Correction: Age-related reduction of pyruvate dehydrogenase kinase 1 impairs T cell responses
[This corrects the article DOI: 10.3389/fimmu.2026.1800870.].
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Characterization and expression analysis of UBC gene family provide insights into the potential roles in pigment biosynthesis in pepper fruit
<h4>Background</h4>Ubiquitin-conjugating enzymes (UBCs) are a critical part of the ubiquitin-proteasome pathway and play diverse roles in growth, development, and abiotic stress responses in pepper (Capsicum annuum L.). Although UBC genes have been reported in several …
Read PDFIndigenous sovereignty and the limits of the Canadian Precision Health Initiative
No abstract available.
Read PDFMultilevel Genetic and Functional Assessment of an ARR3 Frameshift Variant in Early-Onset High Myopia
<h4>Background</h4>Early-onset high myopia (eoHM) is a highly heritable ocular disorder, with pathogenic variants in the X-linked ARR3 gene (which encodes cone arrestin) being associated with a female-limited form of eoHM. However, the clinical manifestations of …
Read PDFDecoding disease and therapy through multiomics integration and systems analysis
Computational multiomics methods are based on machine learning methods, and are primarily used for classifying patients into subtypes, discovering novel biomarkers, drug repurposing, and advancing precision medicine. Advances in high-throughput technologies have enabled comprehensive profiling …
Read PDFIntegrative Genomic Analysis Reveals Pseudouridine Modification-Related Gene Signatures Associated With Prognosis and Therapeutic Response Patterns in Hepatocellular Carcinoma
<h4>Background</h4>Hepatocellular carcinoma (HCC) is a genomically heterogeneous malignancy with substantial variability in prognosis and therapeutic response. Pseudouridine (<i>Ψ</i>) modification is an evolutionarily conserved RNA modification involved in RNA structure stabilization and translational regulation; however, the …
Read PDFCorrection: Furin as target for suppression of mosquito-borne viruses
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Read PDFABRF 2026 Meeting Report
The 2026 Association of Biomolecular Resource Facilities (ABRF) annual meeting took place in Pittsburgh, Pennsylvania, from March 28-31, 2026, and brought scientific core directors, core staff, institutional leadership, and industry partners together into community to …
Read PDFWhen genomics companies act as biobanks: governance challenges in an era of genomic assetization
<h4>Introduction</h4>Contemporary genomics companies increasingly perform core biobanking functions-collecting, storing, and sharing large volumes of genetic data and biospecimens-without being widely recognized or governed as biobanks. At the same time, these holdings are increasingly undergoing assetization: …
Read PDFKCNQ2 neonatal epilepsy: Impact of prompt diagnosis and treatment, and early predictors of outcome severity
<h4>Objective</h4>To determine whether prompt genetic diagnosis in children with KCNQ2 neonatal epilepsy enabling targeted therapy is associated with improved outcomes, and identify early predictors of developmental outcomes.<h4>Methods</h4>Thirty-seven children with KCNQ2 neonatal epilepsy were recruited from …
Read PDFAccurate imputation of African cattle genomes using a diverse reference panel
<h4>Background</h4>In cattle, most commercial single-nucleotide polymorphism (SNP) genotyping arrays have been shown to be suboptimal for capturing genomic variation in non-European populations, particularly in African cattle. Low-coverage whole-genome sequencing (LCWGS) followed by imputation provides a …
Read PDFFrequency of familial hypercholesterolaemia-causing genetic variants in the 100 000 Genomes Project cohort: whole genome sequencing analyses of 77 260 participants
<h4>Background</h4>Heterozygous Familial Hypercholesterolaemia (HeFH) is caused by pathogenic variants in <i>LDLR</i>, <i>APOB</i>, <i>APOE</i> or <i>PCSK9</i>, leading to elevated low-density lipoprotein-cholesterol and increased cardiovascular risk. In the UK, HeFH affects ~1 in 288 individuals. The 100 …
Read PDFToward a Genomics-Driven Hepatology: Liver Biology, Precision Diagnosis, and the Rise in Genetic Therapies
The liver's anatomic position and immune specialization make it both a major target and a major filter for systemically delivered therapeutics. Because portal venous inflow exposes the liver early to gut-derived molecules and exogenous compounds, …
Read PDFGenome sequences of <i>Verticillium longisporum</i> strains M058 and M219, members of the A1D1 type-II lineage
We report chromosome-scale genome assemblies and annotations of two <i>Verticillium longisporum</i> A1D1 type-II strains, M058 and M219, isolated from oilseed rape in the United Kingdom and Germany. These high-quality genomes provide resources for studying hybrid …
Read PDFResearch Trends and Emerging Frontiers in Racehorse Genetics: A Bibliometric Analysis
The global horse racing industry relies heavily on elite breeding. Therefore, a molecular understanding of athletic traits is crucial for the industry's advancement. This study utilized Bibliometrix, VOSviewer, and CiteSpace to conduct a comprehensive bibliometric …
Read PDFThe Importance of the <i>Physcomitrium patens</i> Genome in the Evolutionary Genomics of Terrestrial Plants
Mosses (Bryophyta) comprises a group of terrestrial plants that colonized land more than 450 million years ago that play fundamental ecological and evolutionary roles, particularly in polar and peatland ecosystems. The sequencing of <i>Physcomitrium patens</i> …
Read PDFGeneScanner: profiling genetic variation across bacterial populations
Rapid, low-cost genome sequencing has transformed microbiology, advancing efforts to link genetic and phenotypic variation across diverse bacterial systems. Laboratory functional screens now uncover causal mechanisms underlying key traits in simplified systems, such as drug …
Read PDFPangenomics insights of enterococcus faecium human isolates and identification of novel therapeutic targets by in silico subtractive genomics
Enterococcus faecium is a Gram-positive bacteria that infects the human gastrointestinal tract and it is a leading cause of hospital-acquired infections, due to its ability to cause various types of infections, such as endocarditis, bacteremia, …
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