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An approach for the systematic profiling of drug-induced remodeling of RNA-RBP (RNA-binding protein) interactions
Nucleic acid-based therapeutics targeting RNA-related regulatory networks have received substantial attention in drug development, among which the interventions of RNA-RBP (RNA-binding protein) interactions or RNA-protein complex assemblies represent a promising strategy for treating various diseases. …
Read PDFEmerging Function of Prolactin-Inducible Protein-Is This Important Tear Protein Found in Alzheimer's Disease?
Alzheimer's disease is characterized by a chronic, long-term neurodegenerative process and an increasing need for easily accessible biomarkers that enable early diagnosis and disease monitoring. For this reason, tears have attracted growing interest as a …
Read PDFResearch progress on biomarkers of immunoglobulin a vasculitis nephritis: from classical molecules to multi-omics system analysis
Immunoglobulin A vasculitis nephritis (IgAVN) is the most common secondary glomerular disease in children, and the severity of renal involvement is a critical determinant of long-term prognosis. Although renal biopsy remains the gold standard for …
Read PDFTime-Resolved Proteomic Analysis in Zebrafish Using Bioorthogonal Noncanonical Amino Acid Tagging
Tracking time-dependent proteomic changes remains challenging. Bioorthogonal noncanonical amino acid tagging (BONCAT) offers a targeted approach for identifying proteins synthesized within defined time windows. Here, we describe BONCAT proteomic analysis in larval zebrafish, a model …
Read PDFA cysteine reactive chloroalkane probe enables HaloTag ligation for downstream chemical proteomics analysis
Chemical proteomics is a powerful method to track proteins labelled by reactive small molecules in living cells on a proteome-wide scale. The strategy relies on the reactivity and specificity of bioorthogonal 'click reactions'. Although a …
Read PDFEnhanced Prediction of Peripheral Artery Disease Using Plasma Proteomics Among Individuals Without Diabetes
<h4>Background</h4>Although peripheral artery disease (PAD) is an important diabetes complication, a substantial proportion of cases occur among individuals without diabetes. This study aimed to assess the predictive value of plasma proteomics in the long-term risk …
Read PDFBenchmarking Plasma Proteomics Workflows and Their Correlation to Clinical Routine Protein Assays
Plasma proteomics based on mass spectrometry has great potential for biomarker discovery. Plasma is challenging for mass spectrometry due to the high dynamic range in protein abundance. Several workflows have been developed to overcome this, …
Read PDFDecoding the Functional Proteome of <i>Vitis</i>: Past, Present, and Future
Proteomic research in the genus <i>Vitis</i> has progressed from early biochemical studies of soluble proteins to high-resolution, quantitative analyses encompassing all major organs and derived products. This review provides a comprehensive synthesis of advances in …
Read PDFAutomatic Blood Protein Enrichment by Magnetic-COF Polymers
Blood proteome is a highly informative biological fluid, reflecting physiological and pathological states across the entire body. It contains thousands of proteins spanning a dynamic range of more than 10 orders of magnitude. This makes …
Read PDFIdentification of a plasma proteomic signature associated with sudden cardiac death risk in the UK biobank
<h4>Background</h4>Sudden cardiac death (SCD) remains difficult to predict in the general population, and proteomics may offer additional prognostic information. We aimed to develop and evaluate a plasma proteomic signature for SCD risk prediction in the …
Read PDFLongitudinal Multi-Omics Profiling of Aqueous Humor Implicates GALNS Depletion as a Pro-Fibrotic Mediator of Anti-VEGF Therapy in PDR
<h4>Purpose</h4>Preoperative anti-vascular endothelial growth factor (VEGF) therapy in proliferative diabetic retinopathy (PDR) may exacerbate fibrovascular contraction, posing significant challenges. This study aims to characterize proteo-metabolomic changes induced by anti-VEGF therapy, validate key candidates on orthogonal …
Read PDFProteomic signatures of renal recovery from acute kidney injury-a translational study in critically ill postoperative patients
<h4>Background</h4>Acute kidney injury (AKI) is a common complication in critically ill patients and frequently progresses to persistent renal dysfunction. However, mechanisms underlying renal recovery versus persistent dysfunction remain poorly understood. Plasma proteomic profiling may identify …
Read PDFBlood proteomics: insights from public data
The circulating blood proteome comprises soluble and cellular components that reflect physiological and pathological states across tissues. Advances in mass spectrometry and affinity-based proteomics have improved sensitivity and throughput, enabling the generation of public blood …
Read PDFProteomics Analysis Reveals Serum Biomarkers Reflecting Joint Pain and Physical Limitations in Knee Osteoarthritis Before and After Joint Replacement Surgery
ObjectiveOsteoarthritis (OA) is an age-related musculoskeletal disorder lacking effective disease-modifying therapies and early diagnostic biomarkers. This study aimed to identify serum proteins that could indicate the occurrence of knee OA (KOA) and correlate with patients' …
Read PDFClinical validation of PEA-driven Olink proteomic discovery: INPP1 and ARHGAP25 serum biomarkers improve early breast cancer diagnosis
<h4>Background</h4>Breast cancer is the most common malignant tumor in women all over the world, accounting for 15% of all female cancer-related mortality. Due to the limited sensitivity of current serum biomarkers (such as CA15-3, CEA) …
Read PDFAn Integrative Proteomic Approach to Reveal Altered Signaling Modules During Alzheimer's Disease Progression in PS19 Tauopathy Mice
Alzheimer's disease (AD) is a slowly progressive neurodegenerative disease that is characterized by cognitive, functional, and behavioral impairments. These changes occur owing to the progressive accumulation of extracellular amyloid-beta plaques and intracellular neurofibrillary tangles of …
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