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<h4>Background</h4>Breast cancer is a malignant tumor characterized by metastasis. It first spreads through the lymphatic system to lymph nodes of various levels and can subsequently metastasize to distant organs via the bloodstream. Therefore, identifying protein …
Read PDFA crucial step in processing mass spectrometry-based proteomics data is identifying and quantifying the proteins in the sample. While the existing search engines can easily match tandem mass spectra to peptide sequences, selecting the most …
Read PDFApolipoprotein E (APOE) is essential for lipid homeostasis and has been extensively studied in Alzheimer's disease (AD). Individuals carrying an <i>APOE4</i> allele have an increased risk of AD and exhibit deficits in energy metabolism, including …
Read PDFChronic pancreatitis (CP) is characterized by chronic pancreatic inflammation and progressive fibrosis. This study investigated the role of ubiquitin-specific peptidase 1 (USP1), a protein-stabilizing deubiquitinase, in CP. C57BL/6J mice were given 8-week repetitive intraperitoneal cerulein …
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Read PDF<h4>Objective</h4>Diabetic macular edema (DME) with incomplete response to anti-VEGF therapy is a significant challenge. Here, we integrated advanced proteomics and an artificial intelligence (AI)-driven platform to elucidate molecular mechanisms associated with resistance to anti-VEGF treatment.<h4>Design</h4>Translational …
Read PDFHyperhomocysteinemia (HHcy) is an independent risk factor for thrombotic cardiovascular events. We previously demonstrated that homocysteine (Hcy) amplifies platelet activation by promoting membrane remodeling and enhancing signaling through surface platforms such as integrin αIIbβ3 and …
Read PDFARF1 plays a crucial role in maintaining the structure and function of the Golgi apparatus, yet the precise on-site regulatory mechanism governing ARF1 activation remains incompletely understood. Here, we have uncovered a novel regulatory mechanism …
Read PDF<h4>Background</h4>To develop a new non-invasive screening method for sepsis by detecting urine samples.<h4>Methods</h4>A prospective study was conducted to collect urine samples from a cohort of 22 individuals diagnosed with sepsis and admitted to the Intensive …
Read PDF<h4>Background/aim</h4>Colorectal cancer (CRC) is a leading cause of cancer-related mortality worldwide, with limited effective targeted therapies. Metabolic reprogramming is a hallmark of cancer, and post-translational modifications (PTMs), such as phosphorylation, ubiquitination, and malonylation, play critical …
Read PDFBACKGROUND: Age-related diminished ovarian reserve (DOR) exhibits marked significant individual variation. Some women of advanced age with normal ovarian reserve (NOR) achieve better reproductive outcomes than age-matched DOR patients. OBJECTIVE: This study aimed to compare …
Read PDFEndometrial cancer (EC) is the leading gynecological malignancy worldwide. Obesity is reported to be associated with 50% of EC cases. Significant gaps remain in investigating specific molecular mechanisms behind the obesity-driven EC. Women diagnosed with …
Read PDFRecent advances have shifted our understanding of the blood-brain barrier (BBB) not as a static wall, but as a dynamic and evolving system whose property is variable across the lifespan: acquisitive in early development, heterogeneous …
Read PDFValidation of biomarkers for clinical diagnostics requires high-quality samples and standardized protocols. This study investigated the effect of a single freeze-and-thaw (FT) cycle on the quality of liquid nitrogen-stored clinical serum samples. Using mass spectrometry, …
Read PDFTumor stiffening plays a pivotal role in cancer progression. Increased tumor stiffness, resulting from interactions between cancer cells and their surrounding microenvironment, alters the tumor's mechanical properties and significantly impacts cancer growth and metastasis, the …
Read PDFThis paper describes a detailed evaluation of published works, in which proteomics methodological approaches and technologies were used to advance knowledge about small ruminants. The specific objective of this assessment was the presentation of quantitative …
Read PDFMaternal immune activation during pregnancy has been associated with abnormal infant neurodevelopment. During the COVID-19 pandemic, we enrolled pregnant individuals with laboratory-confirmed SARS-CoV-2 infection into a cohort study conducted in Los Angeles, United States, and …
Read PDFPrecise differentiation between closely related species is crucial for effective clinical diagnosis and treatment. <i>Haemophilus influenzae</i> and <i>Haemophilus aegyptius</i> are phenotypically similar but differ in pathogenic potential, with <i>H. influenzae</i> involved in respiratory and invasive …
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