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Artificial intelligence (AI) is increasingly used in cancer research, enabling integrative analysis of complex biomedical data to identify actionable therapeutic vulnerabilities. This review specifically examines how AI advances mechanistic cancer target discovery and translational drug …
Read PDF<i>Pseudomonas bijieensis</i> BR-1-Y is an endophytic bacterium isolated from the medicinal plant <i>Stemona japonica</i> in Chongqing, China. Whole-genome sequencing revealed a single circular chromosome comprising 6,713,544 bp and containing 5,824 protein-coding genes, 65 tRNA genes, …
Read PDFAs mobile genetic elements, transposons play a crucial role in the adaptive evolution and genome engineering of industrial microorganisms. Their applications range from high-throughput functional genomics, enabling systematic genotype-phenotype mapping via transposon sequencing, to the …
Read PDFSecondary findings (SFs) from genome sequencing have significant implications for disease prevention and early intervention, yet their population-specific spectrum remains poorly characterized in non-European cohorts. We performed whole-genome sequencing of 6685 Chinese newborns and evaluated …
Read PDFBACKGROUND: May-Hegglin anomaly, a rare autosomal dominant disorder caused by MYH9 mutations, is characterized by the classic "triad" of thrombocytopenia, giant platelets, and granulocyte cytoplasmic inclusion bodies; some patients also present non-hematological symptoms. RESULTS: We …
Read PDFThe 2026 ABRF annual meeting, scheduled to take place in Pittsburgh from March 28 to 31, is anticipated to be a highly rewarding, vibrant, and engaging event for core laboratory personnel at all levels and …
Read PDFVarious endemic <i>Camellia</i> L. species have been identified in Vietnam. However, most genomic data of these endemic tea taxa have not been characterized. In the current study, we employed next-generation sequencing method to sequence and …
Read PDF<h4>Background</h4>This study presents a bibliometric and scientometric analysis of research trends in schizophrenia genetics over nearly 7 decades (1957-2025). The field has evolved from early heritability studies to genome-wide association studies and multi-omics approaches. The …
Read PDF<h4>Aim</h4>To validate a Competency Framework for Genomics Nurse Educators, strengthening the genomics-informed nursing workforce.<h4>Background/introduction</h4>A pressing global need for nurse educators equipped to build genomic literacy within the profession prompted the International Society of Nurses in …
Read PDFThe rapid growth of biological resources and associated research outputs has increased the complexity of resource discovery, access, and reuse across heterogeneous repositories. However, fragmented metadata schemas, limited interoperability, and siloed access mechanisms continue to …
Read PDF<b>Background</b>: Kawasaki disease (KD) is a systemic vasculitis of unknown origin, though recent evidence implicates viral pathogens in its pathogenesis. Given the central role of T cell receptors (TCRs) in antigen recognition and immune response, …
Read PDFShort tandem repeat expansions are associated with over 50 diseases, many with primary neurological presentations. Despite the prevalence of short tandem repeat expansion disorders, genetically diagnosing these conditions is complicated by a lack of efficient …
Read PDFBACKGROUND: Qinchuan cattle, renowned for their distinctive meat quality, flavor, and exceptional environmental adaptability, represent a highly valuable genetic resource in beef cattle breeding. However, the molecular mechanisms underlying the formation of its meat quality …
Read PDF<h4>Background</h4>A polygenic risk score (PRS) enables personalisation of cancer risk and supporting risk stratification for melanoma, colorectal, breast, and prostate cancers. Including a PRS in a cancer risk assessment can facilitate risk-appropriate cancer screening by …
Read PDF<h4>Background</h4>Genomic approaches can provide critical insights into the genetic health of endangered species and the impacts of long-term management on semi-captive populations. Asian elephants (Elephas maximus), listed as Endangered, include a large semi-captive population in …
Read PDFThe AFROSCREEN initiative, implemented in 13 countries, has strengthened regional genomic surveillance through investments in sequencing infrastructure, workforce training, and cross-country coordination, evolving from a SARS-CoV-2-focused effort into a multi pathogen platform. By building local …
Read PDF<h4>Objective</h4>The objective of this study is to employ Mendelian randomization (MR) to screen for gut microbiota (GM) exhibiting causal genetic effects on primary liver cancer (PLC) development and to predict promising traditional Chinese medicine (TCM) …
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