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<h4>Background</h4>Understanding how overweight and obesity impact quality of life, psychological well-being, and social functioning is essential for informing and optimizing patient-centric disease management strategies.<h4>Aims</h4>This study aims to investigate the humanistic burden of excess body weight …
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Read PDFFuchs' endothelial corneal dystrophy (FECD) is a progressive eye disease characterized by accelerated loss of endothelial cells and the development of focal excrescence (guttae) on Descemet's membrane, resulting in cornea opacity and vision deterioration. The …
Read PDFIschemic stroke (IS) remains a leading cause of death and disability, with limited effective treatments in the acute phase. Mitophagy, the selective degradation of damaged mitochondria, plays a crucial role in cellular homeostasis and survival …
Read PDFThe cerebellar rhombic lip neurogenic niche is critical for glutamatergic neurogenesis, and dysregulated differentiation of rhombic lip lineage cells is hypothesized to cause medulloblastoma (MB), a malignant pediatric cancer lacking targeted therapies. Humans have structural …
Read PDFProteins that impact phenotype and disease are often approximated by RNA expression, which poorly infers protein abundance. We developed DeepGxP, a deep-learning model trained on The Cancer Genome Atlas pan-cancer data, to predict protein abundance …
Read PDFRecent years have seen a rise of single-cell proteomics by data-independent acquisition mass spectrometry (DIA MS). While diverse data analysis strategies have been reported in literature, their impact on the outcome of single-cell proteomic experiments …
Read PDFTraditional bulk RNA sequencing often masks cell-to-cell variability, leading to a loss of individual heterogeneity information. Single-cell RNA sequencing (scRNA-seq) preserves cellular heterogeneity by reverse-transcribing, amplifying, as well as sequencing mRNA molecules from individual cells, …
Read PDFPeriodontitis is one of the most common oral inflammatory diseases. Baiyaojian decoction, known for its prominent immunomodulatory and anti-inflammatory properties, shows significant potential in treating periodontitis, though its molecular mechanisms remain unknown. The active ingredients …
Read PDFAccurately annotating cell types is essential for extracting biological insight from single-cell RNA sequencing data. Although cell types are naturally organized into hierarchical ontologies, most computational models do not explicitly incorporate this structure into their …
Read PDF<h4>Background</h4>Atherosclerosis (AS) is a widespread cardiovascular disorder that constitutes a major contributor to global morbidity and mortality, thereby imposing significant economic burdens on healthcare systems worldwide. Efferocytosis, the phagocytic removal of apoptotic cells, serves as …
Read PDF<h4>Background</h4>Osteosarcoma (OS) is an aggressive bone malignancy with a poor prognosis. Dysregulated calcium homeostasis may contribute to OS progression.<h4>Methods</h4>Various machine learning algorithms were integrated into multiple model combinations to identify key prognostic genes. Single-cell expression …
Read PDF<h4>Background</h4>Electrophysiological features of glioblastoma cells (GBCs) remain largely elusive, challenging our comprehension of glioblastoma pathophysiology. Spiking GABAergic-oligodendrocyte-progenitor (OPC) tumor cells were recently described in IDH-mutant glioma, correlating with prolonged patient survival. Here, we characterize single-cell …
Read PDFOmics research is changing the way medicine develops new strategies for diagnosis, prevention, and treatment. With the surge of advanced machine learning models tailored for omicss analysis, recent research has shown improved results and pushed …
Read PDF<h4>Background</h4>Cirrhosis is a severe liver disease characterized by inflammation, fibrosis, and immune dysregulation. This study exploits publicly available single-cell sequencing datasets to decipher disease-relevant specific immune cell subtypes, their gene expression profiles and altered transcription …
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