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Affinity Proteomics-Based Non-Invasive Detection of Clinically Significant Liver Disease
<h4>Background</h4>Non-invasive biomarkers predicting major adverse liver outcomes (MALO) are urgently needed.<h4>Aims</h4>We assessed a novel, proximity extension assay-based high-throughput targeted proteomics.<h4>Methods</h4>Plasma proteomic data (> 2900 proteins) and clinical information were accessed from the population-based UK Biobank …
Read PDFProteomic and Metabolomic Analyses of HPV-Positive High-Grade Squamous Intraepithelial Lesions
<b>Background/Objectives</b>: Long-term exposure to high-risk human papilloma virus (HPV) leads to high-grade squamous intraepithelial lesions (HSILs), which may develop into cancer. Various proteins and metabolites change during the development of cervical cancer; thus, assessing the …
Read PDF<i>Pseudomonas aeruginosa</i> dynamically prioritizes motility and resource recycling during prolonged starvation
Heterotrophic bacteria rapidly deplete essential macronutrients during growth and must navigate subsequent periods of growth arrest imposed by starvation. Nutrient limitations can be dynamic in nature, requiring ongoing regulatory adjustments involving new protein synthesis despite …
Read PDFMultimodal AI agents for capturing and sharing proteomics laboratory practice
No abstract available.
Read PDFProteoform Mapping Calls for a Combined Effort From Bottom-Up and Top-Down Proteomics
Proteomics has demonstrated that each protein consists of various proteoforms that provide an additional layer of biological data next to gene-, transcript-, or protein expression levels. As a result, proteome analyses are increasingly being complemented …
Read PDFImproved sex-specific cardiovascular risk prediction with multi-omics data in people with type 2 diabetes
<h4>Background</h4>To evaluate whether integrating proteomics, metabolomics, and a cardiovascular disease specific polygenic risk score (CVD-PRS) in the SCORE2-Diabetes model improves sex-specific 10-year prediction of major adverse cardiovascular events (MACE) in individuals with type 2 diabetes …
Read PDFIntegrated Proteomics and Metabolomics Analysis Reveals Potential Pathways Underlying Onion-Mediated Regulation of Spleen Immune Function in Liangshan Black Sheep
Feed additives play a crucial role in boosting livestock immunity, but their underlying molecular mechanisms are often incompletely understood. This study used integrated proteomics and metabolomics to systematically investigate the immunomodulatory effects of dietary fermented …
Read PDFGalectin-3 associates with NF-κB activation and mitochondrial redox-related protein signatures in catecholamine-induced stress cardiomyopathy
BACKGROUND: Acute catecholamine-induced myocardial stress contributes to several cardiac conditions, including takotsubo syndrome (TS), a life-threatening acute cardiac syndrome characterized by transient regional left ventricular dysfunction that lacks evidence-based therapy. Extracellular vesicles (EVs) reflect active …
Read PDFADAM10-Mediated Proteolytic Remodelling of Signalling and Adhesion Proteins on Brain Cell-Derived Small Extracellular Vesicles
Proteases are common components of extracellular vesicles (EVs), yet the extent and functional relevance of ongoing proteolytic activity on EV surfaces remain largely unexplored. Such activity could significantly influence EV function and identity, with likely …
Read PDFIntegrated multiomics profiling of amniotic fluid exosomes reveals dysregulated lipid and protein signatures in fetal 22q11.2 deletion syndrome
<h4>Background</h4>Amniotic fluid exosomes (AF-Exos) are pivotal carriers of biological information during fetal development; however, their role in 22q11.2 Deletion Syndrome (22q11.2DS) remains unclear. To elucidate the molecular mechanisms underlying fetal anomalies in 22q11.2DS, this study …
Read PDF<i>APOE4</i> Drives Sex- and Diet-Dependent Effects on AD-Like Pathology, Cognition, and Mitochondrial Function
Apolipoprotein E4 (<i>APOE4</i>) is the strongest genetic risk factor for Alzheimer's disease (AD), yet it's unclear how this allele promotes disease. While factors like diet and sex may modify AD susceptibility in <i>APOE4</i> carriers, the …
Read PDFPlasma proteomic markers predict risk for bowel resection in inflammatory bowel disease: a retrospective cohort study
<h4>Background</h4>Bowel resection is required in up to 27% of inflammatory bowel disease (IBD) patients due to severe complications. Identifying reliable predictors for future surgery is crucial for risk stratification and management.<h4>Materials and methods</h4>We retrospectively analyzed …
Read PDFPredicting protein cascade expression from H&E images
Protein expression within oncogenic or suppressive pathways is a hallmark indicator of oncogenesis. While traditional AI models in digital pathology attempt to predict singular proteins, there is a need to predict the downstream expression of …
Read PDFProximity labeling proteomics maps radial glial ciliary proteins across the developing telencephalon
Primary cilia in radial glia act as signaling hubs essential for brain development, yet their molecular roles remain poorly understood. Here, using proximity-labeling-mediated in vivo proteomics, we systematically mapped ciliary proteins in the developing telencephalon. …
Read PDFA Preliminary proteomics-based assessment of biotic indicators in Central Mexican water bodies biotic indicators by proteomics in Mexican water bodies
Human activities such as industrialization, recreation, domestic water use, agriculture, and energy production have significantly increased pollution in water bodies, especially within urban regions. This pollution affects ecological biodiversity, exerting broad impacts on various environmental …
Read PDFBerberine signature and cardiometabolic diseases using randomized controlled trial, cohort study and Mendelian randomization
Berberine lowers both lipids and glucose, yet its role on cardiometabolic disease risk remain unclear. Based on a randomized controlled trial of berberine (registered in ClinicalTrials.gov on Dec 2018, NCT03770325), leveraging proteomics and sex hormones …
Read PDFHDAnalyzeR: streamlining data analysis for biomarker research
<h4>Motivation</h4>Exploration of large-scale biological datasets remains a central challenge in computational biology. While many tools are available, they are often developed in isolation, leading to fragmented workflows, duplicated efforts, and limited reproducibility. There is a …
Read PDFProteome characterization of single gene deletion mutants lacking zinc finger µ-proteins in <i>Haloferax volcanii</i>
Microproteins (≤70 amino acids) have important and often essential roles in all kingdoms of life, influencing cell motility, regulation of membrane transport and as transcription factors. In the halophilic archaeon and model system <i>Haloferax volcanii</i> …
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