Search the literature by keyword, topic, or author. Filter to articles with full text available.
3689 results
Understanding region-specific proteoform profiles in the brain is crucial for deciphering neural function and identifying therapeutic targets. Zebrafish (Danio rerio) is a valuable vertebrate model for neuroscience research due to its substantial conservation of brain …
Read PDFThe accuracy of crucial nuclear processes such as transcription, replication, and repair depends on the local composition of chromatin and the regulatory proteins that reside there. Understanding these DNA-protein interactions at the level of specific …
Read PDFThe oleaginous yeast Yarrowia lipolytica has been gaining increasing importance as an industrial biotech platform, supported by several available metabolic engineering tools. Genome-scale models (GEMs) are relevant to the iterative improvement of this yeast, and …
Read PDFA key goal of surfaceomic discovery technologies is to comprehensively interrogate the cell surface proteome to identify targets for immunotherapy development. Considerable progress has made in the application of surfaceomics to profile cancer cells. However, …
Read PDFBACKGROUND: Intrauterine adhesions (IUA) result from endometrial basal layer injury, leading to fibrous tissue formation and impaired fertility. Current treatments fail to fully reverse the fibrotic microenvironment. This study aimed to elucidate molecular mechanisms underlying …
Read PDFMultiple sclerosis (MS) is a chronic CNS disease characterized by demyelinated lesions. Gray matter lesions (GMLs) are associated with neurodegeneration and clinical disability, and normal appearing gray matter (NAGM) also shows neuropathology. The extracellular matrix …
Read PDFIn label-free mass spectrometry experiments, the data output is typically a proteome table that requires further processing, quality testing, and visualization to fully interpret the captured proteomic signals. Currently, post-quantification analysis of these tables often …
Read PDFMass spectrometry proteomics creates complex data representing the peptide/protein contents of biological samples. Various types of machine learning have been central to computational methods used to identify peptides from tandem mass spectra and numerous other …
Read PDFGiven the role of glutamate signaling in glioma-associated epilepsy (GAE) and glioma cell growth, amino acid transporters have gained attention as therapeutic targets. Here, we conducted a comparative analysis of four key transporters-xCT, CD98, EAAT2, …
Read PDFBACKGROUND: Type 2 diabetes complications manifest across various organs, but are fundamentally rooted in vascular dysfunction. This study aims to identify plasma protein signatures that improve prediction of macrovascular and microvascular complications in type 2 …
Read PDFBiomedical research has been transformed by the discovery of human induced pluripotent stem cells (iPSCs), providing unlimited access to patient-specific human cell types for disease modeling and mechanistic studies [...].
Read PDF<h4>Purpose</h4>Ventilator-associated pneumonia (VAP) is a common and serious complication in mechanically ventilated patients, with <i>Pseudomonas aeruginosa</i> (PA) being one of the most frequently encountered pathogens. Dysregulated protein expression is closely associated with the progression of …
Read PDFThe growing threat of antimicrobial resistance necessitates alternative strategies to conventional antibiotics. Insects represent a promising source of antimicrobial peptides (AMPs) due to their potent innate immune responses. In this study, we investigated the hemolymph …
Read PDF<h4>Background</h4>The exact pathogenesis of gouty arthritis (GA) is unclear. However, it is believed that GA is characterized by recurrent episodes and a self-limiting nature. During episodes, the disease primarily manifests locally, making local omics research …
Read PDF<h4>Introduction</h4>Understanding the molecular architecture of peripheral sensory neurons is critical as we pursue novel drug targets against pain and neuropathy. Sensory neurons in the dorsal root ganglion (DRG) show extensive compartmentalization; thus, understanding each compartment-from …
Read PDFThe APOE locus is the strongest genetic factor for Alzheimer's disease, with ε4 increasing and ε2 decreasing risk, yet the basis of these opposing effects remains unclear. Here we performed a multicohort proteomic analysis across …
Read PDF<h4>Aims</h4>Pulmonary veins in the left atrium (LA) are well-established as a critical site for the initiation of atrial fibrillation (AF). Emerging evidence suggests that in persistent AF (persAF), AF triggers may extend beyond LA. However, …
Read PDFAbsence epilepsy (AE) is a common pediatric epilepsy syndrome marked by brief lapses in consciousness and characteristic 2.5-4 Hz spike-and-wave discharges on EEG. Although its clinical and electrophysiological features are well established, the molecular mechanisms …
Read PDF<h4>Objective</h4>This study aimed to identify and validate noninvasive serum protein and metabolite biomarkers for the early detection and prognostic assessment of hepatocellular carcinoma (HCC).<h4>Methods</h4>In this study, we systematically analyzed serum proteomics and metabolomics across four …
Read PDF