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Integrating Omics Data and AI for Cancer Diagnosis and Prognosis
Cancer is one of the leading causes of death, making timely diagnosis and prognosis very important. Utilization of AI (artificial intelligence) enables providers to organize and process patient data in a way that can lead …
Read PDFClimate informed precision health
Precision healthcare requires incorporation of climate-related factors relevant to the patient. There is a critical need for healthcare systems to incorporate environment and community vital signs into electronic health records to facilitate incorporation of climate-related …
Read PDFNew insights on potency assays from recent advances and discoveries in CAR T-cell therapy
This review explores recent advances in the characteristics and manufacturing of CAR T-cell products. Traditional potency assays have been designed based on well-established CAR T-cell functionalities. However, the advent of innovative tools and methodologies has …
Read PDFSepsis subphenotypes: bridging the gaps in sepsis treatment strategies
Sepsis, a heterogeneous illness produced by a dysregulated host response to infection, remains a severe mortality risk. Recent discoveries in sepsis research have stressed phenotyping as a feasible strategy for tackling heterogeneity and enhancing therapy …
Read PDFComputational modelling of cell identity
Deciphering cell identity remains a central challenge in biology, as experimental profiling can only capture a fraction of the molecular diversity across human cell states. Computational modelling fills this gap by offering scalable predictions beyond …
Read PDFLC-MS/MS-Based Metabolomics Identifies 2-Aminopurine as a Predictive Freshness Biomarker in Goose Egg Yolk During Refrigerated Storage
Goose yolk, the primary source of nutrients and flavor, is particularly susceptible to quality deterioration during storage, yet its metabolic dynamics remain poorly characterized. To elucidate these changes, we combined physicochemical assays with untargeted LC-MS/MS …
Read PDFMultiomics Research: Principles and Challenges in Integrated Analysis
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Read PDFPredicting Future Respiratory Hospitalizations in Extremely Premature Neonates Using Transcriptomic Data and Machine Learning
<h4>Background</h4>Extremely premature neonates are at increased risk for respiratory complications, often resulting in recurrent hospitalizations during early childhood. Early identification of preterm infants at highest risk of respiratory hospitalizations could enable targeted preventive interventions. While …
Read PDFPerspectives in Amyotrophic Lateral Sclerosis: Biomarkers, Omics, and Gene Therapy Informing Disease and Treatment
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by the progressive loss of upper and lower motor neurons, leading to muscle weakness, paralysis, and ultimately respiratory failure. Despite advances in understanding its genetic …
Read PDFClass IIa HDACs Are Important Signal Transducers with Unclear Enzymatic Activities
Class IIa histone deacetylases (HDACs) are pleiotropic regulators of various differentiation pathways and adaptive responses. They form complexes with other co-repressors and can bind to DNA by interacting with selected transcription factors, with members of …
Read PDFDevelopment of a Quantitative Serial LC-MS/MS Method for Gut Microbiota Metabolomics
The significance of gut microbiota in human health has gained increasing attention. Accordingly, metabolomics has been used to elucidate host-microbiota interactions. Liquid chromatography-tandem mass spectrometry (LC-MS/MS) is an ideal choice for metabolome analysis of gut …
Read PDFMulti-omics perspectives for gastrointestinal malignancy: A systematic review
<h4>Background</h4>Gastrointestinal (GI) malignancies, including gastric and colorectal cancers, remain one of the primary contributors to cancer-related illness and death globally. Despite the availability of conventional diagnostic tools, early detection and personalized treatment remain significant clinical …
Read PDFInvestigating human lung resilience, its evolutionary history and its relation to COPD
A subset of long-term smokers remain free of chronic obstructive pulmonary disease or lung cancer, a phenomenon termed "lung resilience." Understanding this resilience could reveal protective mechanisms that preserve respiratory health, yet conceptual and methodological …
Read PDFGenetic, Psychological, and Behavioural Factors Associated with Subtypes of Pain-Related Temporomandibular Disorders
<b>Background:</b> This genetic association study investigated single nucleotide polymorphism (SNP) in interleukin-8 (<i>CXCL8</i>) and opiorphin (<i>OPRPN</i>) genes, as well as psychological characteristics and oral behaviours, between patients with pain-related temporomandibular disorders (TMDp) and healthy controls. …
Read PDFQuantifying TERT promoter mutations in tumor-derived DNA shed into the oral cavity as a potential biomarker for oral squamous cell carcinoma
<h4>Background</h4>Head and neck squamous cell carcinomas (HNSCC) have high recurrence and poor prognosis, largely due to delayed diagnosis. Identification of somatic mutations and human papillomavirus (HPV) sequences in tumor DNA shed in the oral cavity …
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