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Antimicrobial resistance (AMR) has emerged as one of the most significant global threats to public health, food safety, and environmental sustainability [...].
Read PDF<h4>Objective</h4>To investigate the perceptions of the participants having attended the International Training Program on Molecular Diagnosis and Pathogen Determination (ModPad) about its enhancing effect on their molecular diagnostic capacity as well as related public health …
Read PDFBACKGROUND: Platycodin D (PD) is a typical triterpenoid saponin with low oral bioavailability. Despite its potent anti-ALI effects, its active metabolites and underlying mechanisms remain unclear, thereby significantly impeding its further development. This study aimed …
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Read PDF<h4>Background</h4>Foot-and-mouth disease (FMD) is a contagious disease affecting cloven footed animals. Existing vaccines although effective, has limitations of short immunity, needs cold chain maintenance, high biosafety levels facilities for production and inability to differentiate infected …
Read PDF<h4>Motivation</h4>Protein folding is a dynamic process during which a protein's amino acid sequence undergoes a series of 3D conformational changes en route to reaching a native 3D structure; these conformations are called folding intermediates. While …
Read PDFPURPOSE: This study aimed to identify the key genes involved in the development of AAA by various bioinformatics methods and explore their potential mechanisms. METHODS: Feature genes were screened by machine learning and other methods, …
Read PDF<h4>Motivation</h4>In the past decades, many statistical methods for integrating multi-omics data have been developed. They have been implemented into software tools, which differ widely in their programming choices, such as the format required for data …
Read PDFAgricultural research has long faced challenges with data sharing, often relying on informal networks and requiring significant effort to clean and harmonize data. This hampers collaboration and limits data reuse. While FAIR (Findable, Accessible, Interoperable, …
Read PDF<h4>Purpose</h4>To identify an endoplasmic-reticulum-stress-related candidate gene in chronic obstructive pulmonary disease (COPD) lung tissue and assess its internal discriminative performance and cross-cohort reproducibility.<h4>Patients and methods</h4>This bioinformatics study used the GSE57148 lung tissue dataset (98 COPD …
Read PDF<h4>Motivation</h4>Bioinformatics drives modern biological discovery, and Brazil has become an important contributor to genomics and computational biology. However, bioinformatics education across the country struggles to meet diverse regional and professional demands. To respond to these …
Read PDFThe complete genome sequence of the strain GD386 of <i>Mycobacterium avium</i> subspecies <i>hominissuis</i> isolated from a patient with lung infection in France was determined. The genome was sequenced using the PacBio technology, yielding a genome …
Read PDFThe Ensembl project (https://www.ensembl.org) is a public and open resource providing access to genomes, annotations, high-quality tools, and methods applicable to species from across the tree of life. This year has witnessed nearly a doubling …
Read PDF<h4>Motivation</h4>Identifying sequence constraint across long evolutionary distances is a powerful method for the discovery of functional genomic sequences, especially putative non-coding elements. Conserved elements have been a mainstay of comparative genomic research, and can be …
Read PDF<h4>Summary</h4>Hydrogen-Deuterium Exchange Mass Spectrometry (HDX-MS) monitors deuterium uptake at the peptide level, in a time-dependent manner. It produces complex, multi-dimensional data that must be interpreted at minimum both the temporal and sequence levels. Specialized tools …
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