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Colorectal cancer (CRC) remains a leading cause of cancer-related mortality worldwide. Stage II CRC poses a clinical challenge due to its heterogeneous outcomes, with 15-20% of patients experiencing recurrence. Current prognostic models based on clinicopathologic …
Read PDFMLMarker is a machine learning tool that computes continuous tissue similarity scores for proteomics data, addressing the challenge of interpreting complex or sparse datasets. Trained on 34 healthy tissues, its Random Forest model generates probabilistic …
Read PDF[This corrects the article DOI: 10.1017/awf.2025.10055.].
Read PDFObesity is a major global health challenge characterized by chronic low-grade inflammation, oxidative stress, and an increased risk of cardiometabolic disorders. Although sex-related differences in inflammatory and redox biomarkers have been reported in obese populations, …
Read PDFPost-translational modifications (PTMs), such as Small Ubiquitin-like Modifier (SUMO)ylation and ubiquitination, regulate key cellular processes by covalently attaching to lysine residues. While mass spectrometry allows site-specific identification of PTMs, most existing search engines are optimized …
Read PDF<h4>Background</h4>Sepsis recognition in the ICU remains variable and relies on consensus clinical criteria rather than biomarker-defined rules. Routine laboratory and physiologic data often overlap with noninfectious critical illness, obscuring early identification. We evaluated whether discovery …
Read PDFWhile proteomics is being increasingly applied to investigate extracellular vesicles (EVs), there remains no consensus on how to address the inevitable missing values within proteomics datasets. Here, we devised a three-step approach that prioritized retaining …
Read PDF<h4>Background</h4>Prostate cancer (PCa), particularly in its advanced and castration-resistant forms, remains a major threat to men's health, with the tumor microenvironment (TME) playing a crucial role in its progression. Tumor-associated macrophages (TAMs), especially the M2 …
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Read PDF<i>MRPS22</i>-related mitochondrial disease (MIM#611719) is a rare autosomal recessive disorder caused by defects in the mitochondrial ribosomal protein S22, a component of the small mitoribosomal subunit essential for mitochondrial translation. Of the few reported cases, …
Read PDFPancreatic ductal adenocarcinoma (PDAC) evolves through precursors, yet the protein programs governing early progression remain poorly defined. We applied Deep Visual Proteomics (DVP)-integrating computational pathology, laser microdissection, and mass spectrometry (MS)-to profile normal ducts, acinar-to-ductal …
Read PDF<h4>Introduction</h4>Alzheimer's disease (AD) is a heterogeneous disease with diverse disease progression trajectories and brain pathology. Identifying AD subtypes is essential for understanding AD etiology, heterogeneity, and developing precise treatment.<h4>Methods</h4>We applied a subspace-merging algorithm to integrate …
Read PDFBACKGROUND: Irsenontrine (E2027) is a potent and selective PDE9 inhibitor that increases cellular cGMP, essential for glutamatergic synaptic function, and was investigated as symptomatic treatment for dementia with Lewy bodies (DLB). A recent Phase 2 …
Read PDFMissing data is often treated as a nuisance, routinely imputed or excluded from statistical analyses, especially in nominal datasets where its structure cannot be easily modeled. However, the form of missingness itself can reveal hidden …
Read PDFIn the absence of molecular biomarkers, the current diagnosis of multiple sclerosis is based on clinical assessment, neuroimaging, and detection of oligoclonal bands in cerebrospinal fluid. Early and rapid diagnosis using patient samples obtained by …
Read PDF<h4>Introduction</h4>Cerebral amyloidosis is a defining feature of Alzheimer's disease (AD), yet the molecular heterogeneity among amyloidbeta-positive (Aβ+) individuals remains poorly defined. We aimed to map the proteomic correlates of cerebral amyloidosis and link them to …
Read PDF<h4>Background</h4>The diagnosis of inflammatory bowel disease (IBD), ulcerative colitis (UC), and Crohn's disease (CD), relies on clinical and pathological criteria. Non-invasive precision medicine tools to diagnose IBD and discriminate between UC and CD are needed …
Read PDFAntimicrobial resistance (AMR) is an increasing challenge for the therapy of bacterial infections. Currently, patient treatment is guided by antimicrobial susceptibility testing (AST) using phenotypic assays and species identification by MALDI-ToF biotyping. Bacterial phenotype prediction …
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