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Immunotherapy has seen success in treating patients with cancer, but variable responses underscore the need for effective patient stratification and therapy planning. Computational tools integrating multi-omics, imaging and machine learning have advanced, yet reliable personalized …
Read PDFDiabetic kidney disease (DKD) lacks specific biomarkers reflecting the interplay between mitochondrial dysfunction and immune microenvironment remodeling. To address this, we integrated multi-dataset transcriptomics (GEO, MitoCarta 3.0, GeneCards) with Weighted Gene Co-expression Network Analysis, protein-protein …
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Read PDFSkeletal muscle has the impressive capacity to completely regenerate even after relatively severe injuries in young individuals, but this process is dysregulated in multiple cell types in the microenvironment in numerous diseases and aging. In …
Read PDFSepsis is a major cause of global neonatal mortality, affecting 1.3 to 1.9 million neonates worldwide. Accurate diagnoses and effective treatment of sepsis during the onset is essential to improve outcomes. Current efforts to develop …
Read PDFStem cell-derived organoids hold promise to model tissue-specific diseases. To enable this, it is crucial to assess how transcriptional signatures, cellular organization, and composition of organoids compare to <i>in vivo</i> counterparts. However, spatial transcriptomics has …
Read PDF<h4>Background</h4>Inter-organ communication within the cardio-cerebral-renal axis orchestrates systemic homeostasis and disease progression. However, conventional methods fail to capture its spatiotemporal complexity; consequently, this creates evidence gaps in dynamic network dissection. Therefore, spatial multi-omics and organ-on-a-chip …
Read PDFSpatially resolved transcriptomics (SRT) is a promising new technology that enables simultaneous analysis of gene expression and spatial information for biomedical research. However, the existing statistical and deep learning algorithms used for analyzing SRT data …
Read PDFMonoterpene indole alkaloids encompass a diverse class of plant natural products. Many of these valuable compounds, including the anticancer medicines vinblastine and vincristine (<i>Catharanthus roseus</i>) and the antiaddiction treatment ibogaine (<i>Tabernanthe iboga</i>) utilize a common …
Read PDFSpatial transcriptomics (ST) measures gene expression at a set of spatial locations in a tissue. Communities of nearby cells that express similar genes form spatial domains. Specialized clustering algorithms have been developed to identify spatial …
Read PDFSquamous cell carcinomas (SCCs) originate in epithelial tissues of older individuals who have been exposed to environmental carcinogens. Despite overlapping clinical hallmarks, SCCs from different anatomic sites have different prognoses. Here we show that fibroblasts …
Read PDFIn this editorial, we provide an integrative overview of MiniResource papers published in Molecules and Cells in 2024 and 2025, which establish reliable methodological practices across various fields in molecular and cellular biology. By emphasizing …
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