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<i>Aquilaria sinensis</i> leaves are rich in bioactive compounds and have attracted increasing attention for their potential use in functional foods and health products. However, the effects of different processing methods on their metabolite profiles, regulatory …
Read PDF<h4>Background</h4>The incidence and prevalence of knee osteoarthritis (KOA) are on the rise, with the intricate etiology and pathogenesis of the disease posing significant challenges to global health. Although acupuncture has significant promise in modulating the …
Read PDF<h4>Background</h4>The significant clinical and molecular heterogeneity of pulmonary arterial hypertension (PAH) poses challenges in identifying effective therapies. Advanced multidimensional profiling offers an opportunity to capture molecular responses and assess biomarker stability, yet its application in …
Read PDFDevelopment of efficient bioconversion processes is limited by the ability to predictably improve metabolic flux. Here we deployed Bayesian Metabolic Control Analysis as a platform to integrate multi-omics data with metabolic modeling and evaluated its …
Read PDF<h4>Purpose</h4>It is well recognized that the proteomic plays a critical role in hepatocellular carcinoma (HCC) progression. However, the mechanisms of these proteins, particularly those regulated by phosphorylation, remain incompletely understood. This study aims to systematically …
Read PDFMicrobial coexistence in complex communities requires mechanisms that minimize competition and optimize resource use. However, the mechanisms by which these ecological strategies are executed remain poorly understood. Here we show that bacteria modulate protein abundance …
Read PDFThe gut bacterial microbiota is increasingly recognized as a key modulator of colorectal cancer (CRC) initiation, progression and response to therapy. However, the mechanisms by which bacteria influence the response to anticancer drugs remain poorly …
Read PDF<h4>Background</h4>Prefrailty is associated with anomalies in protein metabolism; however, the serum proteomic signatures remain unclear. This study investigated protein profiles across different health statuses and evaluated their potential for the early identification of prefrailty.<h4>Methods</h4>Older adults …
Read PDF<h4>Background</h4>Androgenetic alopecia (AGA) is characterized by androgen-dependent follicular miniaturization and progressive disturbance of follicular structure and cycling. Local steroid metabolism, including 5α-reductase-related androgen production and aromatase-related estrogen conversion, may contribute to this process.<h4>Methods</h4>A dihydrotestosterone (DHT)-induced …
Read PDFIn humans, testicular peritubular cells (TPCs) form a small compartment surrounding the seminiferous tubules and, as shown previously, undergo age-related changes. How they may contribute to the age-associated decline of testicular functions is not well …
Read PDF<b>Background</b>: Lipoprotein(a) [Lp(a)] is a genetically determined risk factor for atherosclerotic cardiovascular disease (ASCVD). Proteomic studies suggest that Lp(a)-associated proteins mediate inflammation, thrombosis, and vascular calcification, but methodological variability may influence proteome definition. <b>Methods</b>: Lp(a) …
Read PDF<h4>Background</h4>Multimorbidity, defined here as the co-occurrence of cardiovascular disease (CVD), type 2 diabetes (T2D), and/or cancer is a major public health challenge. However, its underlying biological mechanisms remain unclear, limiting progress toward identifying shared interventional …
Read PDF<h4>Background</h4>Normothermic machine perfusion (NMP) enables metabolic restoration and viability testing of liver grafts, but current viability criteria incompletely predict post-transplant outcomes. The molecular basis of graft resilience or biliary vulnerability remains unclear. This study aimed …
Read PDF<h4>Purpose</h4>Endometriosis is a prevalent inflammatory condition characterised by the presence of endometrial-like tissue outside the uterus and is associated with significant challenges, including diagnostic delays and continued reliance on laparoscopy. Although extensive research has investigated …
Read PDFKidney transplantation (KTx) is the preferred treatment for kidney failure. However, post-transplant management is challenging due to the limited lifespan of transplanted organs. Current methods for monitoring post-transplant complications are invasive and have limitations. Therefore, …
Read PDFThe architecture of bone defects presents a challenge in designing scaffolds that support structural integrity and enhance osteoinduction. To address this, a noninvasive injectable silk fibroin (SF)-based hydrogel incorporating magnetic nanohydroxyapatite (MHAp) and osteogenic growth …
Read PDF<h4>Introduction and aims</h4>Complications of type 2 diabetes are a primary cause of public health challenges in the field of diabetes. The emergence of metabolomics and proteomics provides a direct perspective for revealing the mechanisms of …
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Read PDFRapid and comprehensive analysis of complex proteomes across large sample sets is vital for unlocking the potential of systems biology. We present a high-throughput mass spectrometry (MS) proteomics method that integrates narrow-window data-independent acquisition (nDIA) …
Read PDFAnisakid nematodes are common foodborne parasitic nematodes with an important implication for seafood safety and public health. On top of usual symptoms resulting from infestation with live larvae, these nematodes have allergenic proteins that may …
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