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Optic neuritis (ON) and neuromyelitis optica spectrum disorders (NMOSD) are inflammatory neuro-ophthalmological conditions characterized by significant visual impairment and diverse clinical manifestations. Advances in diagnostic biomarkers have improved disease identification, including aquaporin-4 immunoglobulin G (AQP4-IgG) …
Read PDFBioinformatics plays an ever-increasing role in revealing the complexity of genomic information and how it is related to the susceptibility and pathophysiology of human diseases [...].
Read PDFThe objective of this review is to synthesize current knowledge and evidence on male reproductive health by addressing preventive medicine strategies and biomarkers, as well as to provide clinicians, researchers, and policy makers with a …
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Read PDF<h4>Background</h4>The Multi-Omics for Mothers and Infants (MOMI) Consortium aims to define biological mechanisms associated with preterm birth, small for gestational age, preeclampsia, and stillbirth. Globally, the burden of adverse pregnancy outcomes (APOs) is highest in …
Read PDFGastroenteropancreatic neuroendocrine tumours (GEP-NETs) are commonly treated with radio-ligand therapy (RLT) but reliable biomarkers for predicting early disease progression are lacking. In this exploratory study we investigated whether microRNA (miRNA) expression in archival samples is …
Read PDFThe worldwide rise of neurological and psychiatric conditions poses major challenges. However, current global research remains fragmented, dominated by limited cohorts and poorly integrated datasets that disconnect whole-body health, exposome, and brain health. Theories rarely …
Read PDF<b>Background</b>: Obesity is a major global public health issue with no fully satisfactory solutions. Most nutritional interventions rely on caloric restriction, with varying degrees of success. Very low-calorie ketogenic diets (VLCKD) have demonstrated rapid and …
Read PDFObstructive sleep apnea (OSA) remains underdiagnosed and inadequately managed despite an explosion in multimodal data and swift progress in artificial intelligence (AI). To elucidate the extent of AI techniques utilized in OSA data resources, we …
Read PDF<h4>Background and aim</h4>Pregnancy and early lactation in small ruminants are characterized by heightened metabolic activity and increased production of reactive oxygen species, predisposing animals to oxidative stress and reduced productivity. Despite extensive research in dairy …
Read PDF<h4>Purpose</h4>To explore the role of nanoimmunobiotechnomedicine in depression management, emphasizing how nanotechnology and immunobiology offer innovative approaches to understanding and treating depression. We investigated the molecular mechanisms underlying depression and integrated multi-omics approaches such as …
Read PDFNon-communicable diseases (NCDs) impose an overwhelming burden on global health systems. Prevailing healthcare for NCDs remains largely hospital-centered, episodic, and reactive, rendering them poorly suited to address the long-term, heterogeneous, and multifactorial nature of NCDs. …
Read PDFPrecision healthcare is increasingly oriented toward the development of therapeutic strategies that are as individualized as the patients receiving them. Central to this paradigm shift is artificial intelligence (AI)-enabled multi-modal data integration, which consolidates heterogeneous …
Read PDF<h4>Background</h4>Low-dose computed tomography (LDCT) lung cancer screening can reduce mortality in high-risk individuals, but many individuals with a heavy smoking history may be reluctant to undergo radiologic examinations. A non-invasive blood test might help overcome …
Read PDFDiabetic retinopathy involves early retinal vascular barrier breakdown and pericyte loss, yet the initiating molecular events remain poorly defined. Vascular endothelial cadherin (VE-cadherin), a key regulator of endothelial integrity, is notably reduced in diabetic and …
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