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The coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has led to significant global health burden, including both acute infections and persistent post-acute sequelae, also known as Long COVID …
Read PDF<h4>Introduction</h4>Common forms of dementia include Alzheimer's disease (AD), dementia with Lewy bodies (DLB), and frontotemporal dementia (FTD). Disease specific biomarkers are needed for differential disease diagnosis.<h4>Methods</h4>We performed cerebrospinal fluid (CSF) mass spectrometry proteomics on three …
Read PDFArtificial intelligence (AI) techniques have transformed proteomics and computational biology over the past decade, particularly in mass spectrometry tasks such as fragment spectra prediction, retention time prediction, and peptide detectability prediction. However, as the volume …
Read PDFPost-translational modifications (PTMs) on proteins play crucial roles in various biological processes. Two highly dynamic modifications, phosphorylation and O-linked N-acetylglucosamine modification (O-GlcNAcylation), are essential for cellular physiology and pathology. Emerging evidence suggests intimate crosstalk between …
Read PDFAmyloidosis is a heterogeneous group of protein misfolding disorders characterized by the deposition of amyloid fibrils in tissues, which causes progressive organ dysfunction. Among the various forms, cardiac involvement by transthyretin (ATTR) and immunoglobulin light …
Read PDF<h4>Background</h4>Retinal neurodegeneration is an early and independent feature of diabetic retinal disease and has been proposed as a window into the systemic neural consequences of diabetes, yet accessible molecular biomarkers and individualized prediction tools remain …
Read PDFBACKGROUND: Coagulation dysfunction is a common complication of hepatocellular carcinoma (HCC) and is reflected clinically by the international normalized ratio (INR), yet its serum molecular correlates remain poorly defined. We aimed to identify an INR-associated …
Read PDFRecent advancements in neuroproteomics have enabled detailed analysis of protein expression in the human brain, yet resolving synaptic dysfunction-a central feature of many neurological and psychiatric disorders-requires careful methodological consideration. Leveraging the high sensitivity of …
Read PDF<h4>Purpose</h4>To explore whether the proteome of aqueous collected during primary repair of rhegmatogenous retinal detachment (RD), differs between patients who experience recurrency (Recurrent RD Group) and those who do not (No Recurrent RD Group).<h4>Methods</h4>The aqueous …
Read PDFThis study aimed to investigate the pathogenic mechanisms of jaw cysts by screening for differentially expressed proteins in the tissues of patients with jaw cysts using proteomic techniques. Tissue samples were collected from 4 patients …
Read PDF<i>Listeria monocytogenes</i> is an important food-borne pathogen that is responsible for contamination of a variety of food products. It causes listeriosis which is one of the most severe and serious foodborne diseases, whose main severe …
Read PDFProtein N-glycosylation plays critical roles in controlling cell function, yet its specific contributions to pulmonary arterial hypertension (PAH) remain poorly understood. Here, we performed an integrated proteomic and site-specific N-glycoproteomic analysis of lung tissues from …
Read PDFChymotrypsin is widely used in shotgun proteomics, owing to its orthogonal cleavage specificity relative to trypsin, which enhances sequence coverage of hydrophobic protein regions. However, commercial preparations often display variable cleavage specificity, trypsin contamination, and …
Read PDF<h4>Purpose of review</h4>This review critically evaluates proteomics research applied to clinical nutrition and metabolism published between mid-2024 and early-2026, examining whether recent advances have moved the field closer to clinically actionable precision nutrition applications.<h4>Recent findings</h4>Large …
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