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Pancreatic ductal adenocarcinoma (PDAC) has poor prognosis as early-stage asymptomaticity leads to late-stage diagnoses. Strategies to detect PDAC earlier or identify high-risk individuals are therefore paramount. Here, we report results from genetically engineered mice and …
Read PDFAntimicrobial resistance (AMR) has emerged as a critical global health challenge, supported in part by bacterial taxa that act as reservoirs of resistance determinants, facilitating their dissemination across microbial communities under antibiotic selective pressure. Among …
Read PDFMass spectrometry (MS)-based proteomics provides deep molecular insights from patient samples, but clinical use has been limited by missing values, static biomarker panels, and the need for targeted assay development. We present a framework - …
Read PDFOBJECTIVE: Intravenous glucocorticoids are the first-line therapy for moderate-to-severe active thyroid eye disease (TED), but some patients demonstrate steroid resistance. Therefore, identifying reliable pre-treatment biomarkers to predict the therapeutic response to intravenous glucocorticoids is of …
Read PDF<h4>Introduction</h4>Post-COVID condition (PCC) encompasses a spectrum of clinical symptoms affecting multiple organs that persist for >3 months after resolution of the initial SARS-CoV-2 infection. The complex nature of PCC symptoms makes it difficult to decipher …
Read PDFThe increased prevalence of inflammatory skin diseases such as atopic dermatitis, hidradenitis suppurativa, acne, lupus erythematosus in African American (AA) compared to White Non-Hispanic population is well recognized. However, the underlying mechanisms are largely unknown. …
Read PDFLaser capture microdissection (LCM) combined with liquid chromatography-tandem mass spectrometry (LC-MS/MS) enables spatial proteomics at the few-cell level but is constrained by cumulative losses during specimen capture, surface adsorption during processing, and sample transfer prior …
Read PDFThe proteomics community has fully embraced data sharing, yet data set metadata provision remains limited, especially at the level of the biological samples and experimental design. This hampers large-scale data reuse, as comprehensive and structured …
Read PDF<h4>Background</h4>Spatial proteogenomics marks a paradigm shift in oncology by integrating molecular analysis with spatial information from both spatial proteomics and other data modalities (e.g., spatial transcriptomics), thereby unveiling tumor heterogeneity and dynamic changes in the …
Read PDFIt is widely established that the layers of proteins bound to the surface of nanoparticles (NPs), also known as the protein corona, critically influence their behavior in biological environments. Despite numerous proteomics studies performed in …
Read PDFCorpus luteum (CL) is an endocrine structure that undergoes substantial changes over short intervals during the bovine reproductive (estrous) cycle. These changes are regulated by a vast array of signaling molecules, mainly proteins, that govern …
Read PDFPartial downregulation of pancreatic endoplasmic reticulum kinase (PERK) activity recovered insulin content in human islets exposed to glucolipotoxicity (GLT), resulting in improved insulin secretion and glucose-lowering effects in a mouse model of type 2 diabetes. …
Read PDFPeripheral artery disease (PAD) confers elevated risk for major adverse cardiovascular events (MACE), yet accurate risk stratification remains a challenge, particularly among patients with advanced disease necessitating endovascular revascularization. This study aimed to improve the …
Read PDF[This corrects the article DOI: 10.1016/j.toxcx.2026.100256.].
Read PDFCognitive dysfunction and neurodegenerative disorders represent an increasing clinical challenge in aging dogs and cats, while objective and minimally invasive biomarkers for early detection and disease monitoring remain limited. Tear film is a biologically active …
Read PDFFetal growth restriction (FGR) remains a major contributor to neonatal morbidity and mortality worldwide, with limited effective diagnostic and therapeutic options. To better understand its molecular mechanism, we performed integrated multi-omics analyses of placental tissues …
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Read PDFα-synuclein (α-syn) aggregation is a hallmark of synucleinopathies, a class of neurodegenerative disorders such as Parkinson's disease (PD). Several lines of evidence indicate the involvement of mitochondria in the disease pathology. Despite extensive study, the …
Read PDFTo investigate the mechanisms of biofilm (BF) formation in <i>Salmonella pullorum</i> (SP), a strong BF-forming strain designated 1904D10 was selected. Differential proteomics based on tandem mass tag (TMT) labeling was performed to compare the whole …
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