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Anticancer Activity of the Antimicrobial Myristoylated Peptide Myr-B in HeLa Cells: Cytotoxic, Membrane-Disruptive and Proteomic Insights
Antimicrobial peptides (AMPs) are natural bioactive peptides produced by all organisms-from plants to insects, microbes and animals-and constitute a first line of defense. As they exhibit a broad spectrum of activity (antibacterial, antiviral, antifungal, antiparasitic, …
Read PDFTyloxapol inhibits ESX-1 secretion in <i>Mycobacterium marinum</i>
Mycobacteria have a hydrophobic cell envelope that makes uniform growth in liquid culture challenging. Non-ionic detergents, including Tween-80 and tyloxapol, are commonly added to media when culturing mycobacterial species in the laboratory. Tyloxapol was reported …
Read PDFComparative Proteomic Profiling of Microdissected Spindle and Epithelioid Uveal Melanoma Subtypes
<h4>Purpose</h4>Uveal melanoma (UM), the most prevalent primary intraocular cancer in adults, is defined by salient histopathological diversity. Spindle and epithelioid cells constitute its two dominant pathological lineages, yet the latter foreshadows aggressive behavior and shortened …
Read PDFMass spectrometry-based human spatial omics: fundamentals, innovations, and applications
Mass spectrometry-based spatial omics is a powerful approach for visualizing the spatial organization of proteins, metabolites, lipids, and other biomolecules in situ, combining the molecular depth of mass spectrometry with spatially resolved imaging. This systematic …
Read PDFMulti-Omics Reveals Dysregulation of the Endosome-Lysosome-Autophagy Axis and Immune-Inflammatory Imbalance in Elderly Sepsis
<h4>Background</h4>Elderly sepsis (ES), characterized by dual insults of aging and sepsis, is associated with substantial morbidity and mortality and exhibits distinct pathophysiological features. Elucidating these unique mechanisms is critical for developing precise therapeutic strategies and …
Read PDFUsing magnetic nanoparticles to explore symbiotic interactions
All plants and animals form symbiotic associations with microbes, yet many of the underlying mechanisms associated with these interactions remain uncharacterized. There are inherent challenges to studying the cellular and metabolic interactions between eukaryotes and …
Read PDFPlasma Proteomic Signatures of Glucose Metabolism Disturbances and Early Diabetes
Postprandial variability in glucose and protein levels is one of the elements of insulin resistance (IR) and prediabetes, which is an area precursor to type 2 diabetes mellitus (DM). The objective of the study was …
Read PDFProteome-based molecular subtyping and therapeutic target prediction in cervical cancer
Cervical cancer (CC) represents a leading malignant threat to women’s health globally. Patients with advanced-stage CC frequently encounter limited therapeutic efficacy and prominent drug resistance, highlighting the urgent need for molecular-driven precision treatment strategies. Herein, …
Read PDFGlobal Research Landscape on Plastic Microfibers in Sludge Treatment: Proteomic Mechanisms and Biotechnological Pathways for Biomass Valorization
Plastic microfibers (PMFs) increasingly accumulate in wastewater treatment plants, impairing sludge dewatering and raising operational costs. This study combines a bibliometric analysis (2000-2025) with a critical review of the recent mechanistic literature to map the …
Read PDFHarnessing mass spectrometry-based proteomics for continuous directed evolution
Continuous directed evolution is a powerful Synthetic Biology tool to engineer proteins with desired functions <i>in vivo</i>. Mimicking natural evolution, it involves repeated cycles of high-frequency mutagenesis, selection, and replication within platform cells, where the …
Read PDFMulti-Omics Identification of Biomarkers for High-Altitude Pulmonary Hypertension
(1) Aim: The incidence of high-altitude pulmonary hypertension (HAPH) has risen in recent years and is expected to continue increasing; however, its diagnosis remains challenging. In this study, we employed proteomics and metabolomics to identify …
Read PDFVibe Coding Omics Data Analysis Applications
Building custom data analysis platforms has traditionally required extensive software engineering expertise, limiting access for many researchers. Here, I demonstrate that modern large language models (LLMs) and autonomous coding agents can dramatically lower this barrier …
Read PDFSarcopenia Among Older Adults: Epidemiology, Proteomics, Technology and Biomarkers
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