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Domoic acid (DA) is a well-known seafood toxin produced by some species of marine phytoplankton in the genus <i>Pseudo-nitzschia</i> during harmful algal blooms (HABs). Acute toxic exposures induce overt clinical signs of neuroexcitotoxicity, such as …
Read PDFMitochondrial disorders show remarkable clinical and genetic heterogeneity and result from variants in either mitochondrion- or nucleus-encoded genes. CHCHD4 is a component of the mitochondrial import and assembly pathway that imports small cysteine-containing substrates. We …
Read PDF<h4>Background/aim</h4>Although aldehyde dehydrogenases 1 family member A1 (ALDH1A1) has been extensively studied in cancer, its role in hepatocellular carcinoma (HCC) remains poorly understood. This study was designed to characterize the expression pattern and functional roles …
Read PDFThis review article presents a broad overview of developments and applications of capillary electrophoresis (CE) and microchip electrophoresis (MCE) in peptidomics and proteomics in the period 2023-2025. It deals with various methodological aspects, such as …
Read PDF<h4>Background</h4>Radiotherapy induces systemic changes beyond the targeted tumour site, yet the biological mechanisms driving these effects remain poorly understood. This study aims to longitudinally profile acute systemic plasma proteomic responses to radiotherapy in patients with …
Read PDFPhospholamban (PLN) p.Arg14del (R14<sup>Δ/+</sup>, also known as R14del) is a pathogenic variant that causes inherited cardiomyopathy. RNA therapy improves cardiac function and survival in murine PLN R14<sup>Δ/+</sup>. However, the molecular disease mechanisms and potential therapeutic …
Read PDFAdipose tissue-derived extracellular vesicles (adiposomes) carry a protein cargo that we previously showed differs between obese and lean individuals. In this study, we investigate how adiposomal protein cargo changes in response to sleeve gastrectomy and …
Read PDFMicrotubules attach to kinetochores to facilitate chromosome movement to opposite spindle poles. Defective kinetochore-microtubule attachments lead to phosphoryation of the outer kinetochore protein KNL1 at conserved MELT motifs, which triggers spindle assembly checkpoint activation and …
Read PDFFormic acid has long been the default acidic additive in reversed-phase LC-MS-based bottom-up proteomics, offering a practical balance between chromatographic performance and electrospray ionization (ESI) efficiency. Here, we evaluate propionic acid as an alternative mobile …
Read PDF<h4>Introduction</h4>Amyloidosis typing is crucial to determine the best therapeutic strategy for patients. Since conventional histological techniques often fail, the identification of amyloid precursors by mass spectrometry has become the new standard. However, without quantification, selecting …
Read PDFThe kinetoplast incorporates the large mitochondrial genome present in the eponymous Kinetoplastida. Trypanosoma brucei is an African trypanosome that can lose kinetoplast DNA (kDNA), however, when the nuclear-encoded gamma subunit of the mitochondrial F1FO-ATP synthase …
Read PDFMultiomic biomarker discovery generally uses well curated cohorts of patients and health individuals, although this can present challenges in validation and deployment of biomarkers for diagnosis in “real world” situations. An alternative approach is to …
Read PDFGlaucoma trabecular meshwork (GTM) cells cultured in vitro retain many characteristics of their in situ phenotype. Here, we used isobaric tandem mass tags (TMTpro) to label peptides from glaucomatous and non-glaucomatous TM (NTM) cells to …
Read PDFThis study conducted a comprehensive comparison of the metabolomic and proteomic profiles of pigeon breast muscles from 12-month-old (M12) and 28-day-old (D28) birds to investigate the influence of age on meat quality. The M12 samples …
Read PDFIn recent years, studies investigating protein-protein interactions on a proteome-wide scale have increased exponentially. These developments were achieved through implementation of new techniques, as well as improvements in mass spectrometry hardware. However, issues specific to …
Read PDF18β-Glycyrrhetinic acid (18β-GRA), a major bioactive component of licorice, exhibits recognized biological activities in various tumor models. However, its cellular effects and underlying molecular mechanisms in tongue squamous cell carcinoma (TSCC) are not well characterized. …
Read PDFThe ubiquitin-specific protease (USP) USP9X is a human deubiquitinase (DUB) with a large number of described targets and cellular roles. In cancer, USP9X is found as an oncogene or as a tumour suppressor depending on …
Read PDF4-Oxo-2-nonenal (ONE) is a highly reactive aldehyde derived from endogenous lipid peroxidation, which is associated with the development and progression of chronic human diseases. Despite the fact that ONE exerts biological effects mainly by modifying …
Read PDF<h4>Availability and implementation</h4>PG image and source code are available in github and dockerhub under LGPL-2.1.
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