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3689 results

Full text 2025

Integrative analysis of RNA expression signatures and recurrent genomic alterations before treatment: link to menopausal status, short-term endocrine therapy response and disease-free survival in luminal breast cancer

Zhang G, Ni H, Mishieva L, et al.

<h4>Background</h4>Endocrine therapy with tamoxifen (TAM) or aromatase inhibitors (AI) is an effective treatment of patients with estrogen receptor-positive, HER2-negative luminal breast cancer. However, many patients do not respond to this therapy, leading to disease recurrence. …

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Bioinformatics
Full text 2025

Accelerated growth increases the somatic epimutation rate in trees

Zhou M, Schmied G, Vo BT, et al.

Trees are integral to ecosystems and hold considerable economic importance. Their exceptional longevity and modular structure also make them valuable models for studying the long-term accumulation of somatic mutations and epimutations in plants. Empirical evidence …

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Bioinformatics
Full text 2026

Genetics of growth rate in induced pluripotent stem cells

Lee BN, Taylor HJ, Cipriani F, et al.

Induced pluripotent stem cells (iPSCs) enabled the generation of diverse cell types; however, certain fundamental biological properties, such as the genetic and epigenetic determinants of proliferation, remain poorly characterized. We quantified proliferation across 602 unique …

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Bioinformatics
Full text 2025

Sports Nutrition: Current and Novel Insights

Nieman DC.

This Special Issue invited the submission of sports nutrition-based manuscripts that advanced scientific understanding and provided novel insights on all aspects of performance and recovery [...].

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Bioinformatics
Full text 2026

Multiomics: the intersection of personalized nutrition in cardiometabolic diseases

Çelik E, Kocyigit E, Bingöl FG, et al.

BACKGROUND: Cardiometabolic diseases are among the leading causes of increasing morbidity and mortality worldwide. However, current population-based dietary recommendations do not sufficiently account for biological differences between individuals and therefore do not have the same …

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Bioinformatics Epigenetics Metagenomics
Full text 2026

RNA polymerase II: the elephant in the room

Henikoff S, Hahn S.

How genes respond to external signals is poorly understood, with transcription factors and histones proposed as mediators of signals to RNA polymerase II (Pol II). However, recent work shows that Pol II is the direct …

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Bioinformatics