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Editorial: Omics applications for pathogen control and disease resistance
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Read PDFGENOVIS: a Python package for the visualization of population genetic analyses
BACKGROUND: Despite its importance, generating clear and customisable figures remains challenging for researchers without a bioinformatic background. This is due to the fact that most population genetics tools target specific analyses and rely on language-specific …
Read PDFDraft genome sequence of epiphyte <i>Paenibacillus kyungheensis</i> strain Cap286 isolated from <i>Chenopodium album</i> L. leaves
Here, we report the genome sequence of the epiphytic <i>Paenibacillus kyungheensis</i> bacterium isolated from <i>Chenopodium album</i> L. leaves. The raw sequencing data were obtained using the NextSeq 1000 technology (Illumina). The assembly comprises two scaffolds, …
Read PDFA novel androgen receptor gene splice site mutation induces aberrant mRNA splicing and internal in-frame deletion in androgen insensitivity syndrome
Androgen insensitivity syndrome (AIS) is a disorder caused by pathogenic mutations in the androgen receptor (AR) gene, leading to androgen resistance and impaired sex differentiation in 46,XY individuals. Despite increasing recognition of AR mutations, the …
Read PDFDraft genome sequence of <i>Serratia proteamaculans</i> strain SK20 isolated from diseased rainbow trout (<i>Oncorhynchus mykiss</i>) in Türkiye
We report the draft genome sequence of <i>Serratia proteamaculans</i> strain SK20 isolated from diseased rainbow trout (<i>Oncorhynchus mykiss</i>) from an aquaculture facility in Türkiye. The genome is 5.38 Mb with 55% GC content and contains …
Read PDFSLC7A7 Downregulation in Monocytes Drives Immunosuppression and Osteosarcoma Progression
<h4>Background</h4>Metabolic reprogramming and the formation of an immunosuppressive tumor microenvironment(TME) are hallmarks of osteosarcoma (OS). However, the metabolic characteristics of OS and its associated immune microenvironment remain largely unknown.<h4>Methods</h4>The single-cell data were processed for dimensionality …
Read PDFWhole-genome characterization of halotolerant Enterobacter roggenkampii OSNO4 and its potential for climate-resilient agriculture
Plant growth-promoting rhizobacteria (PGPR) represent an eco-friendly strategy to improve crop yield under abiotic stress conditions. This study aimed to perform a comprehensive genomic and functional profiling of a halotolerant rhizobacterium to evaluate its multi-trait …
Read PDFEmerging trends and research hot spots in inborn error of immunity: A bibliometric perspective
<h4>Background</h4>Inborn errors of immunity (IEIs) are an expanding group of genetically defined disorders associated with infections, autoimmunity, and malignancy. Advances in high- throughput genomics and updates to international classifications have reformed the field, shifting from …
Read PDFComparative genomics links ecological dominance and genome plasticity in sediment-derived <i>Vibrio diabolicus</i>
Marine sediments harbor diverse <i>Vibrio</i> populations that play critical roles in benthic microbial ecology; however, the genomic determinants underlying the dominance of sediment-associated <i>Vibrio</i> taxa remain insufficiently characterized at the genome level. In this study, …
Read PDFBridging scales: integrated multi-omics and deep phenotyping for climate resilience in crop plants
Global changes in agricultural and environmental systems will necessitate new crop research methodologies in the future years to ensure more effective use of natural resources and food security. The progress in next-generation sequencing has led …
Read PDFVirus-induced gene editing of stomatal regulators in Nicotiana benthamiana enables rapid functional genomics
Virus-induced gene editing (VIGE) holds promise as a rapid and scalable approach for functional genomics in plants. Here, we apply a tobacco rattle virus (TRV)-based single-guide RNA (sgRNA) delivery system to target key regulators of …
Read PDFGenomic stewardship in Alzheimer's disease: a decade of insights from the NIAGADS platform
Fourteen years ago, Alzheimer's disease (AD) genetics entered an era of exponential data growth, but the infrastructure to support and steward that data had yet to catch up. Large-scale genomic discovery demands more than storage; …
Read PDFArtificial Intelligence in Rare Diseases: Workflow-Integrated Precision Kidney Care
Rare diseases affect over 300 million individuals worldwide yet remain underdiagnosed and poorly characterized due to fragmented data, small cohorts, and phenotypic heterogeneity. Advances in artificial intelligence (AI) are enabling integration of genomics, imaging, electronic …
Read PDFGenomics and Discrimination in New Zealand Health and Life Insurance
The use of genomics offers substantial benefits to society by revolutionising approaches to healthcare and personalised medicine. It enables early detection of genetic predispositions to various diseases, allowing for proactive and tailored treatment plans, access …
Read PDFUnderstanding randomized controlled trial generalizability through an embedded molecular diagnostics trial
<h4>Background</h4>Issues with randomized controlled trial generalizability are well described, but whether these issues result from differences in patient treatment across contexts remains unknown. We studied treatment of patients with high-risk prostate cancer after radical prostatectomy …
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