND: Structural X chromosome abnormalities are rare conditions and pose great challenges in prenatal genetic counseling. The present study aimed to identify and investigate the pregnancy outcome of fetuses with X chromosome structural abnormalities in …
Read PDFEffects of apolipoprotein E and solute carrier organic anion transporter family member 1B1 gene polymorphisms on statin efficacy and safety in dyslipidemic patients
<h4>Objective</h4>To investigate the distribution of the apolipoprotein E ( ApoE ) and solute carrier organic anion transporter family member 1B1 ( SLCO1B1 ) polymorphisms in dyslipidemia patients and their impact on statin efficacy and safety.<h4>Methods</h4>A …
Read PDFThe association of periodontitis with telomere length: a meta-analysis
BACKGROUND: Telomere length (TL) is a biomarker of biological aging and has been linked to various health outcomes; however, its relationship with periodontitis remains inconsistent. This meta-analysis aimed to evaluate the association between periodontitis and …
Read PDFDesigning inclusive newborn sequencing research: insights from parents in underrepresented communities
<h4>Background</h4>It is essential that studies of genomic sequencing (GS) in newborns and children include individuals from under-represented racial and ethnic groups (URG) to ensure future applications are equitably implemented. We conducted interviews with parents from …
Read PDFNon-Canonical, Somatic-Dependent Vertical Transmission of Wolbachia in an Aphid
Wolbachia, a widespread endosymbiotic bacterium that infects a broad range of arthropods and nematodes, relies on vertical transmission from mother to offspring. This process often involves colonisation of the host germline, subsequent transfer to developing …
Read PDFThree-dimensional phenotyping: Technological advances and applications in genomics-assisted crop breeding
With rapid advancements in breeding technologies, phenomics, and artificial intelligence, crop breeding is progressively entering an era of greater precision and efficiency. In this context, three-dimensional (3D) phenotyping techniques-leveraging multidimensional spatial resolution capabilities-have overcome the …
Read PDFA Novel Neurofibromatosis Type 1 (NF1) Frameshift Mutation Associated With Atypical Hypotensive Pheochromocytoma: A Case Report
Neurofibromatosis type 1 (NF1) is an autosomal dominant tumor predisposition syndrome associated with an increased risk of pheochromocytoma. Pheochromocytoma typically presents with hypertension and catecholamine excess; however, atypical clinical features may occur. A 58-year-old Turkish …
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