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MS-based proteomics offers powerful opportunities for biomarker discovery; nevertheless, it is associated with technical challenges, including missing values and batch effects. Although imputation and batch-correction methods are well established in proteomics, their impact remains incompletely …
Read PDF<h4>Introduction</h4>Reliable biomarkers for the diagnosis of chronic pancreatitis (CP) and pancreatic fibrosis severity are lacking, hindering effective treatment and management. Histologic fibrosis is a hallmark of late-stage CP, but noninvasive methods to evaluate fibrosis progression …
Read PDFBats are increasingly studied for their ability to coexist with diverse viruses of human health importance. While this focus has yielded insights into host–pathogen dynamics, baseline physiological data from healthy bats remain limited, constraining comparative …
Read PDFOats (<i>Avena sativa</i> L.) are a nutritionally valuable cereal crop known for their unique profile of bioactive compounds, including protein, β-glucan (BG), and avenanthramides (AVNs). However, industrial-scale processing and fractionation of these nutrients at an …
Read PDF<h4>Aims</h4>This study aimed to develop a non-invasive method combining urinary metabolomics and proteomics to identify biomarkers for gastric cancer and to elucidate the molecular mechanisms associated with its progression.<h4>Methods</h4>Urine samples from 30 advanced gastric cancer …
Read PDFNatural products keep earning their place in molecular science for a simple reason: they are chemically inventive, biologically "opinionated", and often arrive with a legacy of pre-existing relationship to human use that invites hypotheses instead …
Read PDFPublic proteomics repositories now host vast amounts of mass spectrometry data, yet much of it remains difficult to reuse, risking "data tombs" that are open access but not practically re-analyzable. In spring 2025, a graduate-level …
Read PDF<h4>Background</h4>The <i>C9ORF72</i> repeat expansion is the most common genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). While neurofilament light chain (NEFL) is an established biomarker of neuroaxonal damage, its specific dose-response relationship …
Read PDFIntervertebral disc degeneration (IDD) is a common condition associated with aging and degeneration of the disc. Type 2 diabetes mellitus (T2DM) is linked to various musculoskeletal disorders, including IDD, but its molecular effects on IDD …
Read PDFChronic kidney disease is a global public health concern, representing a critical global public health challenge with increasing morbidity and mortality rates. The disease is a long-term condition characterized by the progressive loss of renal …
Read PDFIt has long been a biological mystery why obesity increases cancer risk. Rapid advances in statistical and analytical methods are now opening the door to mechanistic discoveries that may finally resolve this question.
Read PDFChronic low-grade inflammation is a key feature of obesity-associated dysglycemia, yet substantial heterogeneity exists in inflammatory responses among individuals with normoglycemia, prediabetes, and type 2 diabetes mellitus (T2DM). Whether circulating inflammatory protein profiles define distinct …
Read PDFSleep need is associated with both circuit dynamics and widespread synaptic plasticity, yet the specific synaptic changes underlying sleep homeostasis remain incompletely understood. In <i>Drosophila</i>, sleep loss has been shown to trigger plasticity of the …
Read PDF<b>Background</b>: Venous thromboembolism (VTE) remains a leading cause of global morbidity and mortality. The pathophysiological mechanisms leading to VTE are still not fully elucidated. Diagnostic biomarkers for VTE lack specificity, and biomarkers to guide the …
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Read PDF<h4>Background</h4>Early diagnosis of pediatric sepsis is difficult because of the lack of specific clinical signs and limitations of standard biomarkers. Proteomics is a promising approach because it can identify disease-specific protein signatures.<h4>Aim</h4>To systematically evaluate the …
Read PDFBACKGROUND: Remission from pre-diabetes and type 2 diabetes (T2D) is frequently observed immediately after a duodenal/jejunal bypass. This demonstrates the reversibility of T2D and involvement of the proximal small intestine in T2D pathology. This study …
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