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Single amino acid variants (SAAVs) in protein sequences are often a direct result of single-nucleotide polymorphisms (SNPs). Certain germline SAAVs have shown biological relevance in different disease conditions but lack precise quantification in circulation, which …
Read PDF<h4>Purpose</h4>Coronavirus disease 2019 (COVID-19) has highlighted significant neurological complications in severe cases. Cerebrospinal fluid (CSF) proteomics could reveal biomarkers related to clinical outcome among critically ill patients.<h4>Experimental design</h4>We performed high-resolution proteomic analyses of CSF samples …
Read PDFSkin aging involves complex molecular changes that current strategies struggle to reverse. Here, we developed a machine learning approach using Support Vector Regression to predict biological skin age from proteomic profiles, enabling objective assessment of …
Read PDFNatural products, owing to their unique biological activities, possess the ability to interact with specific target proteins or regulatory networks, representing a valuable source of innovative drug candidates. However, target identification remains a major bottleneck …
Read PDF<h4>Background</h4>Infectious mononucleosis (IM), caused by Epstein-Barr virus (EBV) infection, is a prevalent disease among children and young adults and may lead to a range of severe complications. Proteomic analysis of extracellular vesicles (EVs) has shown …
Read PDFOrganophosphate esters (OPEs), widely used as flame retardants and plasticizers, are environmental toxicants known to disrupt lipid metabolism. Although most studies have focused on individual OPEs, environmental exposures typically involve complex mixtures. Our previous studies …
Read PDF[This corrects the article DOI: 10.1016/j.isci.2022.104093.].
Read PDF<h4>Introduction</h4>Psoriasis (PSO) is a chronic immune-mediated inflammatory skin disease characterized by keratinocyte hyperproliferation and dysregulated activation of the IL-23/IL-17 axis, leading to persistent cutaneous inflammation and substantial disease burden. Comprehensive profiling of circulating inflammatory proteins …
Read PDF<h4>Background</h4>Current therapeutic options for severe acute pancreatitis (SAP) remain limited. The integration of traditional Chinese and Western medicines offers a promising approach for patients with SAP, with Qingyi decoction (QYD) emerging as a classic and …
Read PDFCarbon fixation and metabolic efficiency in extremophiles offer promising avenues for sustainable bioproduction. <i>Priestia megaterium</i> SR7 is a supercritical CO<sub>2</sub>-tolerant extremophile, whose central carbon metabolism may be particularly well adapted toward efficient heterotrophic CO<sub>2</sub> fixation. …
Read PDF<h4>Background</h4>'Cutaneous T-cell lymphoma (CTCL), particularly tumor stage mycosis fungoides (MF), presents significant therapeutic challenges due to limited treatment efficacy. This study addresses the unmet need for novel targeted therapies targeting the constitutively hyperactive STAT3/5 pathway.<h4>Methods</h4>Kinome-wide …
Read PDFWheldone, a fungal metabolite, was identified as a cytotoxic compound in high-grade serous ovarian cancer (HGSOC). Wheldone induced caspase 3/7-dependent apoptosis and reduced migration, invasion, and spheroid growth. Wheldone stimulated apoptosis in chemoresistant HGSOC models. …
Read PDFIntrinsically disordered proteins and proteins containing intrinsically disordered regions often harbor sequences that are difficult to digest with conventional proteases, such as trypsin, Asp-N, or pepsin. In particular, proline-rich regions (PRRs) resist efficient proteolysis and …
Read PDFUsing human plasma and its protein-rich extracellular vesicles (EVs) for proteomic biomarker discovery requires an in-depth understanding of the influences of pre-analytical procedures. This study systematically investigates the ramifications of high-speed centrifugation, freeze-thaw cycles, and …
Read PDFPrimary TB and post-primary TB (PPTB) are different disease entities. PPTB occurs only in humans, and no animal model mimics the actual pathology of PPTB. Information on the immune pathogenesis of PPTB is lacking due …
Read PDFCo-pathology is a common feature of neurodegenerative diseases that complicates diagnosis, treatment and clinical management. However, sensitive, specific and scalable biomarkers for in vivo pathological diagnosis are not available for most neurodegenerative neuropathologies. Here we …
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