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<h4>Purpose</h4>This study aims to comprehensively analyze the evolution of Biochemistry and Molecular Biology (BMB) education research from 2000 to 2025, with a specific focus on identifying global trends, research hotspots, term networks, and the integration …
Read PDFBACKGROUND : Feature generation drives machine learning-based drug discovery by producing unique, compact, invariant, and computationally efficient descriptors. In structural protein–ligand binding affinity prediction, machine learning has developed a range of feature generation methods, with …
Read PDFEarly and accurate diagnosis remains a major challenge in cervical cancer management. This study aimed to identify reliable diagnostic biomarkers for cervical cancer by integrating bioinformatics and machine learning approaches and to further validate their …
Read PDF<h4>Motivation</h4>Molecular mimicry is used by pathogens to evade the host immune system and manipulate other host cellular processes. It is often mediated by short motifs in non-homologous proteins, whose detection challenges the sensitivity and specificity …
Read PDF<h4>Summary</h4>Uchimata is a toolkit for visualization of 3D structures of genomes. It consists of two packages: a Javascript library facilitating the rendering of 3D models of genomes, and a Python widget for visualization in Jupyter …
Read PDF<h4>Motivation</h4>This work presents the first large-scale neutral benchmark experiment focused on single-event, right-censored, low-dimensional survival data. Benchmark experiments are essential in methodological research to scientifically compare new and existing model classes through proper empirical evaluation. …
Read PDF<h4>Introduction</h4>Acute Myeloid Leukemia (AML) is a heterogeneous hematological malignancy with poor prognosis, despite therapeutic advances. Gene expression analysis has emerged as a powerful tool for identifying novel biological markers that can aid in predicting patient …
Read PDF<h4>Background</h4>Bacterial lipopolysaccharide (LPS) play a crucial role in triggering dysregulated immune responses in pediatric septic shock, profoundly influencing disease onset and progression. This study systematically investigated the differential expression of LPS-related genes, constructed diagnostic models, …
Read PDF<h4>Background and objective</h4>Colon cancer (CC) is a highly prevalent malignant tumor with a high mortality rate worldwide. Despite recent advancements in diagnosis and treatment, the overall prognosis for patients remains poor, especially for those with …
Read PDFProtein-protein interactions (PPIs) play a central role in regulating cellular processes. However, the identification and characterization of senescence-associated PPIs remain challenging. In this study, we developed and evaluated an integrative methodology based on selective proteomics …
Read PDFGenomic sequencing has become a key tool in the investigation of foetal anomalies, with a growing shift from targeted panels to exome and genome sequencing. These broader approaches generate significantly more data, underscoring the need …
Read PDF[This corrects the article DOI: 10.3389/fmed.2024.1500216.].
Read PDF<h4>Background</h4>Mendelian randomization (MR), polygenic risk score (PRS), Geno Ontology (GO), and the Kyoto Encyclopedia of Genes and Genomes (KEGG) are powerful bioinformatic analysis tools. However, the analysis of MR, PRS, GO, and KEGG may pose …
Read PDF<h4>Summary</h4>FASTA is a widely used text-based format for storing nucleotide and protein sequences. The existing FASTA compressors usually focus on (slightly) improving the compression ratio, not on practical performance. We present FFC, a scalable FASTA …
Read PDFSpatially resolved sequencing technologies have revolutionized our understanding of biological regulatory processes within tissue microenvironments by simultaneously capturing the states of genomic regions, genes, and proteins alongside the spatial organization of cells. However, inherent heterogeneity …
Read PDF<h4>Background</h4>Metabolic syndrome (MetS) comprises various complicated metabolic disorders. Coronary artery disease (CAD) is a major cardiovascular disease worldwide. These two diseases are the principal causes of morbidity and mortality in older adults. Previous studies have …
Read PDF<h4>Motivation</h4>Cell annotation is fundamental for single-cell data interpretation. Accurate annotation allows us to identify cell types, understand their functions, trace developmental trajectories, and pinpoint alterations associated with a condition of interest. However, this complex process …
Read PDFThe Cross-Wellcome Africa Asian Programmes (AAPs) Acceleration of Genomics for Escalating Infectious Diseases (CAGED) Consortium is a collaboration among six institutions: the Africa Health Research Institute, the Center for Infectious Disease Research in Africa, the …
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