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Selective protein terminal labeling has become essential for system-wide studies of proteolytic mechanisms in disease. These methods enable precise tracking of cleavage dynamics, protease interactions, and cellular networks, offering transformative potential for proteolytic event analysis. …
Read PDFDiabetic peripheral neuropathy (DPN) is a common complication of diabetes and there are currently no biomarkers for DPN in clinical practice. The objective of this study was to explore the diagnostic value of urine for …
Read PDFThe BioSamples database (https://www.ebi.ac.uk/biosamples/) at the European Bioinformatics Institute (EMBL-EBI) is a core infrastructure resource that provides a centralized platform for the storage, curation, and dissemination of biological sample metadata. BioSamples holds sample descriptions across …
Read PDFBiological nanoscale assemblies transfer proteins and RNAs between cells and cellular compartments. Nonetheless, it is unclear if exogenous and synthetic nanostructures affect these molecular assemblies and processes. Here we report nanostructure-biological hybrid complexes that are …
Read PDF<h4>Background</h4>Establishing continuous cell lines is hindered by limited molecular resolution of culture establishment and the transition to sustained proliferation. Here, proteome changes across passages were quantified in two independently derived California grunion (Leuresthes tenuis) embryonic-derived …
Read PDFThis study aimed to elucidate the effects and underlying mechanisms of Abrus cantoniensis in treating mice hepatic fibrosis, thereby providing a rationale for its clinical application. To investigate A. cantoniensis effects in hepatic fibrosis, we …
Read PDFBull fertility impacts herd fertility, but accurately predicting male fertility from sperm characteristics is difficult once extremes are removed. The objectives of this study were identification, relative quantification, and comparison of sperm head plasma membrane …
Read PDF<h4>Background</h4>PGM1-congenital disorder of glycosylation (PGM1-CDG) is frequently associated with cardiomyopathy. Although galactose therapy corrects glycosylation defects, cardiac dysfunction typically persists, suggesting a glycosylation-independent mechanism. Recent evidence of mitochondrial abnormalities in PGM1-deficient human and murine heart, …
Read PDFThe reality of an aging population demands a deeper understanding of aging as a biological process, rather than as a chronological descriptor. Chronological age poorly captures interindividual heterogeneity in physiological and functional decline, disease susceptibility, …
Read PDFImmunomodulatory imide drugs (IMiDs) like lenalidomide and pomalidomide are effective in treating multiple myeloma (MM) but pose hematotoxicity risks by degrading neosubstrates Ikaros (IKZF1) and Aiolos (IKZF3). When these IMiD scaffolds are integrated into proteolysis …
Read PDFHigh-throughput proteomics requires efficient and highly reproducible sample processing, yet workflows─particularly for PTM profiling─remain complex and costly to fully automate. Here, we present a practical intermediate solution using manually operated 96-channel devices: the Gilson Platemaster …
Read PDFChlorogenic acid (CGA), which is ubiquitous in diverse botanical sources, demonstrates considerable anticancer potential through modulation of multiple targets or signaling pathways, thereby posing substantial challenges for mechanistic elucidation and target identification. Based on the …
Read PDFEscalating insecticide resistance in mosquito vectors threatens the durability of vector-borne disease control and increasingly constrains the effectiveness of core interventions. This resistance is a multilayered adaptive phenotype arising from the combined action of target-site …
Read PDFMissing values are a major challenge in the analysis of mass spectrometry proteomics data. Missing values hinder reproducibility, decrease statistical power for identifying differentially abundant proteins, and make it challenging to analyze low-abundance proteins. We …
Read PDFThe family of sulfur mustards, as potent alkylating agents, has been used as chemical warfare agents for over a century. The retrospective verification of exposure and, hence, the confirmation of alleged use of such agents, …
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