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DDX3X, a DEAD-box RNA helicase, has been identified as a risk gene for autism spectrum disorder (ASD). To elucidate the role of DDX3X mutations in ASD pathogenesis, HT22 cell models and mouse models with Ddx3x …
Read PDF<h4>Introduction</h4>Few genetic studies on Alzheimer's disease (AD) have incorporated multiple ancestries and omic datasets to pinpoint actionable AD risk effectors for each ancestry.<h4>Methods</h4>Here, we first performed genetic colocalization between molecular phenotypes (proteomics and metabolomics) from …
Read PDFThis Data Descriptor presents a comprehensive LC-MS/MS-based muscle proteome dataset for Clarias magur subjected to sustained sub-lethal thermal stress. Fish were maintained at a control temperature of 26 °C or gradually warmed at a rate …
Read PDF<h4>Objective</h4>Meningioma is the most common primary brain tumour. Invasion into the brain is a diagnostic feature of grade II meningiomas and is associated with recurrence and poor prognosis. Mebendazole is a microtubule inhibitor typically prescribed …
Read PDF<h4>Background</h4>The growing prevalence of cardiovascular diseases (CVDs) has created an increasing demand for alternative biologically functional vascular grafts. Among the explored tissue engineering strategies, decellularization provides a means to generate suitable acellular scaffolds from donor …
Read PDF<h4>Background</h4>Formalin-fixed paraffin-embedded (FFPE) tissue proteomics has emerged as a promising approach for precision medicine, offering access to vast clinical archives. Despite technological advances enabling identification of thousands of proteins from FFPE samples, no proteomic diagnostic …
Read PDFGlycosaminoglycans (GAGs) and their degrading enzymes have extensive applications and biotechnology and medicine, and play a crucial role in the recycling of organic matter in oceans. In this study, a potential GAG utilization gene cluster …
Read PDFViral proteases are essential enzymes in many viral strains, playing a crucial role in the viral replication cycle. They are key targets for antiviral drug development and have significant implications for viral pathogenesis. To address …
Read PDFHigh-throughput proteomic profiling provides a comprehensive analysis of systemic cancer effects and tumor microenvironment interactions. Characterizing soluble proteins driving inflammation in acute myeloid leukemia (AML) offers insight into inflammatory diseases like differentiation syndrome related to …
Read PDFThe cellular secretome is a rich source of biomarkers and extracellular signaling molecules, but proteomic profiling remains challenging, especially when processing culture volumes greater than 5 mL. Low protein abundance, high serum contamination, and sample …
Read PDFThe airway epithelium is the first site of injury from cigarette smoke (CS), a major risk factor for chronic lung disease including idiopathic pulmonary fibrosis (IPF). Here, we report the first intracellular proteomic analysis of …
Read PDFProteomic experiments, particularly those addressing dynamic proteome properties, time series, or genetic diversity, require the analysis of large sample numbers. Despite significant advancements in proteomic technologies in recent years, further improvements are needed to accelerate …
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Read PDFBACKGROUND: Hepatocellular carcinoma (HCC) is a lethal malignancy with limited treatment options. UBC9, the sole E2 conjugating enzyme in the SUMOylation pathway, is frequently overexpressed in HCC, yet its specific role in hepatocarcinogenesis remains unclear. …
Read PDFAlcohol-associated liver disease (ALD) is a prevalent chronic liver disease worldwide, with unclear pathogenesis and limited effective treatments. <i>Mori Fructus</i> polysaccharide (MFP-1) exhibits good therapeutic potential for ALD, but its mechanism remains unclear. This study …
Read PDF<sup>177</sup>Lu-PSMA-617 represents a transformative treatment for metastatic castration-resistant prostate cancer (mCRPC), yet biomarkers of benefit beyond prostate-specific membrane antigen positron emission tomography (PSMA-PET) imaging remain lacking. Here, we present findings from a prospective study of …
Read PDF<h4>Background</h4>Given the persistence of the SARS-CoV-2 virus, it is important to understand the proteome associated with breakthrough infections among COVID-19 vaccinated individuals.<h4>Methods</h4>We conducted a nested case-control study within the frontline worker HEROES-RECOVER cohorts to specify …
Read PDFAccurately measuring complexoform dynamics (i.e., composition and/or abundance changes) in cells is vital for advancing fundamental and translational research. In this work, we present a pilot study establishing capillary zone electrophoresis (CZE)-mass spectrometry (MS)-based quantitative …
Read PDFFibrosis is characterised by inappropriate wound healing and the buildup of excessive fibrous connective tissue, in particular within the extracellular matrix (ECM). This can occur in multiple organs, ultimately leading to organ failure. Despite the …
Read PDF<h4>Objective</h4>Blood-Heat syndrome is a core syndrome of Traditional Chinese Medicine (TCM) in Henoch-Schönlein purpura nephritis (HSPN), yet its biological basis remains unclear. This study aimed to systematically elucidate the scientific basis of Blood-Heat syndrome within …
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